Chemical composition of biliary calculi from Kanpur region     

S. K. Bansal  A. K. Gupta  A. Bansal  V. S. Rajput  L. D. Joshi 《Indian journal of clinical biochemistry : IJCB》1992,7(1):27-29

Gallstones from 24 female patients were subjected to quantitative chemical analysis. Two main categories of stones were identified: (1) Ten cholesterol stones with 93.38% cholesterol and only 0.17% bilirubin. (2) Mixed stones with cholesterol below 65%. They were sub-divided in two groups: (a) Six stones having 0.5% bilirubin and (b) Eight stones having 0.5% bilirubin. The calcium of cholesterol and mixed stones was comparable while phosphorus contents in cholesterol stones were low by over 30% in mixed stones.  相似文献   

Modelling the evolution of rates of ageing     

Vishal Gohil  Amitabh Joshi 《Resonance》1998,3(8):67-72

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The Shifting Balance Theory of Evolution     

Amitabh Joshi 《Resonance》1999,4(12):66-75

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Ernst Heinrich Philipp August Haeckel     

Amitabh Joshi 《Resonance》2018,23(11):1165-1176

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EGFR Mutation Analysis in Non-small Cell Lung Carcinoma Patients: A Liquid Biopsy Approach     

Jigna Joshi  Apexa Raval  Urja Desai  Vinal Upadhyay  Mansi Bhavsar  Kanisha Shah  Rakesh Rawal  Harsha Panchal  Franky Shah 《Indian journal of clinical biochemistry : IJCB》2021,36(1):51

In the era of the targeted therapy identification of EGFR mutation detection in lung cancer is extremely helpful to predict the treatment efficacy of EGFR tyrosine kinase inhibitors (TKIs). Unfortunately, the inadequacy and quality of the biopsy samples are the major obstacles in molecular testing of EGFR mutation in lung cancer. To address this issue, the present study intended to use liquid biopsy as the non-invasive method for EGFR mutation detection. A total of 31 patients with an advanced stage of lung cancer were enrolled in the study from which cell-free DNA (cfDNA) and FFPE tissue DNA was extracted. Extracted DNA samples were analyzed for further EGFR exon specific mutation analysis by ARMS-PCR. Data were analyzed statistically using SPSS software. In cfDNA samples, the prevalence of wild type EGFR was 48% while the prevalence of TKI resistant and TKI sensitive mutations were 3%. Conversely, in tissue DNA samples, the prevalence of wild type, TKI sensitive and TKI resistant mutations were 48%, 19%, and 3%, respectively. The overall concordance of EGFR mutation between cfDNA and tissue DNA was 83%. McNemar’s test revealed that there was no significant difference between EGFR expression of cfDNA and tissue DNA samples. Additionally, the significant-high incidence of TKI resistant mutations was observed in tobacco habituates, indicating the role of carcinogens present in the tobacco in developing resistant mutations. In conclusion, our data suggest that evaluation of EGFR mutation from cfDNA samples is practicable as a non-invasive tool in patients with advanced-stage of lung cancer.  相似文献   

Automated scoring in context: Rapid assessment for placed students     

Andrew Klobucar  Norbert Elliot  Perry Deess  Oleksandr Rudniy  Kamal Joshi 《Assessing Writing》2013,18(1):62-84

This study investigated the use of automated essay scoring (AES) to identify at-risk students enrolled in a first-year university writing course. An application of AES, the Criterion^® Online Writing Evaluation Service was evaluated through a methodology focusing on construct modelling, response processes, disaggregation, extrapolation, generalization, and consequence. Based on the results of our two-year study with students (N = 1,482) at a public technological research university in the United States, we found that Criterion offered a defined writing construct congruent with established models, achieved acceptance among students and instructors, showed no statistically significant differences between ethnicity groups of sufficient sample size, correlated at acceptable levels with other writing measures, performed in a stable fashion, and enabled instructors to identify at-risk students to increase their course success.  相似文献   

Role of Computers in Educating Young Children: U.S. and Japanese Teachers’ Perspectives     

Arti Joshi  Alex Pan  Masaru Murakami  Shankar Narayanan 《学校用计算机》2013,30(1):5-19

This study was conducted with kindergarten teachers in the United States and Japan with respect to their beliefs about the role of computers in educating young children. Overall findings indicated significant differences in responses of teachers in the two countries. Generally, U.S. teachers had a more positive attitude toward computers in educating young children, while the Japanese teachers had more concerns. The teachers’ own sense of competence with computers was not related to their beliefs about computers and young children in either country. Respondents from both countries identified a lack of resources and clear guidelines for integrating computers in the classroom as challenges. These findings highlighted the need for training of early childhood teachers in integrating and using computers in the classroom.  相似文献   

Characterization of Human Serum Immunoglobulin G Modified with Singlet Oxygen     

Aniket Gupta  Aadil Wani  Anamika Joshi  Haseeb Ahsan  Rizwan Ahmad 《Indian journal of clinical biochemistry : IJCB》2014,29(1):63-68

Reactive oxygen species, as singlet oxygen (¹O₂), is continuously being generated by aerobic organisms, and react actively with biomolecules. At excessive amounts, ¹O₂ induces oxidative stress and shows carcinogenic and toxic effects due to oxidation of lipids, proteins and nucleic acids. In our study, immunoglobulin G (IgG) was modified by ¹O₂ generated by the ultraviolet (UV) irradiation of methylene blue. The modified IgG was characterized by UV spectroscopy, carbonyl content determination, thermal denaturation and electrophoretic study. Oxidation induced by modification of IgG by ¹O₂ also analyzed by scavenging studies. It was found that ultraviolet absorption spectra of modified IgG shows marked hyperchromicity. The carbonyl content was found to be high in modified IgG as compared to native IgG which confirms its oxidation. Thermal denaturation of modified protein sample shows decrease in Tm value by 3 °C and less intensity banding pattern on polyacrylamide gel electrophoresis. The quenching effect of sodium azide provides clue for modification of IgG by methylene blue, as it is known ¹O₂ scavenger. Hence, the IgG modified with ¹O₂ may be one of the etiological pathogenic factors for rheumatoid arthritis and diabetes.  相似文献   

Equality and Opportunity in Education: Evidence from the 1958 and 1970 birth cohort studies     

John Bynner  Heather Joshi 《牛津教育评论》2013,39(4):405-425

There is controversy about whether inequalities and educational outcomes are increasing or decreasing. Using longitudinal data collected in two birth cohort studies started in 1970 and 1958 respectively, the paper examines the evidence in relation to two outcomes, probability of leaving school at 16 and highest qualification achieved. Multi-variate analysis (logistic and OLS regression) was used to model the relationships of these educational outcomes to family social class, taking account of a wide range of early life variables, including living in an urban as opposed to rural location. It is concluded that the impact of social class on educational achievement has not changed across the 12 years covered by the two studies, a result that applies in both rural and urban areas of Britain.  相似文献   

Kishore Vaigyanik Protsahan Yojana (KVPY) 2006     

A W Joshi  V H Raybagkar  F I Surve 《Resonance》2006,11(5):88-89

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