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Naoki Mantani Hiroshi Oka Takashi Watanabe Kyohei Miyakawa Yoko Kimura 《Indian journal of clinical biochemistry : IJCB》2021,36(3):375
HLA association with drug-induced liver injury has recently been pointed out about multiple medicines. The aim of this study was to evaluate relationship between HLA gene and liver injury related to Baikal skullcap-containing Kampo medicines (BSCK). We previously examined HLA genes in 3 cases of BSCK-induced liver injury. Recently we could encounter 2 cases diagnosed as “definitely-related case” of BSCK-induced liver injury. HLA genes of the 2 cases were analyzed by Sequencing Based Typing method with Next Generation Sequencer at HLA Laboratory in Kyoto. HLA-DPA1*02:02:02 and DPB1*05:01:01 were observed in the 2 cases: concordance was not observed in HLA-A, B, C, DRB1, DRB4, DQA1, or DQB1. The previous 3 cases of BSCK-induced liver injury had the same allele type to the 2 cases only in HLA-DPA1. Putting all these together, HLA-DPA1*02:02:02 was observed in common among 5 cases of BSCK-induced liver injury. HLA-DPA1*02:02:02 is possibly associated with BSCK-induced liver injury. 相似文献
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Surface modification is a critical issue in various applications of polydimethylsiloxane (PDMS)-based microfluidic devices. Here, we describe a novel method through which PDMS-based microchannels were successfully modified with fragmented poly(l-lactic acid) (PLLA) nanosheets through a simple patchwork technique that exploited the high level of adhesiveness of PLLA nanosheets. Compared with other surface modification methods, our method required neither complicated chemical modifications nor the use of organic solvents that tend to cause PDMS swelling. The experimental results indicated that the modified PDMS exhibited excellent capacity for preventing the adhesion and activation of platelets. This simple yet efficient method can be used to fabricate the special PDMS microfluidic devices for biological, medical, and even hematological purposes. 相似文献
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Toshiaki Nakazaw Manabu Yaguchi Kiyotaka Uchimoto Masao Utiyam Eiichiro Sumit Sadao Kurohashi Hitoshi Isahar 何彦青 刘建辉 《情报工程》2017,3(3):040-046
本文详细介绍了ASPEC（亚洲科学论文摘录语料库）。作为首个大规模的科学论文领域内的平行语料库,ASPEC 是由日- 中机器翻译项目于 2006 年至2010 年间利用科技促进专用协作基金构建起来的。它包含约300 万条平行语句的日- 英科学论文摘要语料库（ASPEC-JE）和约68万条平行语句的中- 日科学论文摘录语料库（ASPEC-JC）。ASPEC 被用作机器翻译评测研讨会WAT（亚洲翻译研讨会）的官方数据集。 相似文献
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Previous research has sometimes claimed a female advantage on tasks of incidental memory. However, it is uncertain whether the sex difference was due to the incidental, or to the heavily verbal, nature of the tasks used, since women are known to have better verbal memory than men. The current study asked whether a female superiority would be found under less verbally-loaded conditions. No sex difference was found on two different pictorial tasks, both of which measured incidental memory for the content of complex scenes. In contrast, a female advantage was observed across both incidental and intentional conditions when easily labeled stimuli were used. This advantage was eliminated on the incidental condition when the effects of intentional verbal memory were controlled for. These findings strongly suggest that previous reports of a female advantage on incidental memory may have been due to the choice of verbalizable stimuli. 相似文献
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In this study, we developed allometric exponents for scaling Wingate anaerobic test (WAnT) power data that are effective in controlling for body mass (BM) and lean body mass (LBM) and established a normative WAnT data set for college-age women. One hundred women completed a standard WAnT Allometric exponents and percentile ranks for peak (PP) and mean power (MP) were established. Allometric exponents were applied to WAnT scores for an independent sample (n=31) to assess external validity. PP and MP were 477.0 W (SD = 80.0) and 372.6 W (SD = 61.5), respectively. Allometrice exponents for PP and MP scaled for BM were b = 0.92 and b = 0.76, respectively, and for LBM they were b = 0.93 and b = 0.91, respectively. In the independent sample, these exponents produced correlations between allometrically scaled PP and MP and BM of r = -.02 and r = .02, respectively. Correlations between allometrically scaled PP and MP and LBM were r = .004 and r = -.02, respectively. The allometric exponents were effective in partialing out the effect of BM for PP and MP and demonstrated acceptable levels of external validity when applied to an independent sample. The allometric exponents and normative values provide a useful tool for comparing WAnT scores in college-age women without the confounding effects of BM or LBM. 相似文献
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From the perspective of the strategy-based judgment, the present paper researched the process by which the reading of a Chinese character (kanji) is identified as On (reading borrowed from Chinese) or Kun (native Japanese reading). In these experiments, questionnaires containing a list of Chinese characters and their associated readings were printed, and subjects were asked to judge whether the reading given was On or Kun. Subjects were also asked to state the degree of confidence they felt in making this judgment. In Experiment 1, the survey consisted of characters which have only an On-reading. The correct rate and degree-of-confidence judgments from this test suggest that in deciding whether a reading is On or Kun, the strategy employed is If the reading for a character which occurs independently has concrete meaning, it is a Kun-reading; if the reading does not have concrete meaning, it is an On-reading. In Experiment 2, the questionnaire was made up of characters with multiple readings, both On and Kun. From the results of this latter experiment, it would appear that the strategy employed when a character has multiple readings is to reserve judgment regarding the On- or Kun-reading until after the various possible readings have been compared with one another. In addition, the results of these experiments suggest that the strategy employed differs depending on the number of readings that can be assigned to each character. When only one reading is possible, subjects make a judgment directly, but when multiple readings exist for a given character the subjects first compare the possible readings and make inferences; only when this process is complete do they apply a strategy to identify a reading as On or Kun. 相似文献
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David S. Crystal Chuansheng Chen rew J. Fuligni Harold W. Stevenson Chen-Chin Hsu Huei-Jen Ko Seiro Kitamura Susumu Kimura 《Child development》1994,65(3):738-753
American, 1,633 Chinese, and 1,247 Japanese eleventh-grade students, 5 indices of maladjustment included measures of stress, depressed mood, academic anxiety, aggression, and somatic complaints. Asian students reported higher levels of parental expectation and lower levels of parental satisfaction concerning academic achievement than their American peers. Nevertheless, Japanese students reported less stress, depressed mood, aggression, academic anxiety, and fewer somatic complaints than did American students. Chinese students reported less stress, academic anxiety, and aggressive feelings than their American counterparts, but did report higher frequencies of depressed mood and somatic complaints. High academic achievement as assessed by a test of mathematics was generally not associated with psychological maladjustment. The only exception was in the United States, where high achievers indicated more frequent feelings of stress than did low achievers. 相似文献
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Cell-secreted soluble factor signaling in a diffusion dominant microenvironment plays an important role on early stage differentiation of pluripotent stem cells invivo. In this study, we utilized a membrane-based two-chambered microbioreactor (MB) to differentiate mouse embryonic stem cells (mESCs) in a diffusion dominant microenvironment of the top chamber while providing enough nutrient through the bottom chamber. Speculating that accumulated FGF4 in the small top chamber will augment neuronal differentiation in the MB culture, we first differentiated mESCs for 8 days by using a chemically optimized culture medium for neuronal induction. However, comparison of cellular morphology and expression of neuronal markers in the MB with that in the 6-well plate (6WP) indicated relatively lower neuronal differentiation in the MB culture. Therefore, to investigate whether microenvironment in the MB facilitates non-neuronal differentiation, we differentiated mESCs for 8 days by using chemically defined basal medium. In this case, differentiated cell morphology differed markedly between the MB and 6WP cultures: epithelial sheet-like morphology in the MB, whereas rosette morphology in the 6WP. Expression of markers from the three germ layers indicated lower neuronal but higher meso- and endo-dermal differentiation of mESCs in the MB than the 6WP culture. Moreover, among various cell-secreted soluble factors, BMP4 expression was remarkably upregulated in the MB culture. Inhibition of BMP4 signaling demonstrated that enhanced effect of upregulated BMP4 was responsible for the prominent meso- and endo-dermal differentiation in the MB. However, in the 6WP, downregulated BMP4 had a minimal influence on the differentiation behavior. Our study demonstrated utilization of a microbioreactor to modulate the effect of cell-secreted soluble factors by autoregulation and thereby inducing alternative self-capability of mESCs. Understanding and implementation of autoregulation of soluble factors similar to this study will lead to the development of robust culture systems to control ESC behavior. 相似文献