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11.
Abdorrahim Absalan Javad Mohiti-Ardakani Hossein Hadinedoushan Mohammad Ali Khalili 《Indian journal of clinical biochemistry : IJCB》2012,27(4):351-356
Cinnamon has been used as an anti-diabetic agent for centuries but only in recent few years its mechanism of action has been under investigation. Previous studies showed that cinnamon might exert its anti-diabetic effect via increasing glucose transporter isotype-4 (GLUT4) gene and glycoprotein contents in fat cells. To study if hydro-alcoholic cinnamon extract (HACE) enhances GLUT4 translocation from intracellular compartments of nuclear or endoplasmic reticulum membranes (N/ER) into the cytoplasmic membrane (CM). C2C12 myoblastic cell line were seeded in DMEM plus 20 % FBS and differentiated to myotubes using 2 % horse serum. After myotubes formation, 100 or 1,000 μg/ml HACE, as intervention, and as control 1 % DMSO were added for 3 h. Cells were washed and homogenized followed by ultracentrifuge fractionation, protein separation by SDS-PAGE and GLUT4 detection using semi-quantitative Western blotting. Data analysis was done by two-independent samples t test for comparison of mean ± SD of GLUT4 percent in categories. GLUT4 contents were higher in CM of groups 100 and 1,000 μg/ml HACE and lower in 1 % DMSO treated myotubes (CI = 0.95, P < 0.05). For N/ER reverse results were obtained (CI = 0.95, P < 0.05). As our results have shown HACE induces GLUT4 translocation from intra-cell into cell surface. We conclude that cinnamon maybe a choice of type-2 diabetes mellitus treatment because its extract enhances GLUT4 contents in CM where it facilitates glucose entrance into the cell. However it is necessary to trace the signaling pathways which are activated by HACE in muscular tissue. 相似文献
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Hossein Parastvand Airlie Chapman Octavian Bass Stefan Lachowicz 《Journal of The Franklin Institute》2021,358(7):3919-3942
This study investigates on a strong correlation between complex network (CN) controllability (characterized by the number of required driver nodes) and graph symmetry (described by automorphism groups) in undirected and unweighted networks. Based on the properties of permutation products of elementary automorphisms, novel necessary conditions for CN controllability are presented which are computationally more effective than previous method. In addition, a novel index of symmetry is proposed upon which a more meaningful understanding of symmetry impact on CN controllability can be comprehended. Based on this new index, a modification strategy is suggested aiming to satisfy CN controllability with a lower number of driver nodes. The study shows that the proposed modification approach can result in a minimal set of driver nodes with a reasonable computational complexity. Further, the critical components of complex networks, in terms of their impact on the number of required driver nodes, are identified. The results of the proposed methodologies have been verified for several synthetic and real test systems including small, medium, and large power networks. 相似文献
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Hossein Nassaji Sandra Fotos 《通化师范学院学报》2006,(4):35-40
There are a number of studies that have investigated the effects of textual enhancement on drawing the learner＇s attention to grammar, and the method has been described as the least explicit and the least intrusive method of focus on form （Doughty ＆ Varela, 1998）. It involves highlighting certain features of input that might go unnoticed under normal circumstances by typographically manipulating them through boldfacing, italicizing, underlining, or capitalizing. The assumption is that such manipulations enhance the perceptual saliency of the target structures, and this, hence, increases their chance of being notieed. A related technique is the provision of numerous instances of target linguistic forms in the input, called an inputflood （Trahey ＆ While, 1993）. Again, the assumption is that frequent exposure to target items enhances their saliency and hence results in noticing the forms （ Schmidt, 1990; Sharwood Smith, 1993）. Whereas studies by Doughty （1991） and Fotos （1994） reported positive results in terms of awareness of target structures and proficiency gains resulting from textually enhanced structures, 相似文献
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Karami R Hosseini M Khodabandehloo F Khatami L Taiarani Z 《Journal of Zhejiang University. Science. B》2011,12(12):1016-1023
Objective
The roles of gonadal hormones and nitric oxide (NO) on the analgesic effects of morphine, tolerance to morphine, and their interactions have been widely investigated. In the present study, the effect of l-arginine (an NO precursor) on morphine tolerance in sham and ovariectomized (OVX) female mice was investigated. 相似文献15.
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Enthusiasm for information technology (IT) is growing among older adults. Many older adults enjoy IT and the Internet (Pro-Nets), but others have no desire to use it (No-Nets). This study found that Pro-Nets and No-Nets were different on a number of variables that might predict IT use. No-Nets were older, had less education and income, were retired, in poor health, and less active than Pro-Nets. No-Nets potentially have the most to gain from access to—and training inusing—the Internet as a health management tool. Further research with this population could inform the development of health-related web based interventions. 相似文献
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Whether screening tests or teacher ratings best predict children at risk for reading failure continues to be an area of disagreement in the early identification literature. Our early studies confirmed low positive identification rates (30%) when kindergarten teachers were asked to predict future reading achievement using a traditional rating scale, while a project-developed, theory-based screening battery correctly identified 81% of poor readers. Construction of a teacher rating scale of current skill levels on research-validated precursors to reading improved prediction in the current study, although results were still inferior to the screening test (64% and 80% valid positives, respectively). Combining test results and teacher ratings resulted in 88% identification of those who failed in first, second, or third grade, suggesting that both teacher ratings and screening tests should be used to identify the largest number of those who will later fail in reading. © 1998 John Wiley & Sons, Inc. 相似文献
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Shokrollah Hamdhaidari Hossein AgahiAbdulhamid Papzan 《International Journal of Educational Development》2008
This paper examines the development of higher education in Iran during a 26-year period under the Islamic government. This can be divided into three different phases: revolutionary, formative and development. It explores the expansion of universities, enhancing research, widening access, use of a wide range of ICT, decentralisation and gender equity. The quality and relevance of curricula with the market requirement is also discussed. This paper argues that the curriculum should be more specific and address the real needs of society. Comprehensive decision-making, expanding students’ academic guidance and expanding participatory and student-centre environment in higher education are crucial. 相似文献
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