Robust fluidic connections to freestanding microfluidic hydrogels     

Shannon L. Faley  Bradly B. Baer  Taylor S. H. Larsen  Leon M. Bellan 《Biomicrofluidics》2015,9(3)

Biomimetic scaffolds approaching physiological scale, whose size and large cellular load far exceed the limits of diffusion, require incorporation of a fluidic means to achieve adequate nutrient/metabolite exchange. This need has driven the extension of microfluidic technologies into the area of biomaterials. While construction of perfusable scaffolds is essentially a problem of microfluidic device fabrication, functional implementation of free-standing, thick-tissue constructs depends upon successful integration of external pumping mechanisms through optimized connective assemblies. However, a critical analysis to identify optimal materials/assembly components for hydrogel substrates has received little focus to date. This investigation addresses this issue directly by evaluating the efficacy of a range of adhesive and mechanical fluidic connection methods to gelatin hydrogel constructs based upon both mechanical property analysis and cell compatibility. Results identify a novel bioadhesive, comprised of two enzymatically modified gelatin compounds, for connecting tubing to hydrogel constructs that is both structurally robust and non-cytotoxic. Furthermore, outcomes from this study provide clear evidence that fluidic interconnect success varies with substrate composition (specifically hydrogel versus polydimethylsiloxane), highlighting not only the importance of selecting the appropriately tailored components for fluidic hydrogel systems but also that of encouraging ongoing, targeted exploration of this issue. The optimization of such interconnect systems will ultimately promote exciting scientific and therapeutic developments provided by microfluidic, cell-laden scaffolds.  相似文献   

Knowledge of bout duration influences pacing strategies during small-sided games     

John Andrew Sampson  Hugh Head Kelsham Fullagar  Tim Gabbett 《Journal of sports sciences》2015,33(1):85-98

This investigation examines pacing during intermittent team sports. Sixteen junior Rugby League players participated in eight different small-sided offside touch games. All games were 24 min, but bout durations differed in continuous (1 × 24 min) or repeated (2 × 12, 3 × 8, 4 × 6, 6 × 4, 8 × 3, 12 × 2 or 24 × 1 min) formats. Repeat bouts were interspersed by 2 min of passive rest, and participants were informed of the bout duration immediately prior to the game. Heart rates, ratings of perceived exertion and data gathered from global positioning system devices were used to investigate the pacing strategies employed within each game. No significant (P > 0.05) between-game differences were observed in total distance; however, during the 1-min bouts, high-speed movement was significantly (P < 0.05) increased, during the first and second quarters of the 24 × 1-min game compared to all other formats (effect size range: 0.75 ± 0.61–1.38 ± 0.47). Furthermore, the rate of decline in high-speed movement over-time was greatest during the 24 × 1-min game with large differences observed between the first and third quarters (effect size: 0.90 ± 0.58). Greater moderate-speed (effect size range: 0.62 ± 0.63–1.56 ± 0.40) and less low-speed (effect size range: 0.69 ± 0.62–1.54 ± 0.40) distances were also observed during the 1-min bouts, yet heart rates were higher during the continuous 1 × 24-min game. Pacing strategies during intermittent activities are influenced by the number and duration of exercise bouts. Practitioners should consider within-game bout durations when prescribing game-based activities to improve aerobic capacity.  相似文献   

The Effects of Parental Behavior on Infants' Neural Processing of Emotion Expressions          下载免费PDF全文

Samantha Taylor‐Colls  R. M. Pasco Fearon 《Child development》2015,86(3):877-888

Infants become sensitive to emotion expressions early in the 1st year and such sensitivity is likely crucial for social development and adaptation. Social interactions with primary caregivers may play a key role in the development of this complex ability. This study aimed to investigate how variations in parenting behavior affect infants' neural responses to emotional faces. Event‐related potentials (ERPs) to emotional faces were recorded from 40 healthy 7‐month‐old infants (24 males). Parental behavior was assessed and coded using the Emotional Availability Scales during free‐play interaction. Sensitive parenting was associated with increased amplitudes to positive facial expressions on the face‐sensitive ERP component, the negative central. Findings are discussed in relation to the interactive mechanisms influencing how infants neurally encode positive emotions.  相似文献   

Research on teaching practicum – a systematic review     

Tony Lawson  Melek Çakmak  Müge Gündüz  Hugh Busher 《欧洲师范教育杂志》2015,38(3):392-407

The aim of the present study is to conduct a systematic review research which focuses on research studies into the school practicum. In order to identify the main issues and also to provide a contemporary picture of practicum, 114 studies published on the topic are reviewed and analysed in terms of: (i) aims, (ii) main participants, (iii) methodology used and (iv) the main outcomes emerging. Many of the reviewed studies take pre-service teachers as their main participants. The review also shows that many practicum studies are relatively small-scale studies since they are mainly qualitative focused and findings derived from a relatively small sample. This suggests that more large-scale studies are needed in the field in order to provide greater insight into teaching practicum. Finally, this systematic review provides some food for thought in the area of practicum research and promotes further studies in this complex field.  相似文献   

Reviewing the Family Unit as a Stakeholder in Talent Development: Is It Undervalued?     

Robin David Taylor  Dave Collins 《Quest (Human Kinetics)》2015,67(3):330-343

As elite youth sport becomes more organized and professionalized, the role of the family is increasingly acknowledged as being significant in the development of young talent. High-profile examples across a range of professional sports, both positive and negative, have drawn attention toward this important stakeholder. Accordingly, this review first examines the key issues in relation to family involvement in talent development in relation to what is perceived as good and bad practice on behalf of the family. Next the key theoretical underpinning is considered, Family Systems Theory, and how it may be integrated within elite youth sport. Finally, the article concludes with a summary of where the current literature leaves us and where we can progress from here. Two possible inputs are suggested that could benefit the effectiveness of family involvement: a focus on the family holistically and a second on the role different family members can play.  相似文献   

The role of work-related learning in the identity transformation of Canadian workers with low literacy skills     

Maurice C. Taylor  David L. Trumpower  Edward R. Purse 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2015,61(6):815-833

Workplaces are settings where power, knowledge and self are brought together in a complex social environment which includes various forms of struggle related to identity, agency, socio-cultural norms, political structures and functional practices. The purpose of this article is to uncover how formal and informal work-related learning processes influence the identity transformation of workers with low literacy and essential skills. Drawing on two recent Canadian data bases which serve as cases in this study, the position taken by the authors is that the organisational context can both facilitate and impede worker subjectivity. Various conditions, approaches to learning and training pathways are examined as they contribute to social cognitive and transformative learning theories.  相似文献   

The Student Perception of Wellbeing Questionnaire: Preliminary Investigation into its Psychometric Properties     

Mark Taylor 《International Journal of Disability, Development & Education》2015,62(1):99-115

An estimated 20% of all adolescents will experience a depressive disorder by the age of 18, with schools being at the forefront of initiatives to promote resilience and well-being. This study reports on the development of the 24-item Student Perception of Wellbeing Questionnaire (SPWQ), created as a measure of well-being in three areas: exercise, explanatory style, and conflict resolution. The SPWQ was administered to 235 male school students from Years 6–8 and 251 female students from Years 7–9, and a principal components analysis with varimax rotation was performed on the data obtained. A three-factor solution was identified dealing with explanatory style, conflict resolution, and exercise, which explained 31% of the total variance. The scale was found to have strong internal consistency with a Cronbach alpha coefficient of α = 0.80 for the male students and α = 0.84 for the female students.  相似文献   

A new industry creation and originality: Insight from the funding sources of university patents     

Marco Guerzoni  T. Taylor Aldridge  David B. Audretsch  Sameeksha Desai 《Research Policy》2014

Scientific breakthroughs coming from universities can contribute to the emergence of new industries, such as in the case of biotechnology. Obviously, not all research conducted in universities leads to a radical change from existing technological trajectories. Patents and patent dynamics have long been recognized as critical in understanding the emergence of new technologies and industries. Specifically, patent citations provide insight into the originality of a discovery that has received patent protection. Yet while a large body of literature addresses the impact of patent originality on various firm performance measures, we address the question of what conditions drive patent originality in the process of knowledge creation within the university. Using data on patented cancer research, we examine how research context – as reflected by the funding source for each scientist – is associated with patent originality. We find that when university scientists are partly funded by their own university, they have a higher propensity to generate more original patents. By contrast, university scientists funded either by industry or other non-university organizations have a lower propensity to generate more original patents. The significance of our findings in the cancer research setting call for further research on this question in other research fields.  相似文献   

Intramural Athletics for Men in Negro Colleges     

William S. Taylor 《Research quarterly for exercise and sport》2013,84(2):60-67

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Indian adult education and the post‐colonial legacy     

Tom Steele  Richard Taylor 《International Journal of Lifelong Education》2013,32(6):457-464

Under the Raj education concentrated on reproducing a small Anglicized elite capable of administering the country. Adult education was minimal and confined to a few urban centres. After Independence Indian adult education was burdened with the project of modernization as India under Nehru and the nationalist movement desperately tried to industrialize the state according to western and soviet models. Despite the relative success of the first Five Year Plan's literacy programme, levels of funding dropped while bureaucracy and falsification of figures increased. Despite Gandhi, Indian education also suffered from elitist discourses inherited from the British Raj which assumed a ‘trickle‐down’ effect and resulted in the over‐balancing of the system towards higher education. Western experts (with the honourable exception of Frank Laubach) have tended to confirm the bias, but even Laubach's agenda raised suspicion. Only with the coming of the NAEP in 1978 was a serious attempt to redress the balance made. Subsequent radical educationists have once again taken up the banner of ‘Gandhi’ in the cause of educating the very poor and the project of modernization has given way to more needs‐based programmes.  相似文献