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Ikram Khan Anil Prabhakar Chloe Delepine Hayley Tsang Vincent Pham Mriganka Sur 《Biomicrofluidics》2021,15(2)
Organoids are biological systems grown in vitro and are observed to self-organize into 3D cellular tissues of specific organs. Brain organoids have emerged as valuable models for the study of human brain development in health and disease. Researchers are now in need of improved culturing and imaging tools to capture the in vitro dynamics of development processes in the brain. Here, we describe the design of a microfluidic chip and bioreactor, to enable in situ tracking and imaging of brain organoids on-chip. The low-cost 3D printed microfluidic bioreactor supports organoid growth and provides an optimal imaging chamber for live-organoid imaging, with drug delivery support. This fully isolated design of a live-cell imaging and culturing platform enables long-term live-imaging of the intact live brain organoids as it grows. We can thus analyze their self-organization in a controlled environment with high temporal and spatial resolution. 相似文献
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This longitudinal study modeled lexical development among children who spoke Vietnamese as a first language (L1) and English as a second language (L2). Participants (n = 33, initial mean age of 7.3 years) completed a total of eight tasks (four in each language) that measured vocabulary knowledge and lexical processing at four yearly time points. Multivariate hierarchical linear modeling was used to calculate L1 and L2 trajectories within the same model for each task. Main findings included (a) positive growth in each language, (b) greater gains in English resulting in shifts toward L2 dominance, and (c) different patterns for receptive and expressive domains. Timing of shifts to L2 dominance underscored L1 skills that are resilient and vulnerable to increases in L2 proficiency. 相似文献
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Much research in the area of pre-service teacher (PST) identity formation has focused on the mentoring relationship between PSTs and their supervising teachers. While this is important to identity formation, interaction with peers is another area that needs to be examined. Using Wenger’s matrix as a theoretical framework, this study aimed to explore how PSTs’ identities are formed during the process of paired placement during the professional experience. Two pairs of PSTs were followed during the four-week professional experience. Data were collected from interviews with the PSTs before, during and after the professional experience. It is clear from this case study that the identity formation of PSTs is enhanced during a paired placement on their first professional experience. This finding has implications for teacher educators who are seeking evidence of the effectiveness of paired placements on the identity formation of PSTs during professional experience. 相似文献
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The tension between exploitation of the best options and exploration of alternatives is a ubiquitous problem that all organisms
face. To examine this trade-off across species, pigeons and people were trained on an eight-armed bandit task in which the
options were rewarded on a variable interval (VI) schedule. At regular intervals, each option’s VI changed, thus encouraging
dynamic increases in exploration in response to these anticipated changes. Both species showed sensitivity to the payoffs
that was often well modeled by Luce’s (1963) decision rule. For pigeons, exploration of alternative options was driven by experienced changes in the payoff schedules,
not the beginning of a new session, even though each session signaled a new schedule. In contrast, people quickly learned
to explore in response to signaled changes in the payoffs. 相似文献
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Tran Ly Thi Wall Tony 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2019,65(4):557-578
International Review of Education - Evidence now calls into question the efficacy and appropriateness of pedagogical practices that force international students to adapt to Eurocentric expectations... 相似文献
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The first exhibition in Vietnam to feature Vietnamese Catholics was held from December 10, 2008 to June 10, 2009 at the Vietnam Museum of Ethnology in Hanoi. The theme of this exhibition was “Catholic Culture as an Intrinsic Part of Vietnamese Culture.” The exhibition was organized by a State‐run museum against a background of difficult relations between the State and its Catholic communities. This article explores how the exhibition was conceived, and how the ideas of the curators were implemented by examining negotiations among different stakeholders involved in the exhibition. 相似文献
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Thi Quynh Trang Nguyen 《师资教育杂志》2015,41(2):203-214
In an East Asian context heavily influenced by Confucian ideas on principles for living and behaving, ‘face’ plays a significant role in Vietnamese people’s thinking and behaviour. In the context of education, Vietnamese teachers’ concerns of saving face in classrooms have been implicitly taken for granted but not yet seriously examined in academic research. The paper addresses this gap in the research literature by presenting the results of interviews with 15 lecturers in a Vietnamese Teacher Training College. It is argued that the concepts of face and saving face are significant to the participants and their ideas of saving face are largely influenced by traditional Confucian standards in education. In particular, teachers are believed to save face by upholding the belief that they represent an unquestionable source of knowledge, maintaining a ‘noble distant image’ in relations with their students, and receiving respectful behaviours from their students. These beliefs could be one source of resistance to educational reforms regarding interactive pedagogies in Vietnamese higher education. It is argued that teachers’ concerns of saving face in Vietnamese classrooms deserve more attention from educational planners and researchers. 相似文献
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Tertiary Education and Management - Significant changes in the policies of higher education in Vietnam have changed the structure and governance of the system since the mid-1990s. The most commonly... 相似文献