3,3′-Diindolylmethane Encapsulated Chitosan Nanoparticles Accelerates Inflammatory Markers,ER/PR,Glycoprotein and Mast Cells Population During Chemical Carcinogen Induced Mammary Cancer in Rats     

Stainsloss Isabella  Sankaran Mirunalini  Kannaiyan Pandiyan 《Indian journal of clinical biochemistry : IJCB》2018,33(4):397-405

The present study aimed to investigate the effect of 3,3′-diindolylmethane (DIM) on inflammatory markers, estrogen receptors (ER), progesterone receptors (PR), level of glycoprotein and the mast cell population in 7,12-dimethylbenz (a) anthracene (DMBA) 25 mg/kg b.wt. induced rat mammary carcinogenesis. After 8 weeks of tumor formation, rats had access to an oral administrated with DIM 10 mg/kg b.wt. and DIM@CS-NP 0.5 mg/kg body weight respectively for 8 weeks. The oral administration of DIM@CS-NP 0.5 mg/kg b.wt. suppressed the Cox-2, NF-κB and TNF-α protein expression on DMBA induced rats compared to DIM 10 mg/kg b.wt. The ER/PR levels were increased on DMBA induced rats, treated with DIM@CS-NP 0.5 mg/kg b.wt. reduced ER/PR level as well as glycoprotein and mast cell population than DIM 10 mg/kg b.wt. The result shows that, DIM@CS-NP 0.5 mg/kg b.wt. has the potentially inhibit abnormal levels of inflammatory markers, ER, PR, levels of glycoprotein and mast cell population compared to DIM 10 mg/kg b.wt.  相似文献   

Introducing medical students to radiological anatomy: The importance of experiential learning during the Covid-19 pandemic lockdowns     

Gustavo Bittencourt Camilo  Sérgio Murta Maciel  Gabriela Cumani Toledo Camilo  Kayan Felipe de Oliveira Andrade  Beatriz de Oliveira  Rayane da Silva Silveira  Isabella Nunes Borges Ferreira  Caroline da Silva Fernandes  Mariana Vilela Ferreira 《Anatomical sciences education》2022,15(5):980-984

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