Benzodiazepine administration prevents the use of error-correction mechanisms during fear extinction     

Genevra Hart  Nathan M. Holmes  Justin A. Harris  R. Frederick Westbrook 《Learning & behavior》2014,42(4):383-397

Three experiments examined the effect of systemic administration of the benzodiazepine midazolam on extinction and re-extinction of conditioned fear. Experiment 1 demonstrated that midazolam administration prior to extinction of a conditioned stimulus (CS) impaired that extinction when rats were subsequently tested drug free; however, extinction was spared if rats were extinguished, reconditioned, and re-extinguished under midazolam. Experiment 2 provided a replication of this effect within-subjects; rats were conditioned to two CSs (A and B), extinguished to one (A-), reconditioned to both, and then extinguished/re-extinguished to both stimuli in compound (AB-), under either vehicle or midazolam. On the drug-free test, rats given midazolam froze more to the CS that had been extinguished (B) than the one that been re-extinguished (A). The final experiment examined whether extinction under midazolam was regulated by prediction error. Rats were trained with three CSs (A, B, C) and extinguished to two (A-, C-). These stimuli then underwent additional extinction under midazolam or vehicle, with one CS now presented in compound with the non-extinguished CS (AB-, C-). Rats were then tested for fear of A relative to C. Rats given vehicle showed a deepening of extinction to A relative to C, as is predicted from error-correction models; however, rats given midazolam failed to show any such discrepancy in responding. The results are interpreted to indicate that the drug reduced prediction error during extinction by reducing fear, and rats were able to re-extinguish fear via a retrieval mechanism that is independent of prediction error.  相似文献   

Community Consultation in Developing Museum Projects: A Case Study Using the Repertory Grid Technique     

Ciara Canning & Kirsten Holmes 《Cultural Trends》2006,15(4):275-297

Good community consultation is a powerful tool in developing new museum projects and exhibitions, facilitating a more effective delivery of service to a diverse public. Existing techniques for both user and community consultation are limited with front end evaluation particularly undeveloped in the sector, often providing no meaningful base by which to compare project outcomes. Tension exists between government, which values quantitative data, and researchers who argue qualitative methods are more appropriate for evaluating community projects. This article reports a pilot study using the repertory grid technique to examine a ‘socially excluded’, ethnically diverse local community's perceptions, expectations and previous experiences of similar projects, to provide a benchmark against which to compare outcomes. This research formed part of the front end evaluation for a New Deal for Community's Project run by Sheffield Galleries and Museums Trust. The repertory grid technique was developed in psychological studies as a means of understanding respondents' own world views, and is particularly helpful in working with people with poor language skills. Although this study only used the technique qualitatively, it can be used to combine both quantitative and qualitative data, providing more robust data for evidence-based policy decisions. Using the repertory grid technique, respondents were able to list both perceived and practical barriers to participation in projects. The technique also enabled them to articulate what would motivate them to become involved in future projects. The repertory grid technique has significant potential for use in community consultation and project evaluation as a means of understanding local residents' perceptions and its visual representation means that its findings can be easily understood by participants, policy-makers and practitioners.  相似文献   

同义句转换精练     

曾国红 《英语辅导》2003,(7):7-7

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Joseph Lauwerys     

Brian Holmes 《Compare》1982,12(1):59-65

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Obituary     

Professor Brian Holmes 《Compare》1994,24(1):97-102

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Comment on Barrow     

Mark Holmes 《Interchange》1993,24(3):233-236

The author continues his dialogue with Robin Barrow on the place of religion in public education (see pages 205 to 223 of this issue).  相似文献   

Alive!     

Holmes B 《New scientist (1971)》2005,185(2486):28-33

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Models in Comparative Education     

Brian Holmes 《Compare》1981,11(2):155-161

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Vocabulary and syntactic structures in adapted "classics" readers for deaf children     

T L Layton  K J Schmucker  D W Holmes 《American annals of the deaf》1979,124(4):433-443

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The challenging academic development (CAD) collective     

Tai Peseta  Margaret Hicks  Trevor Holmes  Catherine Manathunga  Kathryn Sutherland  Susan Wilcox 《International Journal for Academic Development》2013,18(1):59-61

Nurse education is characterised by dissonance, ambiguity and uncertainty. Such a context makes demands on the educator's authenticity or sense of self. This paper reports an attempt to provide a space where dissonance, ambiguity and uncertainty could be held, tolerated and examined and where authenticity could be recovered or developed through the practice of artistry. Three art workshops were offered to eight nurse educators over a period of three months. Each of the participants and the co‐facilitator were subsequently interviewed. All welcomed the opportunity to find meaning in their practice and to be listened to in a climate of empathy, acceptance and congruence. They undertook novel activities that allowed for discovery and surprise. They explored their sense of self and coined fresh metaphors to communicate their experiences. The paper argues that there is room for approaches to academic staff development that go against the mainstream.

La formation des infirmières se caractérise par la dissonance, l'ambiguïté et l'incertitude. Un tel contexte exerce des pressions sur l'authenticité et le sens de soi d'un éducateur. Cet article rend compte d'une tentative de fournir un espace o[ugrave] l'authenticité peut être redécouverte et développée au moyen de la pratique artistique. Trois ateliers artistiques ont été offerts à huit formateurs d'infirmières sur une période de trois mois. Des entretiens ont été effectués auprès de chaque participant et du co‐facilitateur. Les répondants ont tous accueilli l'occasion de trouver un sens à leur pratique et de pouvoir être écouté dans un climat d'empathie, d'acceptation et d'harmonie. Ceux‐ci on entrepris des activités nouvelles faisant place à la découverte et à la surprise. Ils ont exploré leur sens de soi et ont trouvé de nouvelles métaphores pour communiquer leurs expériences. Cet article défend l'idée que des activités de développement pédagogique qui vont à l'encontre de la majorité ont leur place.  相似文献