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11.
The observation and assessment of quality of teacher–child interactions in elementary school settings are increasingly recognized as important; however, research is still very limited in European countries. In this study, we examined the quality of the interactions between teacher and children in first-grade classrooms in Portugal and the extent to which structural features at teacher-, classroom-, and school-level explained variation in this quality. One hundred fifteen classrooms participated in the study. Classrooms were observed through a standardized rating scale concerning emotional, organizational, and instructional support. Results indicated that the levels of emotional and organizational support in most classrooms were of moderate quality, but the levels of instructional support were low, suggesting that most observed activities did not encourage students’ higher-order thinking skills. An examination of the associations between teacher and classroom characteristics and the quality of teacher–child interactions indicated a small effect for teacher education. Teachers with an advanced degree were more likely to be more emotionally sensitive and to have better instructional interactions in the classroom. For school-level characteristics, findings showed that the classrooms in private and smaller schools were likely to provide higher levels of emotional, organizational, and instructional quality. The results suggest that focusing on the interactions between teacher and children can provide valuable information to enhance classroom quality.  相似文献   
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ABSTRACT

Leucine metabolites may reduce training-induced inflammation; however, there is scant evidence for this assertion. We conducted a double-blind randomized controlled pragmatic trial where 40 male participants were allocated into 4 groups: α-hydroxyisocaproic acid group ([α-HICA], n = 10, Fat-free mass [FFM] = 62.0 ± 7.1 kg), β-hydroxy-β-methylbutyrate free acid group ([HMB-FA], n = 11, FFM = 62.7 ± 10.5 kg), calcium β-hydroxy-β-methylbutyrate group ([HMB-Ca], n = 9, FFM = 65.6 ± 10.1 kg) or placebo group ([PLA]; n = 10, FFM = 64.2 ± 5.7 kg). An 8-week whole-body resistance training routine (3 training sessions per week) was employed to induce gains in skeletal-muscle thickness. Skeletal muscle thickness (MT), one repetition maximum (1RM), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and tumour necrosis factor alpha (TNF-α) were assessed at baseline and at the end of weeks 4 and 8. Time-dependent increases were detected from baseline to week 8 for MT (vastus lateralis: p = 0.009; rectus femoris: p = 0.018), 1RM (back squat: α-HICA, 18.5% ± 18.9%; HMB-FA, 23.2% ± 16%; HMB-Ca, 10.5% ± 13.8%; PLA, 19.7% ± 9% and bench press: α-HICA, 13.8% ± 19.1%; HMB-FA, 15.5% ± 9.3%; HMB-Ca, 10% ± 10.4%; PLA, 14.4 ± 11.3%, both p < 0.001), IL-6, hsCRP (both p < 0.001) and TNF-α (p = 0.045). No differences were found between groups at any time point. No leucine metabolite attenuated inflammation during training. Additionally, backwards elimination regressions showed that no circulating inflammatory marker consistently shared variance with the change in any outcome. Using leucine metabolites to modulate inflammation cannot be recommended from the results obtained herein. Furthermore, increases in inflammatory markers, from training, do not correlate with any outcome variable and are likely the result of training adaptations.  相似文献   
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This study used an individual structured interview to (1) verify the incidence of non-anthropocentric reasoning in 123 children attending the 3rd and 4th years in three primary schools in the Lisbon area (Portugal), when they are confronted with ecological dilemmas and (2) establish those places they frequented which permit animal contact. The results show a greater incidence of non-anthropocentric reasoning than that obtained in other international studies. This may be related to the focus of the questions asked, which invited children to imagine themselves as another animal or to present situations where human interaction is unfair. This incidence was found independently of gender, school origin and whether or not pets were owned, even with the more biologically complex animals. School year was the only variable proven to make a difference in conceptually more demanding questions. We also verified that the children's general past experience of nature is essentially aligned to ‘controlled environments depending on ongoing human management’, confirming a decline in direct contact with ‘natural and semi-natural environments’. However, this type of experience does not seem to exert a negative influence on their non-anthropocentric reasoning.  相似文献   
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When students reason during school science, they often refer to conceptions that are derived from out-of-school experiences and are poor proxies for science orthodoxy. However, for some areas of science, these conceptions represent only a proportion of students' full conceptual knowledge, for tacit understanding exists that is superior to the understanding displayed when reasoning. Noting that tacit understanding is engaged when events are judged as natural or non-natural, the paper is concerned with software that: (a) requires direction and speed of falling objects to be predicted, i.e. a typical science reasoning task that engages conceptual knowledge; (b) presents simulations of predicted motion in the expectation that its naturalness or non-naturalness would be recognised. An evaluation study is reported where children aged 8–12 years worked with the software in contexts that typify computer use in classrooms, i.e. individually under adult guidance (n =? 44 children) or in pairs with a classmate (n = 48 children). They were observed while they did this. Reasoning about object fall was assessed via change from individual pre-tests administered prior to software usage to individual post-tests administered a few weeks afterwards. The children who worked with the software showed greater pre- to post-test gains in conceptual understanding than control children (n =? 47 children), who lacked software experience. The gains were especially marked for the children who worked in pairs. The approach taken is contrasted with traditional approaches to conceptual change in school science, e.g. strategies that rely upon classroom experiments.  相似文献   
16.
Prostate cancer (PCa) incidence and mortality have decreased in recent years. Nonetheless, it remains one of the most prevalent cancers in men, being a disquieting cause of men's death worldwide. Changes in many cell signaling pathways have a predominant role in the onset, development, and progression of the disease. These include prominent pathways involved in the growth, apoptosis, and angiogenesis of the normal prostate gland, such as an- drogen and estrogen signaling, and other growth factor signaling pathways. Understanding the foundations of PCa is leading to the discovery of key molecules that could be used to improve patient management. The ideal scenario would be to have a panel of molecules, preferably detectable in body fluids, that are specific and sensitive biomarkers for PCa In the early stages, androgen deprivation is the gold standard therapy. However, as the cancer progresses, it even- tually becomes independent of androgens, and hormonal therapy fails. For this reason, androgen-independent PCa is still a major therapeutic challenge. By disrupting specific protein interactions or manipulating the expression of some key molecules, it might be possible to regulate tumor growth and metastasis formation, avoiding the systemic side effects of current therapies. Clinical trials are already underway to assess the efficacy of molecules specially designed to target key proteins or protein interactions. In this review, we address that recent progress made towards under- standing PCa development and the molecular pathways underlying this pathology. We also discuss relevant molecular markers for the management of PCa and new therapeutic challenges.  相似文献   
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This study focused on violent and prosocial behaviors by adolescents toward parents and teachers, and the relation between such behaviors and adolescents’ perceptions about the family and school environment. Gender differences in child‐to‐parent violence and student‐to‐teacher violence were also studied. The sample comprised 687 adolescents from secondary schools in the province of Gipuzkoa, Spain, aged between 12 and 16 years. Participants responded to the relationship domains of the Family Environment Scale and the Classroom Environment Scale, among other instruments. A positive family relationship was related to less violent and more prosocial behavior toward parents. However, a positive classroom relationship was associated only with more prosocial behavior toward teachers. The results show that criminal and antisocial behaviors had a mediating influence on the relation between family and school relationships and violence against authority. The implications for intervention and prevention programs are discussed.  相似文献   
18.
This pilot-study aimed to assess a psychoeducational program for staff in care homes. The program was designed to increase knowledge regarding dementia care, promote skills to integrate motor and multisensory stimulation in daily care, and develop coping strategies to manage emotional work-related demands. Six staff members received eight psychoeducational sessions held fortnightly and individualized assistance during the provision of morning care to six residents with dementia. An audio-recorded focus group interview with staff and video recordings of residents' behavior during morning care were made and used to assess the program. Staff reported several benefits: acquisition of new knowledge; demystification of preexisting beliefs related to dementia; group cohesion; self-worth feelings; and positive coping. A trend towards improvements at residents' levels of interaction was found. The findings suggest the need of interventions to go beyond the objectives exclusively centered on staff education and the promotion of residents' well-being. This should be achieved by also allowing workers to feel supported and empowered.  相似文献   
19.
Establishment of higher education institutions and new firm entry   总被引:1,自引:0,他引:1  
The presence of universities has generally been associated with technological entrepreneurship. But what is the real impact of new universities on the levels of firm creation in a region? The present paper uses policy evaluation methodologies and longitudinal data on the establishment of higher education institutions in Portuguese municipalities for the period 1992-2002 to examine its effect on entry rates of new firms in different sectors. We find that the establishment of a new university has a positive and significant effect on subsequent levels of knowledge based firm entry in municipalities, and a negative effect on the levels of entry in other sectors, such as low-tech manufacturing.  相似文献   
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