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Sunil Kumar Gupta R. C. Gupta Kapil Gupta H. P. Trivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(2):176-180
This study was conducted to find out the possible underlying mechanism of various manifestation of fluorosis, a disease caused
by excess ingestion of fluoride. For this the fluoride belt of Jaipur district was selected. The parameters selected were
serum Parathyroid hormone, the levels of which are directly affected by fluoride intake. The levels of serum seromucoid, serum
and leucocyte ascorbic acid, serum sialic acid (SSA) reflects ground substance metabolism. The study was conducted on two
hundred children, selected from four areas (50 from each area) consuming water containing 2.4, 4.6, 5.6 and 13.6 mg/l of fluoride.
Drinking water fluoride and serum fluoride were measured by Ion selective electrode method. Serum parathyroid by RIA and all
other parameters were measured spectrophotometrically. The results revealed an increase in levels of fluoride, parathyroid
hormone and seromucoid in serum with increasing water fluoride concentrations. Serum Calcium and serum ascorbic acid were
found in normal range, how ever leucocyte ascorbic acid were decreased. A high positive correlation among fluoride concentration
in drinking water and serum parathyroid hormone (r=0.967), and, serum parathyroid hormone and serum seromucoid concentration
(r=0.935) was also observed The results indicated that secondary hyperparathyroidism due to hypocalcemic stress caused by
excess fluoride ingestion disturbs normal metabolism of ground substance in calcified tissues of the body reflected as altered
levels of the components of ground substance in the serum. 相似文献
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Kapil D. Lahiri Himadri Datta Harendra N. Das 《Indian journal of clinical biochemistry : IJCB》2014,29(1):74-78
Hyperhomocysteinemia has been shown to be an independent risk factor for cardiovascular disease as well as retinal vascular occlusion. Because of the epidemiological, dietary, genetic and environmental diversity among the different countries, each country should establish the reference interval of homocysteine of their own population for recommending appropriate medical decision limits. Hence a total of 1,288 apparently healthy subjects including 636 male and 652 female were enrolled in the present study to determine the reference intervals of homocysteine in an Indian population. Results of the study were presented as mean, standard deviation, median and 2.5th and 97.5th percentile with the 0.90 confidence interval of each percentile values of homocysteine along with decade-wise changes. 相似文献
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