Acute and subacute oral toxicity of Litsea elliptica Blume essential oil in rats     

Siti Balkis Budin  Seri Masran Siti Nor Ain  Baharuddin Omar  Izatus Shima Taib  Othman Hidayatulfathi 《Journal of Zhejiang University. Science. B》2012,13(10):783-790

Litsea elliptica Blume has been traditionally used to treat headache, fever, and stomach ulcer, and has also been used as an insect repellent. The acute and subacute toxicities of L. elliptica essential oil were evaluated orally by gavage in female Sprague-Dawley rats. For the acute toxicity study, L. elliptica essential oil was administered in doses from 500 to 4 000 mg/kg (single dose), and in the subacute toxicity test, the following doses were used: 125, 250, and 500 mg/kg, for 28 consecutive days. In the acute toxicity study, L. elliptica essential oil caused dose-dependent adverse behaviours and mortality. The median lethal dose value was 3 488.86 mg/kg and the acute non-observed-adversed-effect level value was found to be 500 mg/kg. The subacute toxicity study of L. elliptica essential oil did not reveal alterations in body weight, and food and water consumptions. The haematological and biochemical analyses did not show significant differences between control and treated groups in most of the parameters examined, except for the hemoglobin, mean cell hemoglobin concentration, mean cell volume, mean cell hemoglobin, serum albumin, and serum sodium. However, these differences were still within the normal range. No abnormalities or histopathological changes were observed in the liver, pancreatic islet of Langerhans, and renal glomerulous and tubular cells of all treated groups. In conclusion, L. elliptica essential oil can be classified in the U group, which is defined as a group unlikely to present an acute hazard according to World Health Organization (WHO) classification.  相似文献   

Application of polyurethane geocomposites to help maintain track geometry for high-speed ballasted railway tracks     

Peter Keith Woodward  Abdellah El Kacimi  Omar Laghrouche  Gabriela Medero  Meysam Banimahd 《浙江大学学报(A卷英文版)》2012,13(11):836-849

There are many issues surrounding the performance of critical assets on high-speed ballasted railway lines. At assets like switch & crossings and bridge transitions high track forces can be produced resulting in higher ballast settlements and hence track misalignments. The latter result in higher track forces and hence more settlement, leading to the need for increased track maintenance to ensure comfort and safety. Current technologies for solving issues like ballast movement under high-speed loading regimes are limited. However, a technique that has been well used across the UK and now increasingly overseas to stabilise and reinforce ballasted railway tracks is the application of in-situ polyurethane polymers, termed XiTRACK. This paper discusses how this technique can be used to solve these types of long-standing issues and presents actual polymer application profiles at two typical critical sites, namely a junction and a transition onto concrete slab-track.  相似文献   

Action research for professional development: concise advice for new and experienced action researchers     

Yvon Appleby  Omar Aboo 《Studies in Continuing Education》2013,35(1):128-129

  相似文献   

Applying brand management to higher education through the use of the Brand Flux Model™ – the case of Arcadia University     

Robert L. Williams Jr.  Maktoba Omar 《Journal of Marketing for HIGHER EDUCATION》2013,23(2):222-242

Within an increasingly more competitive landscape, Higher Education Institutions (HEIs) are becoming more marketized and promotionalized. Brand building is becoming a strategic administrative goal, yet clear brand management models are lacking. This paper utilizes the Brand Flux Model^? to assist in tracking the fluxing nature or historical patterns of branding practices, and provides a graphic representation for following changes in branding or changes in position that result in either Reinforcing an existing brand, or Revitalizing, Refocusing, Renaming, or Retiring a brand. Through a case analysis of an HEI that eventually underwent a radical renaming, the various phases of the Brand Flux Model^? are explored and the critical aspect of ongoing brand management efforts is reinforced. The paper also highlights why periodic brand audits are necessary to ascertain that what the institution believes it is promoting and projecting is consistent with the actual brand image held by stakeholders, and suggests that benchmarking brand management efforts and correlating them with the stage and actions of the Brand Flux Model^? can assist in understanding branding as a growth platform for service organizations. For practitioners, this study provides a model to assist in brand management and renaming scenarios, and offers insight into channels for optimal corporate strategy. It demonstrates that making changes in branding or changes in position in order to Revitalize, Refocus (rebrand and reposition) or even Rename a brand, and then Reinforce those decisions, is critical to maintaining brand health.  相似文献   

Subject dispersion of LIS research in Pakistan     

Mirza Muhammad Naseer  Khalid Mahmood 《Library & information science research》2014

A subject analysis of 5195 publications in library and information science (LIS) research in Pakistan over a period of 62 years revealed that the majority of Pakistani LIS research focused on a few subject areas. Pakistani LIS researchers gave little attention to many subjects and completely ignored others. More than a quarter (26.72%) of the total items focused on “information treatment for information services” while 22% were related to “libraries as physical collections.” Other areas with some attention included “industry, profession and education” (12.32%) and “theoretical and general aspects of libraries and information” (11.40%). Researchers paid little attention to “housing technologies,” “technical services in libraries, archives and museums,” and “management.”  相似文献   

Library and Information Services in Pakistan:A Review of Articles Published in Foreign Journals     

Khalid Mahmood 《International Information and Library Review》1996,28(4):383-405

The paper presents a statistical and subjective review of the journal articles on various aspects of library and information services in Pakistan. Only the articles published in the journals outside Pakistan are included. Articles are selected from four abstracting services, i.e. LISA, ISA, LSA, and ERIC. Authorship characteristics of 97 articles are analysed and compared with the previous studies of LIS periodicals. Authorship details include collaboration, occupation, affiliation, and the author's country. Other publication details of the articles include year, language, journal, and the country of publication. The findings show that library science teachers write more than the other professionals and the most popular subject is the library and information science education. Library science faculty at Karachi University contributes more articles in international journals. The articles are mostly published in English language journals and in English speaking countries, i.e. UK and USA.International Information and Library Reviewpublished more articles on this topic. Problems in library research in Pakistan are discussed and recommendations are made. A brief review of the articles is given according to 16 major subjects. A bibliography of the articles reviewed is also compiled.  相似文献   

Cheating charge rocks malaria research     

Sattaur O 《New scientist (1971)》1983,97(1345):423

  相似文献   

Effect of high intensity ultrasound on the allergenicity of shrimp   总被引：4，自引：0，他引：4  

Li ZX  Lin H  Cao LM  Jameel K 《Journal of Zhejiang University. Science. B》2006,7(4):251-256

The tropomyosin fraction of shrimp proteins is potentially responsible for allergic reaction in individuals with genetic predisposition to allergy. However, there are no efficient and safe methods to reduce its allergenicity. High intensity ultrasound is known to change the structure of proteins. This study is aimed at assessing high intensity ultmsound＇s effect on the allergenicity of shrimp allergen. Shrimp and purified shrimp allergen were treated with high intensity ultrasound for 30-180 min. Extracts of treated samples were analyzed by enzyme-linked immunosorbent assay （ELISA） with pool serum of shrimp allergy patients and polyclonal anti-allergen antibodies and by immunoblotting after polyacrylamide gel electrophoresis. Shrimp treated with high intensity ultrasound showed a decrease in allergenicity measured with ELISA. A linear relationship between the immune response induced by treated shrimp allergen and the applied treatment time was observed. The decrease in allergenicity was confirmed by immunoblot assays with shrimp allergic patients serum. Allergenicity of shrimp allergen extracted from treated shrimp was higher than that of purified shrimp allergen with the same treatment time. Gel-filtration HPLC was applied for analysis of shrimp allergen after treatment with high intensity ultrasound. Some fractions were appeared with increasing treatment time. The results suggested that high intensity ultrasound could be used to reduce the allergenicity of shrimp.  相似文献   

Anti-allergic effects of ethanol extracts from brown seaweeds     

Haider Samee  Zhen-xing Li  Hong Lin  Jamil Khalid  Yong-chao Guo 《Journal of Zhejiang University. Science. B》2009,10(2):147-153

Ethanol extracts of brown seaweeds from Pakistan and China were isolated and compared for their antiallergenic activities.They included Sargassum tennerimum (ST) and Sargassum cervicorne (SC) from Pakistan,and Sargassum graminifolium turn (SG),Sargassum thunbergii (STH),and Laminariajaponica (LJ) from China.The ethanol extracts of these brown seaweeds were optimized at 85% (v/v) ethanol for the maximum yield of phlorotannin,an inhibitor against hyaluronidase.Total phlorotannins contained in the crude extracts were measured as 1.71% (SG),0.74% (STH),0.97% (LJ),3.30% (SC),and 5.06% (ST).The 50% inhibitory concentrations (IC50) of Pakistani SC and ST were 109.5 and 21 μg/ml,respectively,lower than those of Chinese SG,STH,and LJ (134,269,and 148 μg/ml,respectively).An antiallergic drug,disodium cromoglycate (DSCG),had an IC50=39 μg/ml,and a natural inhibitor of hyaluronidase,catechin,had an IC50=20 μg/ml.The IC50 of ST extract was found similar to that of catechin (21 vs 20 μg/ml) and lower than that of DSCG (21 vs 39 μg/ml).This suggests that ST is a potent inhibitor of hyaluronidase,indicating a promising future development of natural antiallergic medicines or functional foods.  相似文献   

It's a Whole New Ballgame: How Social Media is Changing Sports,J. Sanderson, 1st edition,Hampton Press,Inc., 307 Seventh Avenue,New York (2011), 121 pp,ISBN: 978-1-61289-053-1     

Khalid Ballouli 《Sport Management Review》2012,15(3):381-382

  相似文献