Convergent genomic signatures of high-altitude adaptation among domestic mammals     

Dong-Dong Wu  Cui-Ping Yang  Ming-Shan Wang  Kun-Zhe Dong  Da-Wei Yan  Zi-Qian Hao  Song-Qing Fan  Shu-Zhou Chu  Qiu-Shuo Shen  Li-Ping Jiang  Yan Li  Lin Zeng  He-Qun Liu  Hai-Bing Xie  Yun-Fei Ma  Xiao-Yan Kong  Shu-Li Yang  Xin-Xing Dong  Ali Esmailizadeh  David M Irwin  Xiao Xiao  Ming Li  Yang Dong  Wen Wang  Peng Shi  Hai-Peng Li  Yue-Hui Ma  Xiao Gou  Yong-Bin Chen  Ya-Ping Zhang 《国家科学评论(英文版)》2020,7(6):952

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.  相似文献   

Disaggregated Effects of Device on Score Comparability          下载免费PDF全文

Laurie Davis  Kristin Morrison  Xiaojing Kong  Yuanyuan McBride 《Educational Measurement》2017,36(3):35-45

The use of tablets for large‐scale testing programs has transitioned from concept to reality for many state testing programs. This study extended previous research on score comparability between tablets and computers with high school students to compare score distributions across devices for reading, math, and science and to evaluate device effects for gender and ethnicity subgroups. Results indicated no significant differences between tablets and computers for math and science. For reading, a small device effect favoring tablets was found for the middle to lower part of the score distribution. This effect seemed to be driven by increases in performance for male students when testing on tablets. No interactions of device with ethnicity were observed. Consistent with previous research, this study provides additional evidence for a relatively high degree of comparability between tablets and computers.  相似文献   

Bringing the State Back In: restoring the role of the State in Chinese higher education     

Ka Ho Mok 《European Journal of Education》2012,47(2):228-241

In the last few decades, in the wake of three major crises in political faith and the overall instability that followed the end of the Cultural Revolution, the post-Mao Chinese government has sought to improve the lives of its citizens and to restore political legitimacy through rapid economic growth that has focused almost exclusively on GDP. This strong focus has brought about rapid, widespread economic growth to China, and has, by classical market standards, been a success. At the same time, issues of social development and human well-being have received less attention. Before the Hu-Wen leadership's formal accession to power, the Jiang-Zhu administration sought to adopt neo-liberal ideas and practices to reform the delivery of social services and the implementation and funding of social policy. In this context, major fields of social policy such as health, education, and housing have been going through the processes of marketisation and privatisation, which have placed much of the financial burden of meeting these social welfare needs on China's citizens. After several decades of privatisation and marketisation in the educational system, the Chinese government has been the subject of repeated criticism for failing to tackle what is popularly known as the ‘new three mountains phenomenon’, namely, the rising cost of health, education, and housing in recent years. Against the wider policy context described above, this article examines the social and political consequences of the privatisation and marketisation of education. It also discusses the major policies and strategies recently adopted by the Chinese government to restore the role of the State in the education system in order to address the negative consequences of the privatisation of education. Finally, it critically examines the main implications of major reforms undertaken in higher education in Mainland China.  相似文献   

近十年我国在职人员继续教育模式研究综述     

孔德丰  刘凤存 《职教通讯》2012,(31):37-41

回顾近十年我国在职人员继续教育模式研究所呈现的一些特点,并对其做出简要评价,对今后我国在职人员继续教育模式未来趋势进行宏观展望。今后我国在职人员继续教育模式将会出现目标多元化、课程融合化、机制市场化、手段网络化以及进程终身化等特点。  相似文献   

A conceptual change approach to staff development: A model for programme design     

Angela S P Ho 《International Journal for Academic Development》2013,18(1):30-41

With the rapid expansion in tertiary education in the past decade, coupled with the rising emphasis on accountability, teaching quality has become an important issue in higher education worldwide. The increasing emphasis on quality has placed new demands on staff development, in particular to find promising models and methodologies that will guide development approaches. The paper describes an innovative approach to staff development that was synthesized from four theories about conceptual change or change in general. This conceptual change approach is based on the hypothesis that changing teachers' conceptions of teaching towards more elaborated levels will bring about improvement in their teaching practices. A short course derived from this model is outlined.  相似文献   

学科信息门户:概念、结构与关键技术   总被引：15，自引：0，他引：15  

孔敬  李广建 《中国图书馆学报》2005,31(5)

以信息与应用高度集成、个性化和智能化为显著特征的新一代学科信息门户系统框架正在成为构建基于WWW的专业数字图书馆的理想模式。网络信息技术如门户构件、跨系统集成检索、元搜索引擎和智能代理等技术的迅速发展,为构建学科信息门户提供了关键技术支撑。图4。参考文献9。  相似文献   

对图书馆OPAC分类数据的分析     

鞠福琴  孔为民 《图书馆学研究》2007,(7):41-42,7

本文指出了OPAC分类数据中存在的问题，并对存在问题的原因进行了剖析，提出了改进建议。  相似文献   

浅析基于点击呼叫的网络营销     

孔胜军  张晓娜 《中国科技资源导刊 (中国信息导报)》2007,(7):54-57

点击呼叫是电子商务时代最流行的新型语音通讯工具,必将成为未来网络营销发展的新趋势。首先介绍点击呼叫的概念和特点,然后详细分析在网络营销活动中实施点击呼叫服务的必要性、可行性,并论述点击呼叫对网络营销的影响,最后探讨性地提出基于点击呼叫的网络营销模式以及实现条件。  相似文献   

高职数学教学的现状及改革探索     

孔翠翠  孔姗姗 《中国教育技术装备》2010,(18):41-42

高职数学教学面临着课时少、任务重、学生素质差的现状和问题,根据高职教育的培养目标,教学改革势在必行.为此,对高职数学教学的指导思想、教学内容、教学方法和评价机制的改革等方面进行系统的理论探讨.  相似文献   

图书馆特色馆藏建设的实践   总被引：1，自引：0，他引：1  

覃凤兰  孔祥平  段运 《新世纪图书馆》2010,(1):25-27

湛江师范学院图书馆根据读者需求，在现有文献资源基础上深入挖掘本地、本馆资源，搜集整合网络资源，建立了15个具有本地特色的数据库，同时还建立了特藏阅览室。  相似文献