Entrepreneurial higher education institutions: Development of the research and future directions     

Raihan Taqui Syed  Dharmendra Singh  David Spicer 《Higher Education Quarterly》2023,77(1):158-183

  相似文献   

Language non-selective activation of orthography during spoken word processing in Hindi–English sequential bilinguals: an eye tracking visual world study     

Ramesh Kumar Mishra  Niharika Singh 《Reading and writing》2014,27(1):129-151

  相似文献   

Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis     

Sheng-chun DANG  Yan-hua ZENG  Ping-jiang WANG  Bao-ding CHEN  Rong-fang CHEN  Arun KUMAR SINGH  Pankaj KUMAR  Shu FENG  Lei CUI  Hao WANG  Jian-xin ZHANG 《Journal of Zhejiang University. Science. B》2014,15(6):556-565

Background and objective

It has been shown that macrophages play an important role in the development of severe acute pancreatitis (SAP), and eventually lead to multiple organ failure (MOF). Clodronate-liposome selectively depleted macrophages. This study was to investigate the role of renal macrophage infiltration in acute renal injury in rats with SAP and to evaluate the potential of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) for diagnosis.

Methods

Superparamagnetic Fe₃O₄ nanoparticles were prepared by chemical coprecipitation. SPIO-liposomes and SPIO-clodronate-liposomes were prepared by the thin film method. SAP models were prepared by injection of sodium taurocholate into the subcapsular space of rat pancreas. Sprague-Dawley rats were randomly divided into a control group, SAP plus SPIO-liposome (P) group, and SAP plus SPIO-clodronate-containing liposome (T) group. Kidney injury was evaluated by T2-weighted MRI scan. The levels of serum amylase (SAM), blood urea nitrogen (BUN), and serum creatinine (SCr) were measured by an automated enzymatic method. Serum tumor necrosis factor-α (TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA). Pathological changes in the pancreas and kidney were observed using hematoxylin and eosin (H&E) staining, while cell apoptosis was detected with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. In addition, the macrophage markers (CD68) of the renal tissue were detected with immunohistochemistry.

Results

The pathological changes in the pancreas and kidneys of rats in the T group were milder than those in the P group. The MRI signal intensity of the kidneys in the P and T groups was significantly lower than that in the control group. There were significant changes in the two experimental groups (P<0.01). The levels of SAM, Bun, SCr, and TNF-α in rats in the P group were higher than those in the control group (P<0.01) and in the T group (P<0.01). The apoptosis of the kidney in the T group was higher than that in the P group at 2 and 6 h (P<0.01).

Conclusions

Clodronate-containing liposomes protected against renal injury in SAP rats, and SPIO can be used as a tracer for MRI examination to detect renal injury in SAP rats. SPIO-aided MRI provided an efficient non-invasive way to monitor the migration of macrophages after renal injury in rats with SAP.  相似文献   

反复张力下V形切口圆条的表面裂纹的疲劳扩展     

Devi CHANDRA  ;Judha PURBOLAKSONO  ;Yusoff NUKMAN  ;Haw-ling LIEW  ;Singh RAMESH  ;Mohsen-abdel HASSAN 《浙江大学学报(A卷英文版)》2014,15(11):873-882

研究目的：在相同的反复张力下,研究V形切口圆条表面裂纹的疲劳扩展规律。研究方法：1.构建V形切口圆条模型（图1）,基于线性二次元将模型表面离散成一个个网格点（图2）;2.以AZ-6A-T5镁合金为例,利用J积分计算应力强度因数,利用NASGRO裂纹增长率模拟裂纹的疲劳扩展;3.通过研究不同的裂纹纵横比和对应的应力强度因数之间的相关性来研究裂纹的扩展。重要结论：1.在裂纹扩展时裂纹纵横比的初始值对断裂形状的发展有重要影响;2.裂纹纵横比对疲劳负荷寿命的作用比缺口半径更加明显;3.当裂纹前缘演变成一条直线形时可观察到不稳定的裂纹扩展;4.裂纹深度一定时,断裂纵横比越小,疲劳负荷寿命越短;5.当裂纹纵横比为0.6-0.7时,出现了不稳定的裂纹扩展。  相似文献   

Critical perspectives on testing teaching: reframing teacher education for English medium instruction     

Da-Fu Huang  Michael Singh 《Asia-Pacific Journal of Teacher Education》2014,42(4):363-378

The investigation reported here provides a basis for considering the role of corrective and transformative critiques in producing knowledge through testing teaching for reframing teacher education in response to, and as an expression of, the globalisation of English. This knowledge-producing approach to critique begins with a literature review of prior testing models of content and language integrated learning through English medium instruction (EMI) programmes. Delphi procedures were employed with a panel of 30 experts from three focus groups, namely teachers, testing experts, and teacher evaluation administrators. A comparison of relative importance of the indicators generated through this study via the analytic hierarchy process yielded practical implications for reframing the internationalisation of education using EMI. The analysis of interviews with teachers was used to critically rework or otherwise correct the testing model. Through adopting the practice of critique as a knowledge-producing venture, this study offers a model of EMI testing that can contribute to improvements in the organisation of professional learning and change, as well as certification procedures.  相似文献   

Extracurricular Activities,Screen Media Activity,and Sleep May Be Modifiable Factors Related to Children’s Cognitive Functioning: Evidence From the ABCD Study®     

Namik Kirlic  Janna M. Colaizzi  Kelly T. Cosgrove  Zsofia P. Cohen  Hung-Wen Yeh  Florence Breslin  Amanda S. Morris  Robin L. Aupperle  Manpreet K. Singh  Martin P. Paulus 《Child development》2021,92(5):2035-2052

This study used a machine learning framework in conjunction with a large battery of measures from 9,718 school-age children (ages 9–11) from the Adolescent Brain Cognitive Development^SM (ABCD) Study to identify factors associated with fluid cognitive functioning (FCF), or the capacity to learn, solve problems, and adapt to novel situations. The identified algorithm explained 14.74% of the variance in FCF, replicating previously reported socioeconomic and mental health contributors to FCF, and adding novel and potentially modifiable contributors, including extracurricular involvement, screen media activity, and sleep duration. Pragmatic interventions targeting these contributors may enhance cognitive performance and protect against their negative impact on FCF in children.  相似文献   

Risk of Eating Disorders Among Female College Athletes and Nonathletes     

Ginger Kirk  Kusum Singh  Hildy Getz 《Journal of College Counseling》2001,4(2):122-132

This study compared the prevalence of eating disorder behaviors between female collegiate athletes (n = 206) and female college nonathletes (n = 197). Although female nonathletes had somewhat higher average scores on the Eating Attitudes Test 26, the proportion at risk for disordered eating was not different in the 2 groups. There was no significant difference among female athletes in different sports. Younger women were found to have more symptoms of disordered eating than did older women.  相似文献   

Teacher‐identity Formation through Language Immersion in an Initial‐teacher‐education Curriculum     

Leo Bartlett  Tony Erben  Michael Garbutcheon‐Singh 《Asia-Pacific Journal of Teacher Education》1996,24(2):173-196

  相似文献   

Conducting Indigenous research in Western knowledge spaces: aligning theory and methodology     

Myra Singh  Jae Major 《The Australian Educational Researcher》2017,44(1):5-19

Walking simultaneously in two worlds as an Indigenous researcher, navigating Indigenous and Western epistemologies/methodologies can have its challenges. Indigenous methodologies have become an important element of qualitative research and have been increasingly taken up by both Indigenous and non-Indigenous researchers. Indigenous methodologies seek to ensure that the research is culturally safe and culturally respectful through recognition of Indigenous worldviews, respect, and accountability. It is no longer research on or about Indigenous people, rather it is becoming research for and with Indigenous people. In this paper, we reflect on the experiences of an Indigenous researcher working with a non-Indigenous supervisor within an overarching Western theoretical framework of poststructuralism while also using Indigenous methodologies. We discuss the tensions and points of connection that emerged in the research design process. We suggest that Indigenous and Western epistemologies/methodologies do not have to be used to the exclusion of each other; they can be used effectively to complement and support each other.  相似文献   

A Practical Introduction to Authoring for Computer-Assisted Instruction. Part 5: PHILVAS     

Philip Barker  Ravinder Singh 《British journal of educational technology : journal of the Council for Educational Technology》1985,16(3):218-236

Interactive videodisc technology is likely to have a significant impact upon many aspects of education and training. However, before this medium can be effectively utilized considerable attention must be given to overcoming the present problems associated with courseware authoring. Solutions to these problems are to be found in the provision of suitable courseware development aids. In particular, there is a requirement for a powerful and easy-to-use author language. This paper describes the approach used by the PHILVAS authoring system.  相似文献