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排序方式： 共有149条查询结果，搜索用时 31 毫秒
91.
Emil List Larsen Henrik Enghusen Poulsen Cristina Michaelsen Laura Kofoed Kjær Mark Lyngbæk Emilie Skytte Andersen 《Journal of sports sciences》2020,38(18):2080-2091
ABSTRACT
Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2?-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h, P < 0.01) and 8-oxoGuo (-5.8 (95% CI -10.3;-1.3) nmol/24 h, P = 0.02) was observed. The excretion rate of 8-oxodG remained decreased 7 days after the marathon compared to baseline (-2.3 (95%CI -4.3;-0.4) nmol/24 h, P = 0.02), whereas the excretion rate of 8-oxoGuo was normalized. In conclusion marathon participation immediately induced a considerable inflammatory response, but did not increase excretion rates of oxidatively generated nucleic acid modifications. In fact, a delayed decrease in oxidatively generated nucleic acid modifications was observed suggesting adaptive antioxidative effects following exercise. 相似文献
92.
93.
ABSTRACTThere are quite a few challenges in the development of an automated writing placement model for non-native English learners, among them the fact that exams that encompass the full range of language proficiency exhibited at different stages of learning are hard to design. However, acquisition of appropriate training data that are relevant to the task at hand is essential in the development of the model. Using the Cambridge Learner Corpus writing scores, which have been subsequently benchmarked to Common European Framework of Reference for Languages (CEFR) levels, we conceptualize the task as a supervised machine learning problem, and primarily focus on developing a generic writing model. Such an approach facilitates the modeling of truly consistent, internal marking criteria regardless of the prompt delivered, which has the additional advantage of requiring smaller dataset sizes and not necessarily requiring re-training or tuning for new tasks. The system is developed to predict someone’s proficiency level on the CEFR scale, which allows learners to point to a specific standard of achievement. We furthermore integrate our model into Cambridge English Write & ImproveTM—a freely available, cloud-based tool that automatically provides diagnostic feedback to non-native English language learners at different levels of granularity—and examine its use. 相似文献
94.
Rebekka Andersen 《Technical Communication Quarterly》2013,22(1):61-87
This article lays out some of the key issues driving organizations' increasing interest in enterprise content management (ECM). It then problematizes both the rhetoric that technology developers are using to sell ECM technologies to business leaders and the assumptions on which business leaders are basing critical technology implementation decisions. Finally, it argues why technical communicators must take action—through direct participation in the ECM discourse—to shift the rhetoric that is structuring the ECM debate and thus shaping the potential of the field of technical communication. 相似文献
95.
Social media in public health care: Impact domain propositions 总被引：1，自引：0，他引：1
This paper investigates the impacts of social media use in Danish public health care with respect to capabilities, interactions, orientations, and value distribution. Taking an exploratory approach, the paper draws on an array of quantitative and qualitative data, and puts forward four propositions: social media transform the access to health-related information for patients and general practitioners, the uptake of social media can be a cost driver rather than a cost saver, social media provide empowerment to patients, and the uptake of social media is hindered by legal and privacy concerns. 相似文献
96.
97.
Melissa N. Andersen Edward J. Daly III Nicholas D. Young 《Psychology in the schools》2013,50(4):403-414
This study sought to evaluate whether a one‐trial brief experimental analysis (OTBEA) would reliably and validly identify effective treatments to improve oral reading fluency for 6 elementary school students referred for reading problems. An OTBEA was conducted with each participant to assess the effects of skill‐ and performance‐based treatment components. Following the OTBEA, an extended analysis was conducted using an alternating treatments design to experimentally assess whether predictions generated by the OTBEA would be accurate across sessions, time, and stimulus materials. OTBEA results suggested that 3 participants required a treatment package containing both performance‐based and skill‐based instructional components and that the other 3 participants might only need performance‐based interventions. Results indicate that predictions were accurate for those participants requiring both types of intervention components, but that predictions for the remaining participants met with mixed results in the extended analysis. Results are discussed in terms of further refining brief experimental analysis methods to make them more efficient for educators while ensuring valid results. 相似文献
98.
Magnus Dencker Ola Thorsson Magnus K. Karlsson Christian Lindén Per Wollmer L. B. Andersen 《Journal of sports sciences》2013,31(13):1397-1402
Abstract Maximal oxygen uptake ([Vdot]O2max) is considered the optimal method to assess aerobic fitness. The measurement of [Vdot]O2max, however, requires special equipment and training. Maximal exercise testing with determination of maximal power output offers a more simple approach. This study explores the relationship between [Vdot]O2max and maximal power output in 247 children (139 boys and 108 girls) aged 7.9–11.1 years. Maximal oxygen uptake was measured by indirect calorimetry during a maximal ergometer exercise test with an initial workload of 30 W and 15 W · min?1 increments. Maximal power output was also measured. A sample (n = 124) was used to calculate reference equations, which were then validated using another sample (n = 123). The linear reference equation for both sexes combined was: [Vdot]O2max (ml · min?1) = 96 + 10.6 · maximal power + 3.5 · body mass. Using this reference equation, estimated [Vdot]O2max per unit of body mass (ml · min?1 · kg?1) calculated from maximal power correlated closely with the direct measurement of [Vdot]O2max (r = 0.91, P <0.001). Bland-Altman analysis gave a mean limits of agreement of 0.2±2.9 (ml · min?1 · kg?1) (1 s). Our results suggest that maximal power output serves as a good surrogate measurement for [Vdot]O2max in population studies of children aged 8–11 years. 相似文献
99.
Abstract This paper examines the effect of participating in a web-based health programme that promotes personal tracking of high school students’ own measurements of a number of health-related parameters. Danish cross-sectional survey data were used to examine the effects of the health programme on various health measures. Both quantile regression models and standard ordinary least squares (OLS) models were used to explore the correlations between the students’ participation in the health programme and their body mass index (BMI), body fat percentage, aerobic fitness, and well-being. Participation in the health programme increased BMI and aerobic fitness among students with a BMI or an aerobic fitness value ranging from the 25th percentile to the 75th percentile and reduced body fat percentage among students with the highest percentages of body fat. In addition, the health programme led to an increased feeling of wellbeing among students, especially those with high BMI levels and poor aerobic fitness. As the schools participated in the health programme on voluntary basis and at a financial cost to themselves, the positive effects of participation found can only be stated to be valid among students from committed schools. 相似文献
100.
The Danish e-commerce strategy is a highly ambitious effort to become the world's leading IT nation. Instead of a production-led approach aimed at stimulating domestic hardware and software production, Denmark has pursued a demand-oriented approach focused on promoting the widespread adoption of e-commerce in the Danish society. The Danish government has developed a number of e-commerce initiatives via public-private sector partnerships--an approach we refer to as "governance." So far, it appears that Denmark has been successful in promoting business-to-business (B2B) e-commerce, with a number of Danish companies being global leaders in the use of B2B applications. On the other hand, Denmark has had less success in achieving widespread use of business-to-consumer (B2C) e-commerce. This article analyzes the Danish national environment for e-commerce, discusses four sets of governance initiatives aimed at the development of e-commerce, and analyzes the reasons for its success in B2B and relative failure in B2C adoption. 相似文献