Vanishing species: The planet in crisis     

Uttam Saikia  Narayan Sharma  Abhijit Das 《Resonance》2010,15(4):321-336

Rapid extinction of species is one of the most serious ecological problems faced by humanity today. Species are disappearing at a pace unprecedented in the history of the planet putting the very future of life at risk. The irony is that the root of the crisis is another species, Homo sapiens rather than some physical events that is poised to threaten its own survival. This article gives a brief introduction to the crisis, its consequences and possible mitigation strategies.  相似文献   

Symmetries of particle physics: Space-time and local gauge symmetries     

Sourendu Gupta 《Resonance》2001,6(2):29-38

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Federal support for art —An economic analysis     

Amaresh Das 《Journal of Cultural Economics》1979,3(2):89-97

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Filaria associated clinical manifestations in children in an endemic area and morbidity control by immunomonitoring and optimal DEC therapy: Sevagram experience     

B. C. Harinath  M. V. R. Reddy  B. Bhunia  Y. P. Bhandari  V. K. Mehta  P. Chaturvedi  N. C. Prajapati  R. K. C. Gupta 《Indian journal of clinical biochemistry : IJCB》2000,15(1):118-126

Lymphatic filariasis is a major public health problem in India with 412 million people living in bancroftian endemic areas and is a major cause of clinical morbidity. Twenty million people are reported to suffer from chronic disease manifestations such as lymphoedema, hydrocele or elephantiasis. At least twice the number have been shown to suffer from acute and occult filarial infections in an endemic area without diagnosis. Due to non-availability of suitable diagnostic test for confirming filaria aetiology other than parasitological examination, no significant study on filariasis in children has been reported earlier. Studies in our laboratory for more than a decade showed usefulness of microfilarial excretory-secretory antigen in confirming filarial aetiology in acute and occult infections in adults as well as in children. This study reports acute and atypical manifestations such as lymphadenopathy, asthmatic bronchitis, pulmonary eosinophilia, mono-arthritis, recurrent URI, pneumonia, nutritional anemia, pain in abdomen etc. in children living in filaria endemic area having no microfilaraemia but showing filaria aetiology by immunomonitoring for the presence of antibody or antigen and responding to optimal DEC therapy.  相似文献   

Hyperhomocysteinemia and cardiovascular disease: The nutritional perspectives     

Rajesh Pandey  Seema Gupta  Harbans Lal  H. C. Mehta  S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2000,15(1):20-30

Several members of the vitamin B-complex family are known to participate in the normal metabolism of homocysteine (Hcy). Leaving aside the genetic determinants of hyperhomocysteinemia (HHC), the deficiencies of these vitamins can also result in HHC. The situation of sustained and long standing HHC is likely to be prevalent in population groups with low/average socio-economic status, geriatric population and alcohol abusers. If not corrected by supplementation, these population groups certainly are more vulnerable to develop atherosclerosis (AS) and subsequently, cardiovascular disease (CVD). Hyperhomocysteinemia per se and/or HHC-induced oxidative stress result(s) in chronic chemical endothelial injury/dysfunction, smooth muscle proliferation, prothrombotic state and oxidation of low density lipoproteins (LDL) leading to diverse cardiovascular complications. In the first decade of the new millennium, major research efforts would be directed towards understanding the basic mechanism of HHC-induced oxidative stress and the pathophysiology of HHC-induced CVD, culminating in the evolution of hitherto unknown therapeutic strategies such as nutriceuticals and oxidant-antidotes.  相似文献   

A microfluidic platform for studying the effects of small temperature gradients in an incubator environment     

Sarit K. Das  Seok Chung  Ioannis Zervantonakis  Joseph Atnafu    Roger D. Kamm 《Biomicrofluidics》2008,2(3)

Studies on the effects of variations in temperature and mild temperature gradients on cells, gels, and scaffolds are important from the viewpoint of biological function. Small differences in temperature are known to elicit significant variations in cell behavior and individual protein reactivity. For the study of thermal effects and gradients in vitro, it is important to develop microfluidic platforms which are capable of controlling temperature gradients in an environment which mimics the range of physiological conditions. In the present paper, such a microfluidic thermal gradient system (μTGS) system is proposed which can create and maintain a thermal gradient throughout a cell-seeded gel matrix using the hot and cold water supply integrated in the system in the form of a countercurrent heat exchanger. It is found that a uniform temperature gradient can be created and maintained in the device even inside a high temperature and high humidity environment of an incubator. With the help of a hot and cold circuit controlled from outside the incubator the temperature gradient can be regulated. A numerical simulation of the device demonstrates the thermal feature of the chip. Cell viability and activity under a thermal gradient are examined by placing human breast cancer cells in the device.  相似文献   

Tumor necrosis factor alpha (TNF-α) and estrogen hormone in osteoarthritic female patients     

Pradeep Sharma  Neelima Singh  Vinod Singh  Sanjeev Singh  Harsh vardhan Singh  Sameer Gupta 《Indian journal of clinical biochemistry : IJCB》2006,21(1):205-207

Osteoarthritis of knee joints is a disease of old age in both sex. It is very common after the age of 40 years in elderly females or in postmenopausal phase of females. It is characterized by narrowing of space in joints due to inflammation. The exact mechanism of inflammation in this disease is not yet clear. Tumor necrosis factor alpha (TNF-α) may involve in onset of disease. The present study is being carried out in 130 female subject of age group 40–60 years suffering from osteoarthritis of knee joints and 50 normal healthy control female subjects. A correlation is made between TNF-α and estrogen and found significant inverse correlation (r<0.001), between TNF-α and estrogen hormone in osteoarthritic female patients as compared to normal healthy control female group.  相似文献   

Nanopore Technology: A Simple,Inexpensive, Futuristic Technology for DNA Sequencing     

P. D. Gupta 《Indian journal of clinical biochemistry : IJCB》2016,31(4):359-360

In health care, importance of DNA sequencing has been fully established. Sanger’s Capillary Electrophoresis DNA sequencing methodology is time consuming, cumbersome, hence become more expensive. Lately, because of its versatility DNA sequencing became house hold name, and therefore, there is an urgent need of simple, fast, inexpensive, DNA sequencing technology. In the beginning of this century efforts were made, and Nanopore DNA sequencing technology was developed; still it is infancy, nevertheless, it is the futuristic technology.  相似文献   

Applying Conceptual Blending to Model Coordinated Use of Multiple Ontological Metaphors     

Benjamin W. Dreyfus  Ayush Gupta  Edward F. Redish 《International Journal of Science Education》2015,37(5-6):812-838

Energy is an abstract science concept, so the ways that we think and talk about energy rely heavily on ontological metaphors: metaphors for what kind of thing energy is. Two commonly used ontological metaphors for energy are energy as a substance and energy as a vertical location. Our previous work has demonstrated that students and experts can productively use both the substance and location ontologies for energy. In this paper, we use Fauconnier and Turner's conceptual blending framework to demonstrate that experts and novices can successfully blend the substance and location ontologies into a coherent mental model in order to reason about energy. Our data come from classroom recordings of a physics professor teaching a physics course for the life sciences, and from an interview with an undergraduate student in that course. We analyze these data using predicate analysis and gesture analysis, looking at verbal utterances, gestures, and the interaction between them. This analysis yields evidence that the speakers are blending the substance and location ontologies into a single blended mental space.  相似文献   

Understanding teachers’ concerns about inclusive education     

Monika Yadav  Ajay Das  Sushama Sharma  Ashwini Tiwari 《Asia Pacific Education Review》2015,16(4):653-662

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