Serum Lipid Alterations in Early Rheumatoid Arthritis Patients on Disease Modifying Anti Rheumatoid Therapy     

Sana Parveen  Rachel Jacob  Liza Rajasekhar  C. Srinivasa  Iyyapu Krishna Mohan 《Indian journal of clinical biochemistry : IJCB》2017,32(1):26-32

Dyslipidaemia is a major CVD risk factor in the general population. Current evidence suggests that lipid metabolism is altered in RA due to inflammation, and that use of anti-inflammatory therapy may reverse some of these changes. The objective of our study is to compare the effect of treatment with DMARD on lipid fractions after 6 months of therapy. Forty patients who met the American College of Rheumatology, ACR/EULAR criteria for rheumatoid arthritis, with disease duration of less than 1 year and no prior treatment were included in the study. Thirty healthy volunteers were included as controls. The mean DAS-28 at disease onset was 5.15 ± 1.3. Early Rheumatoid Arthritis (ERA) patients exhibited higher serum levels of total cholesterol (TC) and lowdensity lipoprotein cholesterol (LDL-C) and lower serum high-density lipoprotein cholesterol (HDL-C) levels compared to controls. As a consequence, the atherogenic index of plasma [log (TG/HDL-C)], the atherogenic indices: TC/HDL-C as well as LDLC/HDL-C was significantly higher in ERA patients compared to controls. After 6 months of treatment, there was significant reduction of the DAS 28, HDL-C and Apo A-I improved and Lp(a) decreased significantly. All lipid ratios improved, a phenomenon primarily due to the increase in serum HDL-C levels. These changes were inversely correlated with CRP and ESR. In conclusion, ERA patients are characterized by an atherogenic lipid profile, which improves with DMARD therapy.  相似文献   

Exploring alternative assessments for signing deaf candidates     

Rachel O'Neill  Audrey Cameron  Eileen Burns  Gary Quinn 《Psychology in the schools》2020,57(3):344-361

Attitudes to sign languages or language policies are often not overtly discussed or recorded but they influence deaf young people's educational opportunities and outcomes. Two qualitative studies from Scotland investigate the provision of British Sign Language as accommodation in public examinations. The first explores the views of deaf pupils and staff about the official system for face-to-face interpretation of exam papers. The second investigates a centrally translated digital paper with embedded video questions. Discussion focuses on contrasts between the USA and UK approaches to accommodations, raising issues of standardized technical terms in signed languages, the right to respond in sign, and candidate choice.  相似文献   

Breaking down buy-in: Can lessons from social psychology increase teacher use of proactive behavior management?     

Rachel E. Robertson 《Psychology in the schools》2020,57(11):1771-1786

Disruptive student behavior poses significant challenges for teachers and is associated with negative student outcomes. Research shows that teacher use of empirically-based proactive behavior management (PBM) can improve student outcomes; however, research also indicates that teacher use of PBM is low. One prominent factor in teacher use of PBM is “buy-in,” or personal interest, agreement, and investment in the implementation of a practice. When teachers buy in to an intervention, they may be more likely to implement and maintain the intervention with fidelity. Yet, there is little empirically-based understanding of buy-in or strategies known to increase the buy-in of school staff. The purpose of this paper is to describe research from social psychology that may be useful in developing a theoretical framework for buy-in, as well as approaches to increasing teacher buy-in and use of PBM. Implications for incorporating strategies from social psychology into teacher professional development to increase buy-in and use of PBM are discussed.  相似文献   

Plain language summaries: Enabling increased diversity,equity, inclusion and accessibility in scholarly publishing     

Adeline Rosenberg  Joanne Walker  Sarah Griffiths  Rachel Jenkins 《Learned Publishing》2023,36(1):109-118

• Plain language summaries (PLS) are accessible, short, peer-reviewed summaries of scholarly journal articles written in non-technical language.
• The aim of PLS is to enable a broader audience of experts and non-experts to understand the original article.
• Here, we outline the evidence base for the value and impact of PLS and how they can enable diversity, equity, inclusion and accessibility in scholarly publishing.
• PLS can diversify readership and authorship, address information inequity, include typically under-represented stakeholders and provide an accessible route into scholarly literature.

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Categorizations of the interface of evolution and religion     

Pear  Rachel S. A.  Malik  Shoaib Ahmed 《Cultural Studies of Science Education》2022,17(2):625-634

Cultural Studies of Science Education - This piece responds to the article by Arif Rachmatullah, Soonhye Park, and Minsu Ha “Crossing borders between science and religion: Muslim Indonesian...  相似文献   

India’s National Science Talent Search Examination (1963–1976)     

Philip  Rachel 《Science & Education》2022,31(1):241-263

Science & Education - India’s National Science Talent Search (NSTS) examination (1963 to 1976) was imagined and implemented by some top scientists of the period. It aimed to identify...  相似文献