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11.
Prasanthi Mannava Afshan Masood Ambika K. Devi 《Indian journal of clinical biochemistry : IJCB》2015,30(1):113-116
Albright hereditary osteodystrophy (AHO) is a rare hereditary metabolic disorder that may or may not be associated with resistance to parathyroid hormone (pseudohypoparathyroidism) or other hormones. The disorder is commonly characterized by a constellation of dysmorphic physical features and with biochemical levels that demonstrate hypocalcaemia and hyperphosphatemia. We report here a clinical case of a 14 year old male with AHO and we discuss his clinical features, radiographic and laboratory findings along with treatment. 相似文献
12.
Angom Ranjana Devi Mahuya Sengupta Dipu Mani Barman Yashmin Choudhury 《Indian journal of clinical biochemistry : IJCB》2021,36(3):296
Nicotine, responsible for the addictive properties of tobacco, is widely used in nicotine replacement therapy for tobacco use cessation. We investigated the time-dependent effect of treatment with nicotine on the tumor suppressor, DNA repair and immune responses. Swiss Albino mice (laca strain) of both sexes received nicotine dissolved at a dose of 100 µg/ml in 2% sucrose for 24 weeks, by oral gavage, while age- and gender-matched controls received only 2% sucrose for the same period. Nicotine-treated and control mice were sacrificed 6, 16 and 24 weeks post-treatment, and their tissues evaluated for alterations in histology, oxidative stress, TNF-α levels, nitric oxide (NO) and myeloperoxidase (MPO) release, tumor suppressor response and DNA repair response. Statistical significance of results was determined using Students’ t test. The tissues of nicotine treated mice exhibited a large number of multinucleated and binucleated cells, enlarged nuclei and non-uniform distribution of cells, significant increase in expression of TNF-α gene and serum TNF-α, and time-dependent significant increase in lipid peroxidation, protein carbonylation, NO and MPO release when compared to age-and gender-matched controls. The mRNA expression of the tumor suppressor gene p53, its primary regulator Mdm2, and the DNA repair genes Brca2 and Ape1 were significantly elevated, but the corresponding protein levels remained largely unaltered. In conclusion, treatment with nicotine caused oxidative stress and inflammation which can cause widespread cellular damage from the very onset of treatment, without subverting the tumor suppressor and DNA repair responses.Electronic supplementary materialThe online version of this article (10.1007/s12291-020-00903-8) contains supplementary material, which is available to authorized users. 相似文献
13.
Babarović Toni Dević Ivan Blažev Mirta 《International Journal for Educational and Vocational Guidance》2020,20(2):429-450
International Journal for Educational and Vocational Guidance - The study examines the effectiveness of a career intervention in middle schools. The intervention was organized in eight... 相似文献
14.
Sandhya Devi Coll Richard Kevin Coll 《Research in Science & Technological Education》2018,36(2):185-204
Background: Recent research and curriculum reforms have indicated the need for diversifying teaching approaches by drawing upon student interest and engagement in ways which makes learning science meaningful. Purpose: This study examines the integration of informal/free choice learning which occurred during learning experiences outside school (LEOS) with classroom learning using digital technologies. Specifically, the digital technologies comprised a learning management system (LMS), Moodle, which fits well with students’ lived experiences and their digital world. Design and Method: This study examines three out-of-school visits to Informal Science Institutes (ISI) using a digitally integrated fieldtrip inventory (DIFI) Model. Research questions were analysed using thematic approach emerging along with semi-structured interviews, before, during and after the visit, and assessing students’ learning experiences. Data comprised photographs, field notes, and unobtrusive observations of the classroom, wiki postings, student work books and teacher planning diaries. Results: We argue, that pre- and post-visit planning using the DIFI Model is more likely to engage learners, and the use of a digital learning platform was even more likely to encourage collaborative learning. The conclusion can also be drawn that students’ level of motivation for collaborative learning positively correlates with their improvement in academic achievement. 相似文献
15.
A very useful experiment of two dimensional potential mapping, namely electrolytic tank model, for graduate and post graduate
level physics students is given here. Laplace's equation is solved for the above and the results are compared with the experiment.
The agreement is so good that this is extended to complex problems. Monte Carlo simulation, an alternative to the above experiment,
is developed for these complex problems and compared with the experimental results of electrolytic tank model. 相似文献
16.
CH. V. Ramana Devi M. P. J. S. Anandaraj 《Indian journal of clinical biochemistry : IJCB》1994,9(1):21-23
The enhanced presence of calcium in the erythrocytes of thalassemia homozygotes along with an increase in cytosolic and membrane
bound CANP, and a decrease in membrane glycoprotein and total membrane sulfhydryl groups are statistically significant changes.In vitro loading of erythrocytes with calcium in the presence of lonophore A23187 caused similar changes pointing to the significance of calcium mediated proteolysis, especially by CANP in preparing erythrocytes
for the phagocytic event. 相似文献
17.
The present study was undertaken to investigate the relation of retinol with lipid profile of patients with cancers of breast,
stomach, oesophagus, colon, gallbladder, pancreas, lung and cervix. Serum retinol was assayed in 120 patients and 40 healthy
normal control by reverse phase HPLC using CLC-ODS C-18 columns and retinyl acetate as an internal standard.
Significant decease in serum cholesterol and LDL was observed in patients with cancers of esophagus, colon, stomach, pancreas
and gallbladder respectively.
Retinol was reduced in all forms of cancers but pronounced decrease was observed in oesophagus, gallbladder, pancreas, stomach
and colon. Serum Retinol in all patients was directly correlated with total cholesterol and LDL. These findings suggest that
therapeutic modalities of this vitamin could be planned for these patients, as vitamin A is known to act as an antioxidant
for prevention of certain cancers. 相似文献
18.
ABSTRACTIncreased school autonomy and a greater focus on achieving school effectiveness and improvement has made it essential to reconsider the role of school leaders (OECD 2009, Creating Effective Teaching and Learning Environments: First Results from TALIS. Paris: OECD Publishing). This recommends that leadership development in this rapidly changing world deserves significant consideration compared to the past. With the increasing interest entrusted to school leadership, this article reports on how school leaders are currently prepared by the higher education programmes offered in two out of three universities in Fiji. Through an extensive literature review as well as through programme documents and policy reviews, this article focuses on current educational leadership post-graduate courses offered at these Fijian universities and highlight areas of strengths as well as suggests recommendations for improvement that are in line with identified needs for effective principal preparation in a Fijian context with key connections made to the larger South Pacific region. 相似文献
19.
Chu Samuel K. W. Ravana Sri Devi Mok Sanny S. W. Chan Randolph C. H. 《Educational technology research and development : ETR & D》2019,67(4):881-906
Social technologies such as social networking sites, Wikis and blogs have gained popularity not only in social communication but also in other areas, such as in enhancing learning experience among students in tertiary education. This study investigated how blogs and Facebook scaffolded students’ learning during their internships in tertiary education. A mix-method approach was employed to examine students’ perceptions of blogs and Facebook in improving their internship learning experience. The results showed that blogs and Facebook encouraged students and facilitated their engagement in problem solving, information sharing and knowledge construction during their internships. In particular, Facebook showed more promising results, assisting students in reflecting on their experiences. Moreover, students acknowledged that Facebook was a better platform for online interaction and collaborative learning than blogs. This study provides empirical evidence for the use of social media tools in pedagogical scaffolding and collaborative learning during internships.
相似文献20.
Devi S. Drexler Dale F. Campbell 《Community College Journal of Research & Practice》2013,37(8):608-619
For decades, institutions of higher education have provided study abroad opportunities for college students wishing to increase and expand their intellectual and social skills. While many universities around the country have supported successful international exchange and study abroad programs, there is little research on community college study abroad programs and their impact on student development. Therefore, this article examines specific vectors that impact student development before and after study abroad participation in nine community colleges using Chickering's Theory of Student Development and SAS statistical methods. 相似文献