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Clinical proteomics encompasses the study of the proteins in the human body at different settings to understand the various physiological and pathological pathways. The processing of the samples for electrophoresis based proteomics is a challenge to any researcher. Salt in particular can have an array of effects during the electrophoretic separation of proteins. There is a definite need to determine the concentration of salts in the samples and the effectiveness of salt removing protocols on small volume samples. A simple-cost effective technique to know the salt concentration in the clinical proteomics samples has been highlighted in the report. The application will be of value in a developing country such as India.  相似文献   
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Hierarchical Text Categorization Using Neural Networks   总被引:8,自引:1,他引:7  
This paper presents the design and evaluation of a text categorization method based on the Hierarchical Mixture of Experts model. This model uses a divide and conquer principle to define smaller categorization problems based on a predefined hierarchical structure. The final classifier is a hierarchical array of neural networks. The method is evaluated using the UMLS Metathesaurus as the underlying hierarchical structure, and the OHSUMED test set of MEDLINE records. Comparisons with an optimized version of the traditional Rocchio's algorithm adapted for text categorization, as well as flat neural network classifiers are provided. The results show that the use of the hierarchical structure improves text categorization performance with respect to an equivalent flat model. The optimized Rocchio algorithm achieves a performance comparable with that of the hierarchical neural networks.  相似文献   
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Glycosylated Hemoglobin (GHb) was estimated using cation exchange resin binding method in 50 non diabetic healthy controls and 500 maturity onset diabetics. Percentage of glycosylated hemoglobin levels in controls was 7.27±0.456 (range 6.0–8.04) and 9.47±0.98 (range 8.2–13.63) in diabetic group. Glycosylated hemoglobin levels remain unaffected inspite of transient rise of serum glucose levels during an oral glucose tolerance test. Significantly elevated GHb A1. Furthermore significant elevation of GHb A1 was noticed in diabetics with all secondary complications suggesting poor glycemic control in these patients. The diabetics having retinopathy, nephropathy or diabetic foot had relatively higher GHb levels compared to patients having coronary artery disease or hypertension.  相似文献   
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Classics     
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Research exploring the means by which new media technologies can shape development within marginalized communities worldwide has began to move away from discussion limited to technical and infrastructural, to consider the interactions, beliefs, and values of local communities. Yet most projects continue to focus on enabling communities to access external information, rather than on the possibility of using media to catalyze community reflection and thereby developmental activity from within. This article shows how this promise can be actualized by providing an overview of an experimental project that made available a set of video cameras to a carefully selected group of community members in a ritualized, largely nonliterate village in Andhra Pradesh, India. It concludes that policymakers, researchers, and practitioners would benefit from considering the possibilities that reflective media hold to generate collective action and consensus building, and that these possibilities can synergize with the need to develop scalable projects.  相似文献   
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Simple models for deterministic systems are explained in this part. These models are useful in engineering, business, economics and sociology.  相似文献   
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