Interleukin-6 Perpetrator of the COVID-19 Cytokine Storm     

Jyoti Shekhawat  Kavya Gauba  Shruti Gupta  Purvi Purohit  Prasenjit Mitra  Mahendra Garg  Sanjeev Misra  Praveen Sharma  Mithu Banerjee 《Indian journal of clinical biochemistry : IJCB》2021,36(4):440

COVID-19 has emerged as a global pandemic. It is mainly manifested as pneumonia which may deteriorate into severe respiratory failure. The major hallmark of the disease is the systemic inflammatory immune response characterized by Cytokine Storm (CS). CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Of these, IL-6 is found to be significantly associated with higher mortality. IL-6 is also a robust marker for predicting disease prognosis and deterioration of clinical profile. In this review, the pivotal role played by IL-6 in the immuno-pathology of COVID-19 has been illustrated. The role of IL-6 as a pleiotropic cytokine executing both pro and anti-inflammatory activities has been reviewed. ADAM 10, a metalloproteinase switches the anti-inflammatory pathway of IL-6 to pro inflammatory hence blocking the action of ADAM 10 could be a new therapeutic strategy to mitigate the proinflammatory action of IL-6. Furthermore, we explore the role of anti-IL6 agents, IL-6 receptor antibodies which were being used for autoimmune diseases but now are being repurposed for the therapy of COVID-19.  相似文献   

Current status of the lateral flow immunoassay for the detection of SARS-CoV-2 in nasopharyngeal swabs     

Anita Somborac Ba ura  Marija Doroti&#x;  Leonarda Gro&#x;i&#x;  Monika Dimbeg  Slavica Dodig 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(2)

Early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diagnosis of coronavirus disease 2019 (COVID-19) are priorities during the pandemic. Symptomatic and suspected asymptomatic individuals should be tested for COVID-19 to confirm infection and to be excluded from social interactions. As molecular testing capacity is overloaded during the pandemic, rapid antigen tests, such as lateral flow immunoassays (LFIAs), can be a useful tool as they allow greater test availability and obtain results in a very short time. This short review aims to present the analytical properties of LFIAs in the detection of SARS-CoV-2 in nasopharyngeal swabs. Lateral flow immunoassay is a method that combines thin-layer chromatography and indirect immunochemical sandwich method and allows the detection of a specific SARS-CoV-2 antigen in nasopharyngeal swabs. Swab specimens should be adequately collected and tested as soon as possible. Users should pay attention to quality control and possible interferences. Antigen tests for SARS-CoV-2 show high sensitivity and specificity in cases with high viral loads, and should be used up to five days after the onset of the first symptoms of COVID-19. False positive results may be obtained when screening large populations with a low prevalence of COVID-19 infection, while false negative results may happen due to improper specimen collection or insufficient amount of antigen in the specimen. So as to achieve reliable results, a diagnostic accuracy study of a specific rapid antigen test should be performed.  相似文献   

Doctoral students’ experiences of nondisclosure with their dissertation chair     

Ryan M. Cook  Rachel Crabtree  Corrine R. Sackett  Andrea Baylin  Jyotsana Sharma 《Counselor Education & Supervision》2023,62(1):64-79

We examined doctoral students’ experiences of nondisclosure with their dissertation chairs. Using a hermeneutic phenomenology design, we analyzed two individual interviews of 10 doctoral students. We identified the following three themes: (a) the professional dynamics in the relationship, (b) the interpersonal and cultural dynamics in the relationship, and (c) prioritization of completing the dissertation. Implications for doctoral students and dissertation chairs are discussed.  相似文献   

The Role of Relational and Instructional Classroom Supports in the Language Development of At-Risk Preschoolers     

Carolyn S. Gosse  Anita S. McGinty  Andrew J. Mashburn  LaVae M. Hoffman  Robert C. Pianta 《Early education and development》2014,25(1):110-133

The present study examined the extent to which preschool classroom supports—relational support (RS) and instructional support (IS)—are associated with children's language development and whether these associations vary as a function of children's language ability. The language skills of 360 children within 95 classrooms were assessed using an expressive narrative task in the fall and spring of the preschool year, teachers rated RS in the fall, and observations of IS were collected across the year. Research Findings: Hierarchical linear models revealed main effects of IS, but not RS, on preschoolers’ development of expressive language skills. In addition, the associations between RS and IS on children's expressive language development were moderated by children's fall language ability. Specifically, the association between IS and language development was stronger for children with stronger expressive language skills, and the association between RS and language development was stronger for children with weaker expressive language skills. Practice or Policy: These findings suggest that professional development for preschool teachers might focus on aligning classroom supports with the needs of children with weaker language skills who are at risk for difficulty acquiring literacy.  相似文献   

A system-wide professional learning approach about inclusion for teachers in Hong Kong     

Chris Forlin  Tim Loreman  Umesh Sharma 《Asia-Pacific Journal of Teacher Education》2014,42(3):247-260

This study examines changes in attitudes, teaching efficacy, and concerns about inclusive education in a sample of 2361 teachers in Hong Kong who took a professional learning course about inclusive education. Participants completed a questionnaire seeking demographic information and their perceptions about these three aspects of inclusive education both before and after their course. Items were selected from the Sentiments, Attitudes, and Concerns about Inclusive Education Scale Revised and Teacher Efficacy for Inclusive Practices scales that were of relevance to the objectives of this study. The results indicate that in all three areas of acceptance, teaching efficacy, and concerns about inclusive education, positive improvements were made as a result of training, although generally this improvement was strongest in areas that teachers felt were under their direct control. The small amount of change in areas that teachers felt were not under their control may indicate that whatever change initiatives are put in place, they need to be holistic and systemic.  相似文献   

Negotiating spaces: the in-betweeness of becoming a teacher     

Anita Sinner 《Asia-Pacific Journal of Teacher Education》2010,38(1):23-37

Pre-service teachers move through multiple learning communities during teacher education programs, arguably emerging as authentic insiders in teaching culture. In this case study, a critical perspective is offered by Ann, a First Nations learner who described her experience of teacher education, and how she came to question different aspects of her university program and practicum assignment which challenged her understandings of self. The experiences of pre-service teachers like Ann are often hidden from view, and what they perceive as shortcomings in programming are often unseen within institutional contexts. Ann articulated numerous gaps that still reside within teacher culture despite structures that are in place to address such gaps. The situated knowledge of pre-service teachers can offer alternative perspectives to guide the future of teacher education by drawing attention to shifts underway among students that will change the nature of professional practice.  相似文献   

Screening of field pea （Pisum sativum） selections for their reactions to root-knot nematode （Meloidogyne incognita）     

Sharma A  Haseeb A  Abuzar S 《Journal of Zhejiang University. Science. B》2006,7(3):209-214

INTRODUCTION Fieldpea (Pisum sativum L.) is one of the im-portant pulse crops of the world and is cultivated over 5.9 million hectares with a production of about 11.7 million tons (Singh, 1983). In India it is grown over 0.7 million hectares yielding about 0.6 million tons (Singh, 1983). Among various obstacles in cultivating this crop, root-knot nematode Meloidogyne incognita (Kofoid & White) Chitwood has been reported to cause severe yield losses of up to 20%~33% (Upadhyay and Dwiv…  相似文献   

Near,Far, Wherever You Are: Chemistry via Distance in the South Seas     

Shaneel Chandra  Bibhya Sharma 《The American journal of distance education》2018,32(2):80-95

The University of the South Pacific is owned by 12 nations in the South Pacific Ocean. The institution provides higher education through its 14 campuses, with at least 1 campus per member country. To be able to overcome the geographical divide and isolation, while ensuring high-quality learning and teaching, the university utilizes Internet, satellite, and mobile devices and other Information and Communications Technology (ICT) tools and technologies to provide virtual classroom experience. This article outlines the approaches adopted in offering a first-year chemistry course, in parallel, through face-to-face and distance modes. The novel attributes of bridging the geographical divide are presented. The article concludes with a discussion of new innovations that will further bring the classroom to the student irrespective of where the student is in the world.  相似文献   

Self-Assembly of Colloidal Particles     

Prerna Sharma 《Resonance》2018,23(3):263-275

Colloidal dispersions are suspensions of micron-sized solid particles in a solvent like water or oil. Self-assembly is a widely used approach to create ordered structures of colloidal particles by engineering the inter-colloid potential. This article illustrates how entropy drives disorder to order transitions in a colloidal assembly.  相似文献   

Lead: Tiny but Mighty Poison     

Chaffy Sachdeva  Kshema Thakur  Aditi Sharma  Krishan Kumar Sharma 《Indian journal of clinical biochemistry : IJCB》2018,33(2):132-146

The documentation of lead toxicity (plumbism) dates back to the times when man learnt its various applications. This versatile heavy metal is non-degradable and its ability to get accumulated in the body that goes undiagnosed, makes it a serious environmental health hazard. Lead is now known to affect almost every organ/tissue of the human body. With irreversible effects on neurobiological development of young children and foetus, its toxicity has lasting implications on the human life. Outlining the symptoms, diagnosis and treatment therapy for lead poisoning, the present review elaborates the pathophysiological effects of lead on various organs. This will be of immense help to the health professionals so as to inculcate a better understanding of the lead poisoning which otherwise is asymptomatic. With chelation therapy being the classic path of treatment, new strategies are being explored as additive/adjunct therapy. It is now understood that lead toxicity is completely preventable. In this regard significant efforts are in place in the developed countries whereas much needs to be done in the developing countries. Spreading the awareness amongst the masses by educating them and reducing the usage of lead following stricter industry norms appears to be the only roadmap to prevent lead poisoning. Efforts being undertaken by the Government of India and other organisations are also mentioned.  相似文献