Purification and Characterization of an Endoinulinase from Xanthomonas campestris pv. phaseoli KM 24 Mutant     

Kameshnee Naidoo  Ajit Kumar  Vikas Sharma  Kugen Permaul  Suren Singh 《Food Technology and Biotechnology》2015,53(2):146-153

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Impact of Chronic Lead Exposure on Selected Biological Markers   总被引：1，自引：0，他引：1  

Ambica P. Jangid  P. J. John  D. Yadav  Sandhya Mishra  Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2012,27(1):83-89

Lead poisoning remains a major problem in India due to the lack of awareness of its ill effects among the clinical community. Blood lead, δ-aminolevulinic acid dehydratase (δ-ALAD) and zinc protoporphyrin (ZPP) concentrations are widely used as biomarkers for lead toxicity The present study was designed to determine the impact of chronic lead exposure on selected biological markers. A total of 250 subjects, of both sexes, ranging in age from 20 to 70 years, were recruited. On the basis of BLLs, the subjects were categorized into four groups: Group A (BLL: 0–10 μg/dl), Group B (BLL: 10–20 μg/dl). Group C (BLL: 20–30 μg/dl) and Group D (BLL: 30–40 μg/dl) having BLLs of 3.60 ± 2.71 μg/dl, 15.21 ± 2.65 μg/dl, 26.82 ± 2.53 μg/dl and 36.38 ± 2.83 μg/dl, respectively. Significant changes in biological markers due to elevated BLLs were noted. The relation of BLL and biological markers to demographic characteristics such as sex, habits, diet and substances abuse (smoking effect) were also studied in the present investigation. Males, urban population, non-vegetarians, and smokers had higher blood lead levels. δ-ALAD activity was found to be significantly lower with increased BLL (P < 0.001), while the ZPP level was significantly higher with increased BLL (P < 0.001). Further, BLL showed a negative correlation with δ-ALAD (r = −0.425, P < 0.001, N = 250) and a positive correlations with ZPP (r = 0.669, P < 0.001, N = 250). Chronic lead exposure affects the prooxidant-antioxidant equilibrium leading to cellular oxidative stress.  相似文献   

Vanishing species: The planet in crisis     

Uttam Saikia  Narayan Sharma  Abhijit Das 《Resonance》2010,15(4):321-336

Rapid extinction of species is one of the most serious ecological problems faced by humanity today. Species are disappearing at a pace unprecedented in the history of the planet putting the very future of life at risk. The irony is that the root of the crisis is another species, Homo sapiens rather than some physical events that is poised to threaten its own survival. This article gives a brief introduction to the crisis, its consequences and possible mitigation strategies.  相似文献   

The impact of chronic carbohydrate manipulation on mucosal immunity in elite endurance athletes     

Alannah K. A. McKay  David B. Pyne  Peter Peeling  Avish P. Sharma  Megan L.R. Ross  Louise M. Burke 《Journal of sports sciences》2019,37(5):553-559

Carbohydrate (CHO) availability could alter mucosal immune responses to exercise. This study compared the effect of three dietary approaches to CHO availability on resting and post-exercise s-IgA levels. Elite race walkers (n = 26) adhered to a high CHO diet (HCHO), periodised CHO availability (PCHO) or a low CHO/high fat diet (LCHF) for 3 weeks while completing an intensified training program. HCHO and PCHO groups consumed 8.0–8.5 g.kg^?1 CHO daily, with timing of ingestion manipulated to alter CHO availability around key training sessions. The LCHF diet comprised 80% fat and restricted CHO to < 50 g.day^?1. A race walk test protocol (19 km females, 25 km males) was completed at baseline, after adaptation, and following CHO restoration. On each occasion, saliva samples were obtained pre- and post-exercise to quantify s-IgA levels. Resting s-IgA secretion rate substantially increased ~ two-fold post-intervention in all groups (HCHO: 2.2 ± 2.2, PCHO: 2.8 ± 3.2, LCHF: 1.6 ± 1.6; fold-change± 95% confidence limits), however, no substantial differences between dietary treatments were evident. Post-exercise, substantial 20–130% increases in s-IgA concentration and 43–64% reductions in flow rate occurred in all dietary treatments, with trivial differences evident between groups. It appears that high volume training overrides any effect of manipulating CHO availability on mucosal immunity in elite athletes.  相似文献   

Inherited Memories     

Vanita Sharma 《Cultural and Social History》2013,10(4):411-428

ABSTRACT

This article explores the creation and transmission of second generation memories concerning the 1947 Partition of British India. The research is based on oral interviews with Punjabi families who migrated because of Partition and now live in Lahore and Delhi. It explores how Partition memories have been transmitted across generations within these families, and also examines similarities and differences between how the second generation interviewees from Delhi and Lahore remember Partition. It demonstrates that the second generation have not passively accepted everything that the first generation, or the state, has told them about Partition. The second generation's memories are also shaped by their age, nationality, religion and class, and the nature of contemporary politics.  相似文献   

Molecular Basis of Cystic Fibrosis Disease: An Indian Perspective     

Prasad R  Sharma H  Kaur G 《Indian journal of clinical biochemistry : IJCB》2010,25(4):335-341

Cystic fibrosis is a common autosomal recessive disorder usually found in population of white Caucasian descent. Now it is well documented the presence of CF disease in India with the advancement of laboratory testing. As once it was thought non existence of this disease in our population. Most of the phenotype of CF disease was in accordance of western population. Genetic analysis of CFTR gene in Indian CF patients revealed that most common mutation was delta F508 mutation. However, it was less than Caucasian population. CFTR mutations are also a causative factor in the pathogenesis of male infertility due to obstructive azoospermia. There are two most common mutation viz. IVS8-T5 and delta F508 which are responsible for congenital absence of vas deferens in male infertility patients. Elevated levels of sweat chloride at two occasions along with the presence of two mutations in CFTR gene was gold standard method for diagnosis of CF disease. It is noteworthy here that due to magnitude of Indian population, the total CF disease load would be more than many European countries. Clinical data demonstrate the prevalence of both classical and genetic form of CF in India.  相似文献   

To study the effect of diet supplementation with coconut oil, mustard oil and sunflower oil on blood lipids in rabbit     

Soni ND  Choudhary U  Sharma P  Dube A 《Indian journal of clinical biochemistry : IJCB》2010,25(4):441-442

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Tumor necrosis factor alpha (TNF-α) and estrogen hormone in osteoarthritic female patients     

Pradeep Sharma  Neelima Singh  Vinod Singh  Sanjeev Singh  Harsh vardhan Singh  Sameer Gupta 《Indian journal of clinical biochemistry : IJCB》2006,21(1):205-207

Osteoarthritis of knee joints is a disease of old age in both sex. It is very common after the age of 40 years in elderly females or in postmenopausal phase of females. It is characterized by narrowing of space in joints due to inflammation. The exact mechanism of inflammation in this disease is not yet clear. Tumor necrosis factor alpha (TNF-α) may involve in onset of disease. The present study is being carried out in 130 female subject of age group 40–60 years suffering from osteoarthritis of knee joints and 50 normal healthy control female subjects. A correlation is made between TNF-α and estrogen and found significant inverse correlation (r<0.001), between TNF-α and estrogen hormone in osteoarthritic female patients as compared to normal healthy control female group.  相似文献   

Understanding teachers’ concerns about inclusive education     

Monika Yadav  Ajay Das  Sushama Sharma  Ashwini Tiwari 《Asia Pacific Education Review》2015,16(4):653-662

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Assessing the Relationship Between Prosody and Reading Outcomes in Children Using the PEPS-C     

Margaret Lochrin  Joanne Arciuli  Mridula Sharma 《Scientific Studies of Reading》2015,19(1):72-85

This study investigated the relationship between both receptive and expressive prosody and each of three reading outcomes: accuracy of reading aloud words, accuracy of reading aloud nonwords, and comprehension. Participants were 63 children aged 7 to 12 years. To assess prosody, we used the Profiling Elements of Prosody in Speech Communication (PEPS-C; Peppé & McCann, 2003). Results revealed that certain subtests of the PEPS-C predicted a substantial proportion of variance across reading outcomes, even after age and segmental phonological awareness have been considered. In fact, our findings suggest that the PEPS-C compares favourably with a well-established test of segmental phonological awareness, the Comprehensive Test of Phonological Processing (CTOPP; Wagner, Torgesen, & Rashotte, 1999), in terms of its power to predict variability in children’s reading.  相似文献