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Self‐paced segmentation of written words on a touchscreen tablet promotes the oral production of nonverbal and minimally verbal children with autism 
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下载免费PDF全文 Frédérique Vernay Harma Kahina Marrone Thierry Roussey Jean‐Yves 《Journal of Research in Special Educational Needs》2017,17(4):265-273
We investigated in a pilot study the effects of various types of visual mediation (photos, written words and self‐paced syllabic segmentation of written words displayed on a touchscreen tablet) that are thought to facilitate the oral production of nonverbal and minimally verbal children with autism, according to the participants’ level of oral language development and, more specifically, their ability to produce delayed echolalia. We also sought to identify the cognitive characteristics that need to be taken into account when seeking to develop the oral production of nonverbal children with autism. Results showed that the nonverbal and minimally verbal children with autism were able of using written words to produce them orally. Their performance was largely dependent on their level of language development. Tasks combining written and oral modalities prompted some of them to engage in oral production for the first time (isolated syllables for nonverbal children) and allowed others to produce non‐random strings of syllables (minimally verbal children). 相似文献
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Building on recent breakthroughs in the field of microfluidic-based capture of rare cancer cells circulating in the blood, the present article reports on the use of Herceptin functionalized PDMS devices designed to efficiently capture from blood cancer cells, overexpressing the tyrosine kinase human epidermal growth factor receptor (HER2). The identification of patients overexpressing HER2 is critical as it typically associates with an aggressive disease course in breast cancer and poor prognosis. Importantly, HER2 positive patients have been found to significantly benefit from Herceptin (Trastuzumab), a humanized monoclonal antibody (MAb) against HER2. Disposable PDMS devices prepared using standard soft lithography were functionalized by the plasma polymerization of an epoxy-containing monomer. The epoxy-rich thin film (AGEpp) thus created could be conjugated with Herceptin either directly or through a polyethylene glycol interlayer. The properties and reactivity toward the monoclonal antibody conjugation of these coatings were determined using x-ray photoelectron spectroscopy; direct conjugation provided a good compromise in reactivity and resistance to biologically nonspecific fouling and was selected. Using the breast cancer cell line SK-BR-3 as a model for cells overexpressing HER2, the immunocapture efficacy of the Herceptin functionalized PDMS was demonstrated in model studies. Validation studies confirmed the ability of the device to efficiently capture (～80% capture yield) HER2 positive cells from full blood. 相似文献
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During the Paris Olympic Games of July 1924, there were a series of ‘incidents’ in the fencing competition that became known as the Puliti affair. At the centre of the troubles was the Italian Oreste Puliti. The ‘affair’ had to be discussed by the ‘jury d'honneur’ recently set up by the IOC. Both the IOC and the International Federation were concerned with this issue for four more years. This article uses the Puliti affair to discuss several aspects of nationalism in the mid-1920s: the growing tensions between Fascist Italy and democracies such as Hungary and France, the specific Olympic status of fencing challenged in Paris after three centuries of confrontation between the French and Italian schools of fencing, and ongoing tensions between the IOC and the international federations. Finally, the press perceptions of the incident in various countries are briefly discussed. 相似文献
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Thierry Ozwald 《Sport in History》2019,39(3):334-349
ABSTRACT‘It is a sport’ writes Hemingway on the subject of bullfights in public places, ‘a very wild and primitive sport and, mainly, a true sport of amateurs. I fear however that because of danger of death which it implies, it never has great success among the sporting-men of America and England’ (Death in the afternoon, Gallimard, 1938, p. 27). Hemingway was interested in sport since his young age: athletic, a follower of sports at Oak Park's High School, fascinated by horse racing and later an enthusiast for deep sea fishing, hunting, boxing etc, in other words what we would call today the ‘extreme sports’, he had a passion for bullfighting in Spain, which he tested, although unsuccessfully. In his papers for the Toronto Weekly Star, his novel The Sun also rises published in 1926, and especially in his essay Death in the afternoon, a true treaty of bullfighting, he undertakes a close study of the specific techniques of this very particular sport; yet what interests him most of all is its artistic value. Art or sport? Such is the key question that he poses throughout the pages of this work, which are actually a deep reflection on the origins of the sport and the finality of art; the relations between sport and art are quite complex and, according to him, have to be reconsidered, since writing for him is also linked to moral and physical effort, and is even a kind of ‘intimate bullfighting’. 相似文献
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The aim of this study was to assess responses to taper in elite athletes using computer simulations. Parameters of a non-linear model were derived from training and performance data over two seasons for eight elite swimmers. The fit between modelled and actual performances was statistically significant for each swimmer (r(2) = 0.56 +/- 0.06; P < 0.01). The simulations were used to estimate characteristics of step and progressive tapers that would maximize performance either (1) after regular training only or (2) after overload training of a 20% step increase in regular training for 28 days. The highest performance with a step taper was greater with than without prior overload training (101.4%, s = 1.6 vs. 101.1%, s = 1.4 of personal record; P < 0.01) but required a longer taper duration (22.4 days, s = 13.4 vs. 16.4 days, s = 10.3; P < 0.05). The optimal progressive taper led to a better performance only after the overload period (101.5%, s = 1.5; P < 0.001). Negative and positive influences of training were estimated as indicators of fatigue and adaptations to training respectively. During the optimal taper, the negative influence was completely removed, independently of the prior training, whereas the positive influence increased only after overload training. Our computer simulations show that the characteristics of an optimal training reduction in elite athletes depend on the training performed in the weeks prior to a taper. 相似文献
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Jean-Marc Giannoli Stphanie Albarede Thierry Avellan Jean-Pierre Bouilloux Rgine Cartier Richard Cohen Nathalie Colard Luc Essemilaire Jean-Louis Galinier Mathieu Kuentz Mickaël Paris Henri Portugal Florian Scherrer Jean-Pascal Siest Anne Vassault Jean-Michel Vialle 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(2)
This is a translation of the paper “Recommendations for the application and follow-up of quality controls in medical biology laboratories” published in French in the journal Annales de Biologie Clinique (Recommandations pour la mise en place et le suivi des contrôles de qualité dans les laboratoires de biologie médicale. Ann Biol Clin (Paris). 2019;77:577-97.). The recommendations proposed in this document are the result of work conducted jointly by the Network of Accredited Medical Laboratories (LABAC), the French Society of Medical Biology (SFBC) and the Federation of Associations for External Quality Assessment (FAEEQ). The different steps of the implementation of quality controls, based on a risk analysis, are described. The changes of reagent or internal quality control (IQC) materials batches, the action to be taken in case of non-conform IQC results, the choice of external quality assessment (EQA) scheme and interpretation of their results as well as the new issue of analyses performed on several automatic systems available in the same laboratory are discussed. Finally, the concept of measurement uncertainty, the robustness of the methods as well as the specificities of near-patient testing and rapid tests are described. These recommendations cannot apply for all cases we can find in medical laboratories. The implementation of an objective alternative strategy, supported with documented evidence, might be equally considered. 相似文献
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The violence and duration of fighting throughout the Great War created an intense feeling of vulnerability among the men engaged in battle, which challenged their perception of manliness. When the Americans joined the war in 1917, the balance between the two opposing armies was modified and the psychological crises of French soldiers brought to an end. The confidence shown by the American soldiers and their first successes on the battlefield changed the way the French Poilus perceived their new allies. From scepticism to admiration, Frenchmen's feelings extended beyond the fighting. Indeed, by living with American soldiers in the trenches and camps behind the front, French soldiers discovered a new culture where games and sport played a major role and contributed to building manliness. The Foyers Franco-Americains du Soldat (Franco-American hostels for soldiers) provided an ideal place for the cultural transfer of a model of masculinity from Sammys to Poilus. The foyers were managed by the American YMCA and eventually reached the number of 1,500 in France during the war. These hostels afforded soldiers numerous opportunities to develop cultural and sports practices, by bringing together Americans and Frenchmen. Mainly based on the archives of the American Expeditionary Forces, the YMCA and the French Army, the paper argues that the Foyers du Soldat brought to light a new model of masculinity based on sport, which challenged the Frenchmen's vision. It aims to show the rapid transformation of masculine identity within a context of extreme vulnerability and confirms the changes in representations of men in French society at this time. 相似文献
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Thierry Olive Monik Favart Caroline Beauvais Lucie Beauvais 《Learning and Instruction》2009,19(4):299-308
This study investigated the cognitive effort of 5th and 9th graders while writing a text. We manipulated genre (narrative text vs. argumentative text) and tested how level of handwriting automatisation contributes to cognitive effort and fluency in writing. The participants were 23 students from Grade 5 and 21 from Grade 9, who wrote two texts differing in genre while performing a secondary reaction time task. The results showed that cognitive effort interacted with genre. Cognitive effort decreased between Grades 5 and 9 only for writing argumentative text. Handwriting did not contribute to fluency in writing, but contributed to cognitive effort only in 5th-graders' writing of narrative text. The findings are discussed in light of the factors contributing to cognitive effort and fluency in writing. 相似文献