Book reviews     

Alexander Vucinich  Edward J. Monahan  Bernard D. Davis  Arthur Hearnden  Paolo Palladino  Bruce L. R. Smith 《Minerva》1991,29(4):476-516

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Prevention of child abuse and neglect through early diagnosis of serious disturbances in the mother-child relationship in Italy     

Ernesto Caffo  Gian Paolo Guaraldi  Giorgio Magnani  Rita Tassi 《Child abuse & neglect》1982,6(4):453-463

At the obstetrical clinic of Modena University and a family center of the same municipality during the first six months of 1980 a questionnaire based on "Risks of Child Abuse" by Kempe, Gray and others was administered to 33 expectant mothers during the third trimester of pregnancy, a few days after delivery, and a month and one-half after childbirth, for the purpose of examining the mother-child relationship. Two principal groups of "risk factors" which may lead to child abuse and neglect appeared: mothers with preceding personal and social experiences, and cases of medical intervention (e.g., prematurity, caesarean). Use of a questionnaire that permitted early diagnosis made possible help in establishing a good mother-child relationship in the first months of life. Such help can be given by the hospital and public centers both before and after birth.  相似文献   

Beyond contact-tracing: The public value of eHealth application in a pandemic     

Paolo Gerli  Emmanuel Ogiemwonyi Arakpogun  Ziad Elsahn  Femi Olan  Karla Simone Prime 《Government Information Quarterly》2021,38(3):101581

This study adopts a public value perspective to examine the eHealth services deployed by national and regional governments to contain the coronavirus (Covid-19) pandemic, including symptoms checkers, information portals and contact-tracing applications. We analyse 50 cases of eHealth applications adopted in 25 European Economic Area (EEA) and outline how these systems and technologies map against four dimensions of public value: user orientation, participation, legality and equity. Our findings reveal that the public value of the eHealth applications adopted in the context of the current pandemic is affected by both endogenous and exogenous factors that undermine their ability to improve the quality of healthcare services and social wellbeing. We conclude by suggesting areas for further research to address such factors and the trade-offs emerging between different dimensions of public value.  相似文献   

Comparison of Freelite and N-Latex serum free light chain assays: a critical review     

Massimo Daves  Andrea Piccin  Vincenzo Roccaforte  Giuseppe Lippi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)

IntroductionThe measurement of serum free light chain (FLC) represents a fundamental aspect on the assessment of patients with monoclonal gammopathies (MG). Different analytical methods for FLC have become available with the possibility to obtain different value with a substantial impact on the assessment of patients with MG. This study aimed to evaluate FLC results obtained with two different assays and how the difference value obtained can impact in the patient’s assessment.Materials and methodsNinety-three patient serum samples that underwent analysis for FLC with two different methods, Serum Freelite (The Binding Site, Birmingham, UK) and N-Latex FLC (Siemens, Marburg, Germany), were included in this retrospective study. Statistical analysis was performed to evaluate correlation, difference, and the grade of concordance between the results obtained with the two methods.ResultsSignificant statistical differences between the results obtained from the two methods were found (P < 0.05). A good correlation was found (0.99 for κ FLC, 0.95 for λ FLC, and 0.94 for the κ/λ ratio, respectively). We found a weighted kappa value of 0.65 for κ/λ ratio, 0.65 for λ FLC and 0.90 for κ FLC. A positive bias found with the Bland-Altman plot mirrors overestimation of κ FLC and κ/λ ratio with Freelite compared to N-Latex, whilst a negative bias underscores underestimation of λ FLC by Freelite compared to N-Latex.ConclusionAlthough in general the concordance between Freelite and N-Latex appears satisfactory, several discrepancies could be evidenced and consequently the two assays are not interchangeable.  相似文献   

Implementation of Web 2.0 services in academic, medical and research libraries: a scoping review     

Gardois P  Colombi N  Grillo G  Villanacci MC 《Health information and libraries journal》2012,29(2):90-109

Background: Academic, medical and research libraries frequently implement Web 2.0 services for users. Several reports notwithstanding, characteristics and effectiveness of services are unclear. Objectives: To find out: the Web 2.0 services implemented by medical, academic and research libraries; study designs, measures and types of data used in included articles to evaluate effectiveness; whether the identified body of literature is amenable to a systematic review of results. Methods: Scoping review mapping the literature on the topic. Searches were performed in 19 databases. Inclusion criteria: research articles in English, Italian, German, French and Spanish (publication date ≥2006) about Web 2.0 services for final users implemented by academic, medical and research libraries. Reviewers’ agreement was measured by Cohen’s kappa. From a data set of 6461 articles, 255 (4%) were coded and analysed. Results: Conferencing/chat/instant messaging, blogging, podcasts, social networking, wikis and aggregators were frequently examined. Services were mainly targeted at general academic users of English‐speaking countries. Conclusions: Data prohibit a reliable estimate of the relative frequency of implemented Web 2.0 services. Case studies were the prevalent design. Most articles evaluated different outcomes using diverse assessment methodologies. A systematic review is recommended to assess the effectiveness of such services.  相似文献   

Microliter-bioreactor array with buoyancy-driven stirring for human hematopoietic stem cell culture     

Camilla Luni  Hope C. Feldman  Michela Pozzobon  Paolo De Coppi  Carl D. Meinhart    Nicola Elvassore 《Biomicrofluidics》2010,4(3)

This work presents the development of an array of bioreactors where finely controlled stirring is provided at the microliter scale (100–300 μl). The microliter-bioreactor array is useful for performing protocol optimization in up to 96 parallel experiments of hematopoietic stem cell (HSC) cultures. Exploring a wide range of experimental conditions at the microliter scale minimizes cost and labor. Once the cell culture protocol is optimized, it can be applied to large-scale bioreactors for stem cell production at the clinical level. The controlled stirring inside the wells of a standard 96-well plate is provided by buoyancy-driven thermoconvection. The temperature and velocity fields within the culture volume are determined with numerical simulations. The numerical results are verified with experimental velocity measurements using microparticle image velocimetry (μPIV) and are used to define feasible experimental conditions for stem cell cultures. To test the bioreactor array’s functionality, human umbilical cord blood-derived CD34⁺ cells were cultured for 7 days at five different stirring conditions (0.24–0.58 μm∕s) in six repeated experiments. Cells were characterized in terms of proliferation, and flow cytometry measurements of viability and CD34 expression. The microliter-bioreactor array demonstrates its ability to support HSC cultures under stirred conditions without adversely affecting the cell behavior. Because of the highly controlled operative conditions, it can be used to explore culture conditions where the mass transport of endogenous and exogenous growth factors is selectively enhanced, and cell suspension provided. While the bioreactor array was developed for culturing HSCs, its application can be extended to other cell types.  相似文献   

What is the future of electrical impedance spectroscopy in flow cytometry?     

Furkan Gke  Paolo S. Ravaynia  Mario M. Modena  Andreas Hierlemann 《Biomicrofluidics》2021,15(6)

More than 20 years ago, electrical impedance spectroscopy (EIS) was proposed as a potential characterization method for flow cytometry. As the setup is comparably simple and the method is label-free, EIS has attracted considerable interest from the research community as a potential alternative to standard optical methods, such as fluorescence-activated cell sorting (FACS). However, until today, FACS remains by and large the laboratory standard with highly developed capabilities and broad use in research and clinical settings. Nevertheless, can EIS still provide a complement or alternative to FACS in specific applications? In this Perspective, we will give an overview of the current state of the art of EIS in terms of technologies and capabilities. We will then describe recent advances in EIS-based flow cytometry, compare the performance to that of FACS methods, and discuss potential prospects of EIS in flow cytometry.  相似文献   

Study of silica nanoparticles – polysiloxane hydrophobic treatments for stone-based monument protection     

Lavinia de Ferri  Pier Paolo Lottici  Andrea Lorenzi  Angelo Montenero  Emma Salvioli-Mariani 《Journal of Cultural Heritage》2011,12(4):356

The growing interest in the conservation of historic buildings encourages the development of water-repellent materials and methodologies to consolidate and/or protect stones. Recently, particular attention was devoted to composites of inorganic oxides nanoparticles and hybrid siloxane or silicone polymers. Here we present a study on the water repellence of a thin protective coating obtained through sol-gel process starting from Glymo and Dynasylan 40®, and loading the silicate matrix with nano-sized silica particles (Aeroxide LE1® -Degussa-Evonik). The coatings were applied to limestone, sandstone and granite samples. The silica nanoparticles have been characterized by XRD, the siloxane matrix through micro-Raman spectroscopy, while the surface morphology was examined by SEM. The efficacy of the treatments has been evaluated through static contact angle measurements and capillary water absorption. The optical appearance of the coatings was evaluated by colorimetric measurements. Nanoparticles at suitable concentration gave high values for the static contact angle (up to ∼ 150°), for all stone species even for four months exposure to atmospheric conditions. The coatings, in the water capillary absorption tests, however, behave as expected only for granite even if the long-term water direct contact reduces the hydrophobicity.  相似文献   

A structural equation model predicting adults’ online learning self-efficacy     

Calaguas  Noriel P.  Consunji  Paolo Maria P. 《Education and Information Technologies》2022,27(5):6233-6249

Education and Information Technologies - We aimed to model the direct effects of the theorized relationships of academic self-efficacy, computer use self-efficacy, learning management system...  相似文献   

Kuhn’s normal scholarship     

Politi  Vincenzo 《Metascience》2022,31(2):231-234

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