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21.
Siew Ming Thang 《Open Learning》2013,28(3):243-256
The paper describes a study that investigated Malaysian distance learners’ perceptions of their English proficiency courses. The approach used in this study was primarily a quantitative approach based on questionnaires, with a qualitative component based on semi‐structured interviews included to add depth and scope to the study. The questionnaires used were adapted from Entwistle and Ramsden’s Course Perception Questionnaire. ANOVA and factor analysis were used for analysing the questionnaire data. The interview data were analysed qualitatively by identifying main themes and patterns. While the analysis of the questionnaires and the interview data generated roughly comparable results, there were some interesting differences. The main difference was that the interviews demonstrated that the majority of the 13 distance learners interviewed would prefer more support and guidance rather than greater freedom as evident in the questionnaire data. The results of the interviews provide a useful supplement to the quantitative data and give us a better understanding of the factors that influence learners within a distance learning environment. 相似文献
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Cytokines are small proteins secreted by leukocytes in blood in response to infections, thus offering valuable diagnostic information. Given that the same cytokines may be produced by different leukocyte subsets in blood, it is beneficial to connect production of cytokines to specific cell types. In this paper, we describe integration of antibody (Ab) microarrays into a microfluidic device to enable enhanced cytokine detection. The Ab arrays contain spots specific to cell-surface antigens as well as anti-cytokine detection spots. Infusion of blood into a microfluidic device results in the capture of specific leukocytes (CD4 T-cells) and is followed by detection of secreted cytokines on the neighboring Ab spots using sandwich immunoassay. The enhancement of cytokine signal comes from leveraging the concept of reconfigurable microfluidics. A three layer polydimethylsiloxane microfluidic device is fabricated so as to contain six microchambers (1 mm × 1 mm × 30 μm) in the ceiling of the device. Once the T-cell capture is complete, the device is reconfigured by withdrawing liquid from the channel, causing the chambers to collapse onto Ab arrays and enclose cell/anti-cytokine spots within a 30 nl volume. In a set of proof-of-concept experiments, we demonstrate that ∼90% pure CD4 T-cells can be captured inside the device and that signals for three important T-cell secreted cytokines, tissue necrosis factor-alpha, interferon-gamma, and interleukin-2, may be enhanced by 2 to 3 folds through the use of reconfigurable microfluidics. 相似文献
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This study addressed the research question: How do Vietnamese principals lead the professional learning of teachers? The research was comprised of a multiple-site case study of leadership and teacher learning in four Vietnamese schools. Qualitative data analysis aimed at identifying modal practices adopted by these Vietnamese principals to lead teacher learning in their schools. The research identified four key leadership practices: moral purpose, collaboration, learning support, and motivational strategies. The findings support assertions for a broad set of globally-relevant school leadership practices as well as the need to adapt these to the cultural context of specific schools. 相似文献
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Tam Vu Ali Rahimian Gulnaz Stybayeva Yandong Gao Timothy Kwa Judy Van de Water Alexander Revzin 《Biomicrofluidics》2015,9(4)
Monocytes represent a class of immune cells that play a key role in the innate and adaptive immune response against infections. One mechanism employed by monocytes for sensing foreign antigens is via toll-like receptors (TLRs)—transmembrane proteins that distinguish classes of foreign pathogens, for example, bacteria (TLR4, 5, and 9) vs. fungi (TLR2) vs. viruses (TLR3, 7, and 8). Binding of antigens activates a signaling cascade through TLR receptors that culminate in secretion of inflammatory cytokines. Detection of these cytokines can provide valuable clinical data for drug developers and disease investigations, but this usually requires a large sample volume and can be technically inefficient with traditional techniques such as flow cytometry, enzyme-linked immunosorbent assay, or luminex. This paper describes an approach whereby antibody arrays for capturing cells and secreted cytokines are encapsulated within a microfluidic device that can be reconfigured to operate in serial or parallel mode. In serial mode, the device represents one long channel that may be perfused with a small volume of minimally processed blood. Once monocytes are captured onto antibody spots imprinted into the floor of the device, the straight channel is reconfigured to form nine individually perfusable chambers. To prove this concept, the microfluidic platform was used to capture monocytes from minimally processed human blood in serial mode and then to stimulate monocytes with different TLR agonists in parallel mode. Three cytokines, tumor necrosis factor-α, interleukin (IL)-6, and IL-10, were detected using anti-cytokine antibody arrays integrated into each of the six chambers. We foresee further use of this device in applications such as pediatric immunology or drug/vaccine testing where it is important to balance small sample volume with the need for high information content. 相似文献
25.
通过对青海省女子中长跑训练队12名队员进行的高原一平原—高原训练中血红蛋白含量测试及其变化,认为训练强度和身体适应密切相关,高原—平原—高原训练能有效地提高血红蛋白含量,加强训练与身体的生理适应程度,为今后训练提供科学依据． 相似文献
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Frequent requests from users to search engines on the World Wide Web are to search for information about people using personal names. Current search engines only return sets of documents containing the name queried, but, as several people usually share a personal name, the resulting sets often contain documents relevant to several people. It is necessary to disambiguate people in these result sets in order to to help users find the person of interest more readily. In the task of name disambiguation, effective measurement of similarities in the documents is a crucial step towards the final disambiguation. We propose a new method that uses web directories as a knowledge base to find common contexts in documents and uses the common contexts measure to determine document similarities. Experiments, conducted on documents mentioning real people on the web, together with several famous web directory structures, suggest that there are significant advantages in using web directories to disambiguate people compared with other conventional methods. 相似文献
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Vu TuongVan Magis-Weinberg Luc&#;a Jansen Brenda R. J. van Atteveldt Nienke Janssen Tieme W. P. Lee Nikki C. van der Maas Han L. J. Raijmakers Maartje E. J. Sachisthal Maien S. M. Meeter Martijn 《Educational Psychology Review》2022,34(1):39-71
Educational Psychology Review - The question of how learners’ motivation influences their academic achievement and vice versa has been the subject of intensive research due to its theoretical... 相似文献
28.
Mark T. Anderson Chau Vu K. Mark Derby Mary Goris T. F. McLaughlin 《Psychology in the schools》2002,39(1):73-76
Functional analysis methods were used to monitor medication used to reduce vocal and physical tics of a child with Tourettes Syndrome. An initial functional analysis suggested that the tics were maintained by automatic reinforcement. Given this result, the participant's physician prescribed Orap 1mg per day to reduce the tics. Post‐medication results demonstrated a reduced level of tics by the participant. Although preliminary, the findings suggest that functional analysis methods can be used to monitor the effects of medication in outpatient and school settings. Thus, more research using functional analyses to assess medication effects is needed. © 2002 John Wiley & Sons, Inc. 相似文献
29.
The first exhibition in Vietnam to feature Vietnamese Catholics was held from December 10, 2008 to June 10, 2009 at the Vietnam Museum of Ethnology in Hanoi. The theme of this exhibition was “Catholic Culture as an Intrinsic Part of Vietnamese Culture.” The exhibition was organized by a State‐run museum against a background of difficult relations between the State and its Catholic communities. This article explores how the exhibition was conceived, and how the ideas of the curators were implemented by examining negotiations among different stakeholders involved in the exhibition. 相似文献
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