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31.

This review examines the influence of dehydration on muscular strength and endurance and on single and repeated anaerobic sprint bouts. Describing hydration effects on anaerobic performance is difficult because various exercise modes are dominated by anaerobic energy pathways, but still contain inherent physiological differences. The critical level of water deficit (~ 3–4%; mode dependent) affecting anaerobic performance is larger than the deficit (~ 2%) impairing endurance performance. A critical performance-duration component (> 30 s) may also exist. Moderate dehydration (> 3% body weight; precise threshold depends on work/recovery ratio) impairs repeated anaerobic bouts, which place an increased demand on aerobic metabolism. Interactions between dehydration level, dehydration mode, testing mode, performance duration, and work/recovery ratio during repeated bouts make the dehydration thresh-old influencing anaerobic performance mode dependent.  相似文献   
32.
目的:筛选镉-硝酸盐共低积累空心菜基因型,并研究降低空心菜重金属含量,提高营养品质的农艺措施。创新点:首次筛选得到镉-硝酸盐共低积累空心菜基因型,并研究空心菜可食部污染物、矿质元素和营养指标之间的相关性,提出进一步降低空心菜可食部镉和硝酸盐含量的农艺措施。方法:共38个空心菜基因型收集于世界各地,种植在连作了7年的中度镉-硝酸盐复合污染土壤上(Cd1.10 mg/kg,NO_3~-235.2 mg/kg),4周后收获。用HNO_3-HClO_4(体积比5:1)消煮,电感耦合等离子体质谱仪(ICP-MS)测定各种金属元素,水杨酸-硫酸比色法测定硝酸盐含量,钒钼黄比色法测定磷含量,2,6-二氯靛酚滴定法测定维生素C含量,乙醇-丙酮(体积比2:1)比色法测定叶绿素含量。结论:本试验筛选得到镉-硝酸盐共低积累空心菜基因型4个(Cd0.71 mg/kg DW,NO_3~-3100 mg/kgFW),分别是JXDY、GZQL、XGDB和B888,可以在中轻度镉-硝酸盐复合污染土壤上安全生产。空心菜地上部镉与铅、锌含量呈正相关,而这3种元素均与磷量呈负相关。这些结果表明镉、铅和锌通过相同的途径被空心菜吸收,可以同时被治理。增加磷肥供应率可以抑制复合污染土壤中的镉和硝酸盐向空心菜可食部的转移。  相似文献   
33.
Carl Ludwig Schleich (1859–1922) was an anaesthetist and a surgeon who for the first time emphasized the role of neuroglia in brain function. In an era that was dominated by the idea that neurons alone were functional units of the nervous system and that glial cells were a mere glue holding neurons in place, Schleich insisted that glia had a prominent functional role to play. He suggested that interactions between neurons and glia were so strong that it is necessary to consider brain as a neuron-glia system whose performance is dependent on both the cell types. Today Carl Ludwig Schleich is considered the forgotten ancestor to a new breed of neurobiologists, the gliologists, who specialize in working on these neglected cells of the nervous system. Though outnumbering the neurons and occupying almost half the volume of the brain, glial cells have been given little importance in textbooks of neurobiology and are very often cursorily mentioned in discussions related to brain function. Glial cells deserve a better deal, for over the years a lot of evidence has accumulated to prove that they perform a wide spectrum of functions. This is the first of a series of articles that aims to update students on what is known about glia today. It provides an overview of the various types of glia and their origins. The following articles will deal with each of the glial sub-types and their functions.  相似文献   
34.
This article demonstrates how neoliberal higher education has come to play a distinct role in the global market for migrant labor, where a growing number of developing nations educate its citizens for overseas work in order to maximize future monetary remittances. Located in the Philippines, this study shows how local colleges and universities attempt to impose an ideal notion of flexibility, quickly shifting academic manpower and resources to programs that would produce the ‘right’ types of workers to address foreign labor demands. Based on qualitative interviews with Filipino college educators and students, the article then discusses how such ‘flexible’ strategies undermine the job security of college faculty and lead to the constant restructuring of physical space within university campuses. Such changes negatively affect both students and teachers.  相似文献   
35.
Mobile health clinics address the health needs of underserved populations by bringing healthcare to patients’ communities. Mobile health clinics find unique ways to treat patients and empower them to take control of their health. In this article, we examine how patients who use an urban mobile health clinic narrate their experiences on the clinic and what they see as the impact of the clinic on the community. A narrative of generosity emerged from the interviews, where patients believe the mobile health clinic creates a sense of welcome, encourages patients to become active participants in their health, and fosters a “pay it forward” attitude among community members.  相似文献   
36.
Chlorella vulgaris (CV) has been reported to have antioxidant and anticancer properties. We evaluated the effect of CV on apoptotic regulator protein expression in liver cancer-induced rats. Male Wistar rats (200-250 g) were divided into eight groups: control group (normal diet), CDE group (choline deficient diet supplemented with ethionine in drinking water to induce hepatocarcinogenesis), CV groups with three different doses of CV (50, 150, and 300 mg/kg body weight), and CDE groups treated with different doses of CV (50, 150, and 300 mg/kg body weight). Rats were sacrificed at various weeks and liver tissues were embedded in paraffin blocks for immunohistochemistry studies. CV, at increasing doses, decreased the expression of anti-apoptotic protein, Bcl-2, but increased the expression of pro-apoptotic protein, caspase 8, in CDE rats, which was correlated with decreased hepatoctyes proliferation and increased apoptosis as determined by bromodeoxy-uridine (BrdU) labeling and terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling (TUNEL) assay, respectively. Our study shows that CV has definite chemopreventive effect by inducing apoptosis via decreasing the expression of Bcl-2 and increasing the expression of caspase 8 in hepatocarcinogenesis-induced rats.  相似文献   
37.
Equitable computer collaborations in mixed-gender teams have been a pressing issue for many years. While some have argued for creating single-gender teams or girls-only computer activities, our approach was different. The current study examines a three-month software design activity in which mixed teams of girls and boys (10–12 year olds) designed and implemented multimedia astronomy resources for younger students. In this context we assessed gender differences in students' levels of access to technology and how these participation patterns changed throughout the project duration. We found through our qualitative analyses that the configuration of social, physical and cognitive spaces in the project environment contributed to a positive change in girls' levels of access. We discuss the implications of these results in regard to issues surrounding the development and maintenance of gender equity in computer use and further research.  相似文献   
38.
39.
Given the increased need for broadening participation in computing, there must be a focus not just on providing culturally relevant content but also on building accessible and inclusive computational tools. Most efforts to design culturally responsive computational tools redesign surface features, often through making nominal changes to add cultural meaning, yet the deeper structural design remains largely intact. We take a critical perspective towards novice programming environments to elucidate how the underlying structure privileges particular epistemologies and cultures. In this paper, we examine how the cultural practice of storytelling is supported and/or inhibited within novice programming tools. We draw upon the experiences of 38 Native American youth, who worked in teams to create place-based, interactive stories and games for their community. Findings offer insights to the embedded cultural biases that exist in the structures of computational tools. We discuss insights for how to address cultural biases and promote deeper integration of cultural practices in future designs of culturally responsive computational tools.

Practitioner Notes

What is already known about this topic?
  • Culturally responsive computing connects computing content heritage and vernacular cultural practices.
  • “Black boxing,” or lack of transparency in how it works, in computational tools makes it difficult for novices to enter computing cultures.
  • Design tools are embedded with particular ways of being, knowing, valuing and doing.
What this paper adds?
  • Thirty-eight novice learners’ computational designs were shaped by the ways in which a computational tool privileged particular knowledge systems.
  • Storytelling, as a critical cultural practice, especially in Indigenous cultures, is heavily constrained by the design structure of computational tools.
  • Computational tools are cultural artifacts with deeply embedded epistemological, ontological and axiological biases, which directly frame what learners can do with these tools.
Implications for practice
  • Collaborative, community-based design processes could mitigate the cultural biases that persist in computational tools.
  • Transparency in computation tools in critical to broadening participation in computing cultures.
  • Culturally responsive design of computational tools at the structural level is required to build inclusive computing cultures.
  相似文献   
40.
研究目的:探讨萎叶(PB)提取物对5-氟尿嘧啶(5-FU)抑制结肠癌细胞HT29和HCT116生长的影响。研究方法:HT29和HCT116细胞分别给予PB、5-FU以及两种药物联合治疗24小时,应用等效线图法分析PB和5-FU的药效学相互作用,AnnexinV/PI染色法检测HT29和HCT116细胞的凋丁L=情况,高效液相色谱法排除PB和5-FU间任何可能的相互化学作用。重要结论:联合PB,低剂量5-FU可以在短时间内起到细胞毒作用,而单独应用PB或5-FU治疗较联合治疗可以诱导更多细胞发生凋亡。进一步采用等效线图法分析显示PB和5-Fu的联合作用在抑制结肠癌细胞HT29和HCT116的生长中分别体现出协同和拮抗作用。因此可以认为在HT29细胞中,PB使得较低剂量5-FU发挥最大抑制结肠癌细胞生长效果,然而在HCT116细胞中,PB没有显著降低5-FU的药物浓度,说明PB和5-FU的相互作用不仅仅体现在诱导细胞凋亡方面。  相似文献   
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