Review:On dendritic cell-based therapy for cancers     

Morikazu Onji  Sk.Md.Fazle Akbar 《Journal of Zhejiang University. Science. B》2005,(1)

Dendritic cells(DCs),the most prevalent antigen-presenting cell in vivo,had been widely characterized in the lastthree decades.DCs are present in almost all tissues of the body and play cardinal roles in recognition of microbial agents,autoantigens,allergens and alloantigen.DCs process the microbial agents or their antigens and migrate to lymphoid tissues topresent the antigenic peptide to lymphocytes.This leads to activation of antigen-specific lymphocytes.Initially,it was assumedthat DCs are principally involved in the induction and maintenance of adaptive immune responses,but now it is evident that DCsalso have important roles in innate immunity.These features make DCs very good candidates for therapy against variouspathological conditions including malignancies.Initially,DC-based therapy was used in animal models of cancers.Data fromthese studies inspired considerable optimism and DC-based therapies was started in human cancers 8 years ago.In general,DC-based therapy has been found to be safe in pati  相似文献   

Robust FOPID stabilization of retarded type fractional order plants with interval uncertainties and interval time delay     

Majid Ghorbani  Mahsan Tavakoli-Kakhki  Ali Akbar Estarami 《Journal of The Franklin Institute》2019,356(16):9302-9329

This study investigates the robust stability of the retarded type of interval fractional order plants with an interval time delay. To this end, the characteristic quasi-polynomial is divided into two terms. The first term is simply the denominator interval polynomial of the open loop system and the second term is the multiplication of the interval delay term in the numerator of the open loop system which is an interval polynomial. Each of these two terms of the characteristic quasi-polynomial makes their own value sets in the complex plane for a given frequency. In this paper, based on these two value sets and by using the zero exclusion principle, the robust stability of the closed loop system by applying a FOPID controller is analyzed. Finally, two numerical examples and an experimental verification are provided to demonstrate the effectiveness of the proposed method in the robust stabilization of fractional order plants with interval uncertainties and interval time delay.  相似文献   

Boxes,Stems and Leaves at “A”-level     

Aysha Akbar 《Teaching Statistics》1991,13(2):57-59

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Estimating seismic demand parameters using the endurance time method     

Ramin Madarshahian  Homayoon Estekanchi  Akbar Mahvashmohammadi 《浙江大学学报(A卷英文版)》2011,12(8):616-626

The endurance time (ET) method is a time history based dynamic analysis in which structures are subjected to gradually intensifying excitations and their performances are judged based on their responses at various excitation levels. Using this method, the computational effort required for estimating probable seismic demand parameters can be reduced by an order of magnitude. Calculation of the maximum displacement or target displacement is a basic requirement for estimating performance based on structural design. The purpose of this paper is to compare the results of the nonlinear ET method with the nonlinear static pushover (NSP) method of FEMA 356 by evaluating performances and target displacements of steel frames. This study will lead to a deeper insight into the capabilities and limitations of the ET method. The results are further compared with those of the standard nonlinear response history analysis. We conclude that results from the ET analysis are in proper agreement with those from standard procedures.  相似文献   

On dendritic cell-based therapy for cancers   总被引：3，自引：0，他引：3  

Onji M  Akbar SM 《Journal of Zhejiang University. Science. B》2005,6(1):1-3

Dendritic cells (DCs), the most prevalent antigen-presenting cell in vivo, had been widely characterized in the last three decades. DCs are present in almost all tissues of the body and play cardinal roles in recognition of microbial agents,autoantigens, allergens and alloantigen. DCs process the microbial agents or their antigens and migrate to lymphoid tissues to present the antigenic peptide to lymphocytes. This leads to activation of antigen-specific lymphocytes. Initially, it was assumed that DCs are principally involved in the induction and maintenance of adaptive immune responses, but now it is evident that DCs also have important roles in innate immunity. These features make DCs very good candidates for therapy against various pathological conditions including malignancies. Initially, DC-based therapy was used in animal models of cancers. Data from these studies inspired considerable optimism and DC-based therapies was started in human cancers 8 years ago. In general,DC-based therapy has been found to be safe in patients with cancers, although few controlled trials have been conducted in this regard. Because the fundamentals principles of human cancers and animal models of cancers are different, the therapeutic efficacy of the ongoing regime of DC-based therapy in cancer patients is not satisfactory. In this review, we covered the various aspects that should be considered for developing better regime of DC-based therapy for human cancers.  相似文献   

Uniform exponential stability of periodic discrete switched linear system     

Akbar Zada  Bakht Zada  Jinde Cao  Tongxing Li 《Journal of The Franklin Institute》2017,354(14):6247-6257

Let {Π_τ(m, n): m?≥?n?≥?0} be the family of periodic discrete transition matrices generated by bounded valued square matrices Λ_τ(n), where $\tau :[0,1,2,?)\to \Omega$ is an arbitrary switching signal. We prove that the family {Π_τ(m, n): m?≥?n?≥?0} of bounded linear operator is uniformly exponentially stable if and only if the sequence $n?{\sum }_{k=0}^n{e}^{i\alpha k}{\Pi }_{\tau }(n,k)w\left(k\right):{\mathbb{Z}}_{+}\to \mathbb{R}$ is bounded.  相似文献   

Iron determinatioin after on-line sorbent preconcentration by FI-FASS using 1,10-phenanthroline as a complexing agent     

Akbar Ali  YE Ying-xue  XU Guang-ming  ZHANG Tao  YIN Xue-feng  JIN Xin 《浙江大学学报(A卷英文版)》2000,1(1)

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An evaluation of information behaviour studies through the Scholarly Capital Model          下载免费PDF全文

Faramarz Soheili  Ali Akbar Khasseh  Afshin Mousavi Chelak  Mohammad Tavakolizadeh‐Ravari 《Learned Publishing》2018,31(2):121-129

Influence and capital are two concepts used to evaluate scholarly outputs, and these can be measured using the Scholarly Capital Model as a modelling tool. The tool looks at the concepts of connectedness, venue representation, and ideational influence using centrality measures within a social network. This research used co‐authorships and h‐indices to investigate authors who have published papers in the field of information behaviour between 1980 and 2015 as extracted from Web of Science. The findings show a relationship between the authors’ connectedness and the venue (journal) representation. It could be seen that the venue (journal) influences the chance of citation, and equally, the prestige (centrality) of authors probably raises the citations of the journals. The research also shows a significant positive relationship between the venue representation and ideational influence. This means that a research work that is published in a highly cited journal will find more visibility and will receive more citations.  相似文献   

Corrigendum to “Robust FOPID stabilization of retarded type fractional order plants with interval uncertainties and interval time delay” [Journal of the Franklin Institute Volume 356, Issue 16, 2019, Pages 9302–9329]     

Majid Ghorbani  Mahsan Tavakoli-Kakhki  Ali Akbar Estarami 《Journal of The Franklin Institute》2021,358(2):1692

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