Serum Levels of Glycoproteins are Elevated in Patients with Ovarian Cancer     

Vikram Thakkar  Purvi Patel  Neelam Prajapati  Ranjit Kaur  Mukesh Nandave 《Indian journal of clinical biochemistry : IJCB》2014,29(3):345-350

Identification of reliable biomarkers for detection and staging of cancer and monitoring the outcome of anticancer therapy has been considered to be of high importance. We aimed to estimate the levels of serum glycoproteins, protein bound-hexose, protein bound hexosamine, protein bound fucose, protein bound sialic acid and protein bound carbohydrate in 32 ovarian cancer patients and compared them with the levels that found in 25 normal subjects. As compared to the normal subjects, all the four fractions of glycoproteins level were significantly elevated in ovarian cancer patients (p < 0.05). Chemotherapy in these patients significantly decreased the levels of serum glycoproteins (p < 0.05). Thus, high levels of serum glycoproteins in ovarian cancer patients could be due to abnormal protein glycosylation indicating malignant transformation of the cells.  相似文献   

Diagnostic Value of Lactate Levels in Acute Abdomen Disorders     

Indu Verma  Satinder Kaur  Subash Goyal  Shweta Goyal  J. S. Multani  A. P. S. Narang 《Indian journal of clinical biochemistry : IJCB》2014,29(3):382-385

The supply of oxygen is limited in certain intra abdominal conditions due to direct vascular invasion or inflammatory process, resulting in high lactate levels. Aim of this study was to find the predictive value of lactate levels in the peritoneal fluid (PF) and blood of patients with acute abdomen. The study comprised of fifty patients with acute abdominal conditions, admitted in emergency ward of tertiary care hospital, thirty patients were with surgical abdomen (group I) and twenty patients with non surgical abdomen (group II). Lactate was estimated in PF and blood on Blood Gas Analyzer (NOVA, M-7). The mean lactate levels in PF were significantly higher in group I as compared to group II (14.65 ± 1.195 vs. 5.92 ± 0.97 mmol/L, p < 0.001). There was no significant difference in blood lactate levels in both the groups. When PF and blood lactate levels were compared within groups, we found that PF levels were significantly higher than blood in group I (14.65 ± 1.195 vs. 3.85 ± 0.54 mmol/L, p < 0.001) but not in group II (5.92 ± 0.97 vs. 4.36 ± 0.95 mmol/L). Diagnostic value was obtained using ROC curve. Cut off values obtained for PF lactate, difference and ratio of PF and blood lactate (≥6.4 mmol/L, ≥3.3 and ≥2.1 respectively) are at very high degree of sensitivity and specificity. So it can be useful marker of surgical emergency in patients with acute intra abdominal pathology, especially in clinically ill patients or in whom physical examination is not yielding because of neurologic disorders or unresponsiveness.  相似文献   

Probing transient protein-mediated DNA linkages using nanoconfinement     

Maedeh Roushan  Parminder Kaur  Alena Karpusenko  Preston J. Countryman  Carlos P. Ortiz  Shuang Fang Lim  Hong Wang  Robert Riehn 《Biomicrofluidics》2014,8(3)

We present an analytic technique for probing protein-catalyzed transient DNA loops that is based on nanofluidic channels. In these nanochannels, DNA is forced in a linear configuration that makes loops appear as folds whose size can easily be quantified. Using this technique, we study the interaction between T4 DNA ligase and DNA. We find that T4 DNA ligase binding changes the physical characteristics of the DNA polymer, in particular persistence length and effective width. We find that the rate of DNA fold unrolling is significantly reduced when T4 DNA ligase and ATP are applied to bare DNA. Together with evidence of T4 DNA ligase bridging two different segments of DNA based on AFM imaging, we thus conclude that ligase can transiently stabilize folded DNA configurations by coordinating genetically distant DNA stretches.  相似文献   

Correction to: Combined Analysis of Anti SARS-CoV-2 IgG and IgM Responses in COVID19 Patients in India     

Mohana Kumari Chidananda  Deepy Zohmangaihi  Sant Ram  Shiv Lal Vikas SoniSuri  Pankaj Malhotra  Ravjit Singh Jassal  Jyotdeep Kaur  Indu Verma  Sadhna Sharma 《Indian journal of clinical biochemistry : IJCB》2021,36(4):501

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Statistics Education in Singapore Schools     

Lionel Pereira-Mendoza  Berinderjeet Kaur 《Teaching Statistics》1998,20(2):38-42

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Ultrasound: A boon in the synthesis of organic compounds     

Vasundhara Singh  Kanwal Preet Kaur  Anupam Khurana  G. L. Kad 《Resonance》1998,3(9):56-60

The use of ultrasound for promoting chemical reactions is described.  相似文献