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The use of R&D grants as a policy instrument has been motivated by economic arguments of market failure. Neo-classical econometric studies have analysed the additionality of one Euro of subsidies on both the investments of companies in the R&D process and the output of that R&D process. More recently, behavioural additionality has been launched as a third form of additionality. In contrast to input and output additionality, behavioural additionality is related to changes in the processes that take place within the firm. In this paper, we analyse the determinants of the behavioural additionality of R&D grants. To explain the mechanism through which behavioural additionality is obtained, we use organizational learning theory as a guide to formulate our hypotheses. Hypotheses are tested using a telephone survey of 192 recipients of R&D grants provided by the IWT in Flanders in 2001–2004, matched to a sample of 84 firms that undertake innovation activities but which had never had a grant bid accepted. We find that congenital learning and interorganizational learning lead to increased behavioural additionality. However, these learning effects decrease with the number of subsidized projects that are undertaken by the company. 相似文献
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Yegermal Tesfaw Atalay Daan Witters Steven Vermeir Nicolas Vergauwe Pieter Verboven Bart Nicola? Jeroen Lammertyn 《Biomicrofluidics》2009,3(4)
An electrokinetic driven microfluidic lab-on-a-chip was developed for glucose quantification using double-enzyme assay. The enzymatic glucose assay involves the two-step oxidation of glucose, which was catalyzed by hexokinase and glucose-6-phosphate dehydrogenase, with the concomitant reduction of NADP+ to NADPH. A fluorescence microscopy setup was used to monitor the different processes (fluid flow and enzymatic reaction) in the microfluidic chip. A two-dimensional finite element model was applied to understand the different aspects of design and to improve the performance of the device without extensive prototyping. To our knowledge this is the first work to exploit numerical simulation for understanding a multisubstrate double-enzyme on-chip assay. The assay is very complex to implement in electrokinetically driven continuous system due to the involvement of many species, which has different transport velocity. With the help of numerical simulation, the design parameters, flow rate, enzyme concentration, and reactor length, were optimized. The results from the simulation were in close agreement with the experimental results. A linear relation exists for glucose concentrations from 0.01 to 0.10 g l−1. The reaction time and the amount of enzymes required were drastically reduced compared to off-chip microplate analysis. 相似文献
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ABSTRACTThis paper provides the climate specifications of several museums in the Netherlands that have been renovated. These climate specifications developed in the last two decades are very similar, and hence demonstrate that not much has changed in 20 years. Since the use of the climate classes presented by ASHRAE often plays a major role in developing climate specifications in Dutch museums, an analysis was made of its pros and cons. Issues concerning the use of the ASHRAE table are presented: the table is used as a list, the meaning of short fluctuations is unclear, and translating the numbers to a control algorithm is troublesome. An alternative table is presented for temperature and relative humidity specifications to overcome these issues. 相似文献
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This paper considers the question of whether the resource endowments of science-based entrepreneurial firms are influenced by the way technology transfer is organised at the parent organisation. We studied one public research organisation in detail (IMEC, Belgium), by questioning all managers involved in technology transfer and the founders of all science-based entrepreneurial firms set up between 1986 and 2002. This research identifies three generations of companies at IMEC, mirroring the organisational changes in technology transfer policies and displaying distinct resource characteristics. Establishing an incubator structure for spin-offs seems to be a learning process during which little decision making can be exerted over senior management's social network in the financial and business community for securing the financial, technological and human resources for the science-based entrepreneurial firms. 相似文献
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Delayed diagnosis and treatment of extreme hypertriglyceridemia due to rejection of a lipemic sample
Jan Van Elslande Samira Hijjit Katrien De Vusser Michel Langlois Bjrn Meijers Ann Mertens Bart Van der Schueren Glynis Frans Pieter Vermeersch 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(2)
IntroductionMost laboratories routinely determine haemolysis, icterus and lipemia indices to identify lipemic samples and reject potentially affected results. Hypertriglyceridemia is the most common cause of lipemia and severe hypertriglyceridemia (≥ 11.3 mmol/L) is a major risk factor of acute pancreatitis.Laboratory analysisA 56-year-old woman attended the outpatient clinic for a follow-up visit 1 month after a kidney transplantation. Her immunosuppressive therapy consisted of corticosteroids, cyclosporine, and mycophenolic acid. The routine clinical chemistry sample was rejected due to extreme lipemia. The comment “extreme lipemic sample” was added on the report, but the requesting physician could not be reached. The Cobas 8000 gave a technical error (absorption > 3.3) for the HIL-indices (L-index: 38.6 mmol/L) which persisted after high-speed centrifugation. The patient was given a new appointment 2 days later. The new sample was also grossly lipemic and gave the same technical error (L-index: 35.9 mmol/L).What happenedThe second sample was manually diluted 20-fold after centrifugation to obtain a result for triglycerides within the measuring range (0.10–50.0 mmol/L). Triglycerides were 169.1 mmol/L, corresponding to very severe hypertriglyceridemia. This result was communicated to the nephrologist and the patient immediately recalled to the hospital. She received therapeutic plasma exchange the next day and did not develop acute pancreatitis.Main lessonThis case illustrates the delicate balance between avoiding the release of unreliable results due to lipemia and the risk of delayed diagnosis when results are rejected. Providing an estimate of the degree of hypertriglyceridemia might be preferable to rejecting the result. 相似文献
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Bart W. Schermer Bart Custers Simone van der Hof 《Ethics and Information Technology》2014,16(2):171-182
In this article we examine the effectiveness of consent in data protection legislation. We argue that the current legal framework for consent, which has its basis in the idea of autonomous authorisation, does not work in practice. In practice the legal requirements for consent lead to ‘consent desensitisation’, undermining privacy protection and trust in data processing. In particular we argue that stricter legal requirements for giving and obtaining consent (explicit consent) as proposed in the European Data protection regulation will further weaken the effectiveness of the consent mechanism. Building on Miller and Wertheimer’s ‘Fair Transaction’ model of consent we will examine alternatives to explicit consent. 相似文献
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The objective of this study was to analyse the correctness of the offside judgements of the assistant referees during the final round of the FIFA 2002 World Cup. We also contrasted two hypotheses to explain the errors in judging offside. The optical error hypothesis is based on an incorrect viewing angle, while the flash-lag hypothesis refers to perceptual errors associated with the flash-lag effect (i.e. a moving object is perceived as spatially leading its real position at a discrete instant signalled by a briefly flashed stimulus). Across all 64 matches, 337 offsides were analysed using digital video technology. The error percentage was 26.2%. During the first 15 min match period, there were significantly more errors (38.5%) than during any other 15 min interval. As predicted by the flash-lag effect, we observed many more flag errors (86.6%) than non-flag errors (13.4%). Unlike the predictions of the optical error hypothesis, there was no significant difference between the correct and incorrect decisions in terms of the positioning of the assistant referees relative to the offside line (0.81 and 0.77 m ahead, respectively). To reduce the typical errors in judging offside, alternative ways need to be considered to teach assistant referees to better deal with flash-lag effects. 相似文献
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Siegler's rule assessment methodology was used to investigate the cognitive effects of a 32 hour mathematics in-service workshop on 28 elementary shool teachers. This paper reports on attempts (a) to assess the levels of cognitive understanding of the basic concepts of proportion, probability, and correlation among elementary teachers, and (b) to change teachers' levels in understanding these concepts by a method of direct instruction. Significant improvements were noted in the levels of cognitive development associated with the concept of proportion. Though nonsignificant improvements were noted in the concepts of probability and correlation, all the teachers were assigned to the highest cognitive rule associated with the probability concept at the end of the workshop. 相似文献