補習學校与監護員制     

H.Z. 《教育与职业》1925,(0)

补习教育行政上有一公认之原则·即其组织须有伸缩余地·补习学校兼含教育机关与社会机关两种作用·故其机构必求完密·足以引起学生之尊重·其支配必求确可伸缩自由·俾能保持学校·工作·社会三方面调合可能·而尤以后者为学生在学期内人人所必要·  相似文献   

坐     

H.E.弗朗西斯美 《大中专文苑》2015,(2)

那男人和女人坐在他们面前的台阶上,坐了一整天,一动也不动。他每隔一阵子就从前门的玻璃偷看他们一下。天黑了,他们还不走,他怀疑他们什么时候吃东西、睡觉、做其他的事情。黎明时,他们还坐在那儿,坐在那儿任凭日晒雨淋。  相似文献   

Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions     

Zhao Q  Liu ZD  Xue Y  Wang JF  Li H  Tang QJ  Wang YM  Dong P  Xue CH 《Journal of Zhejiang University. Science. B》2011,12(7):534-544

Ds-echinoside A (DSEA), a non-sulfated triterpene glycoside, was isolated from the sea cucumber Pearsonothuria graeffei. In vitro and in vivo investigations were conducted on the effects of DSEA on tumor cell adhesion, migration, invasion, and angiogenesis. In this study, we found that DSEA inhibited the proliferation of human hepatocellular liver carcinoma cells Hep G2, with a half-maximal inhibitory concentration (IC₅₀) of 2.65 μmol/L, and suppressed Hep G2 cell adhesion, migration, and invasion in a dose-dependent manner. DSEA also reduced tube formation of human endothelial cells ECV-304 on matrigel in vitro and attenuated neovascularization in the chick embryo chorioallantoic membrane (CAM) assay in vivo. Immunocytochemical analysis revealed that DSEA significantly decreased the expression of matrix metalloproteinase-9 (MMP-9), which plays an important role in the degradation of basement membrane in tumor metastasis and angiogenesis. DSEA also increased the protein expression level of tissue inhibitor of metalloproteinase-1 (TIMP-1), an important regulator of MMP-9 activation. From the results of Western blotting, the expressions of nuclear factor-kappa B (NF-κB) and vascular endothelial growth factor (VEGF) were found to be remarkably reduced by DSEA. These findings suggest that DSEA exhibits a significant antimetastatic activity through the specific inhibition of NF-κB-dependent MMP-9 and VEGF expressions.  相似文献   

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery     

Hu QD  Fan H  Lou WJ  Wang QQ  Tang GP 《Journal of Zhejiang University. Science. B》2011,12(9):720-729

Polyethylenimine-cyclodextrin-tegafur (PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein (EGFP) reporter plasmid DNA. Conjugation of tegafur to PEI-CyD via chemical linkage was characterized by ¹H NMR spectrometry and ultraviolet (UV) spectrometry. PEI-CyD-tegafur was able to condense plasmid DNA into complexes of around 150 nm with positive charge at the N/P ratio of 25, in accordance with electron microscopy observation of compact and monodisperse nanoparticles. The results of in vitro experiments showed enhanced cytotoxicity and considerable transfection efficiency in B16F10 cell line. Therefore, PEI-CyD-tegafur may have great potential as a co-delivery system with anti-cancer activity and potential for gene delivery.  相似文献   

A Comprehensive Analysis of High School Genetics Standards: Are States Keeping Pace with Modern Genetics?     

Dougherty MJ  Pleasants C  Solow L  Wong A  Zhang H 《CBE life sciences education》2011,10(3):318-327

Science education in the United States will increasingly be driven by testing and accountability requirements, such as those mandated by the No Child Left Behind Act, which rely heavily on learning outcomes, or "standards," that are currently developed on a state-by-state basis. Those standards, in turn, drive curriculum and instruction. Given the importance of standards to teaching and learning, we investigated the quality of life sciences/biology standards with respect to genetics for all 50 states and the District of Columbia, using core concepts developed by the American Society of Human Genetics as normative benchmarks. Our results indicate that the states' genetics standards, in general, are poor, with more than 85% of the states receiving overall scores of Inadequate. In particular, the standards in virtually every state have failed to keep pace with changes in the discipline as it has become genomic in scope, omitting concepts related to genetic complexity, the importance of environment to phenotypic variation, differential gene expression, and the differences between inherited and somatic genetic disease. Clearer, more comprehensive genetics standards are likely to benefit genetics instruction and learning, help prepare future genetics researchers, and contribute to the genetic literacy of the U.S. citizenry.  相似文献   

我的韩国母亲     

Mary H.K.Choi  佚名 《高中生》2015,(1):26-27

我很爱我的母亲,哪怕她会在我热泪汪汪时,强迫我给远亲们打电话,拨出号码并把听筒按在我的脸颊上,在这个时候,我仍然爱着她。她总是爱发威。有一次在杂货店里,她竟然一把将我丢到地上,以此警告我别没大没小。她是我的最爱,也让我抓狂。她真的有点"奇葩"。你会觉得让她吃商店里买的点心就像要了她的命似的。她在韩国长大,周围都是韩国人,后来嫁了个韩国人,接着在35岁左右搬到了香  相似文献   

All by Myself     

H．W．Longfellow  田仁芳 《中学生英语》2010,(5):1-1

有很多事情我可以做 自己动手; 我会梳头和系鞋带 自己动手； 我会洗手和洗脸 自己动手；  相似文献   

运动训练对肾上腺素分泌的影响(摘要)     

M·卡捷尔  H·高尔博  陈佩蕴 《山东体育科技》1989,(1)

研究表明:经过耐力训练的运动员其肾上腺素分泌水平在低血糖时和经过相同的有关工作负荷后要比没经过训练的个体高。我们假设运动训练能增加肾上腺髓质的分泌能力,为证明这一假设对胰高血糖素(每70公斤体重1毫克,静脉注射)、急性血碳酸过高(吸入的氧只有7%)和急性低气压缺氧(吸入的氧分压只有87毫米汞柱)的作用进行了研究。研究对象是8个经过耐力训练的运动员和7个从事办公室工作的成年男性。前者为检测组(氧摄入量=66毫升/分/公  相似文献   

The More Loving One     

W.H.奥登 《英语辅导》2003,(40)

仰望群星的时分,我一清二楚,尽管它们关怀备至,我亦有可能赴地府,可是尘世间我们丝毫不必畏惧人类或禽兽的那份冷漠。  相似文献   

“国际教练纵队”     

沈楠 《中国体育(中英文版)》2004,(8)

在雅典奥运会中国军团里,有这样一些人,他们或有着不同的肤色、发色,或操着不同的语言,但是他们有一个共同点——为中国而战,这就是中国军团中的“国际教练纵队”。 哈里斯:来自NBA的“狐狸” 在开始中国“冒险之旅”前,哈里斯告诉NBA官方网站:这项任务的最难之处就是语言。从踏上中国的土地,学中文成了他的头等大事。然而到达中国的第二天,他就发现,这份工作的最大挑战似乎并不是语言,他甚至开始后悔接手这支连没有一个奥运会队员的澳大利亚明星队都可以“践踏”的球队。对于这样的“见面礼”,即使是外表温文尔雅的哈里斯也无法消受,他…  相似文献