HLA Gene in 5 Cases of Liver Injury Related to Baikal Skullcap     

Naoki Mantani  Hiroshi Oka  Takashi Watanabe  Kyohei Miyakawa  Yoko Kimura 《Indian journal of clinical biochemistry : IJCB》2021,36(3):375

HLA association with drug-induced liver injury has recently been pointed out about multiple medicines. The aim of this study was to evaluate relationship between HLA gene and liver injury related to Baikal skullcap-containing Kampo medicines (BSCK). We previously examined HLA genes in 3 cases of BSCK-induced liver injury. Recently we could encounter 2 cases diagnosed as “definitely-related case” of BSCK-induced liver injury. HLA genes of the 2 cases were analyzed by Sequencing Based Typing method with Next Generation Sequencer at HLA Laboratory in Kyoto. HLA-DPA1*02:02:02 and DPB1*05:01:01 were observed in the 2 cases: concordance was not observed in HLA-A, B, C, DRB1, DRB4, DQA1, or DQB1. The previous 3 cases of BSCK-induced liver injury had the same allele type to the 2 cases only in HLA-DPA1. Putting all these together, HLA-DPA1*02:02:02 was observed in common among 5 cases of BSCK-induced liver injury. HLA-DPA1*02:02:02 is possibly associated with BSCK-induced liver injury.  相似文献   

Education for Persons with Handicaps in Japan,the USA and Sweden     

Gary Miron  Hiroshi Katoda 《Scandinavian Journal of Educational Research》2013,57(3):163-178

Abstract

This paper deals with educational provision for persons with handicaps and the trend toward educational integration. The cases of Japan, the USA and Sweden are considered and compared. While the development of treatment for persons with handicaps is not very different among these three countries, there are obvious differences in the implementation and acceptance of integration among them. Sweden seems to have adapted best to the philosophy of normalization and the process of integration, while in Japan, and to a lesser extent the USA, the debate and conflict that arose with their introduction and development was much more intense and remains heated even today.  相似文献   

Determination method for power-saved driving motions of manipulators by heuristic algorithms (in case of PTP control)     

Michihiro Hayashi  Hiroshi Tachiya  Naoki Asakawa  Takuya Kawamura 《Journal of The Franklin Institute》2011,348(1):101-111

This study proposed a method for suppressing torques and consumed energy of manipulators considering an effect of inertial forces in order to achieve power-saved drive. The present paper describes the case that the start and end points of a work path of a manipulator are specified and the path between the points can be determined arbitrarily, which is so-called point-to-point (PTP) control. The proposed method determines both the initial pose of a manipulator and input motions of its joints so that the torque or consumed energy is suppressed. The input motion of the joint is expressed by a motion curve that indicates the time profiles of input displacements, velocities and accelerations. The proposed method determines the motion curve as a polynomial with appropriate coefficients. Those coefficients and their values are decided by a heuristic algorithm in order to suppress the input torques or consumed energy of a manipulator. The paper actually determines the power-saved drive motion of “PUMA560” by the proposed method and reveals its effectiveness.  相似文献   

Electromyographic analysis of hip adductor muscles in soccer instep and side-foot kicking     

Kohei Watanabe  Hiroyuki Nunome  Koichiro Inoue  Takahiro Iga  Hiroshi Akima 《Sports biomechanics / International Society of Biomechanics in Sports》2020,19(3):295-306

ABSTRACT

A possible link between soccer-specific injuries, such as groin pain and the action of hip adductor muscles has been suggested. This study aimed to investigate neuromuscular activation of the adductor magnus (AM) and longus (AL) muscles during instep and side-foot soccer kicks. Eight university soccer players performed the two types of kick at 50%, 75% and 100% of the maximal ball speed. Surface electromyography (EMG) was recorded from the AM, AL, vastus lateralis (VL) and biceps femoris (BF) muscles of both kicking and supporting legs and the kicking motions were three-dimensionally captured. In the kicking leg, an increase in surface EMG with an increase in ball speed during instep kicking was noted in the AM muscle (p < 0.016), but not in AL, VL or BF muscles (p > 0.016). In the supporting leg, surface EMG of both AM and AL muscles was significantly increased with an increase in the ball speed before ball impact during both instep and side-foot kicks (p < 0.016). These results suggest that hip adductor muscles markedly contribute to either the kicking or supporting leg to emphasise the action of soccer kicks.  相似文献   

Educational Administration in Japan     

Hiroshi Kida 《比较教育学》1986,22(1):7-12

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Stroke phase discrimination in breaststroke swimming using a tri-axial acceleration sensor device   总被引：3，自引：1，他引：2  

Yuji?OhgiEmail author  Hiroshi?Ichikawa  Masanobu?Homma  Chikara?Miyaji 《Sports Engineering》2003,6(2):113-123

Our previous study has demonstrated that the swimmer’s wrist acceleration in the crawl stroke and the breaststroke had distinctive characteristics between subjects (Ohgiet al. 2000). In addition, stroke phase discrimination could be achieved for the crawl stroke by using the swimmer’s wrist acceleration. This study provides evidence that the swimmer’s tri-axial wrist acceleration could be used for stroke phase discrimination in the breaststroke. Swimmers’ triaxial wrist accelerations were measured and their underwater stroke paths calculated. The authors examined the characteristics of the wrist acceleration, such as a local maximum or minimum, with reference to the swimmers’ stroke paths. As a result, it was suggested that the three phases of the breaststroke, the recovery, the insweep and the outsweep, could be distinguished using thex-axis (ulnar-radial axis) and they-axis (distal-proximal axis) acceleration. This methodology allows us to identify which stroke phase would be changed in skill training or over training, and the acceleration sensor device has the potential to become a precise stroke pedometer or stroke monitoring tool in the near future.  相似文献   

Surface modification on polydimethylsiloxane-based microchannels with fragmented poly(l-lactic acid) nanosheets     

Lu Yang  Yosuke Okamura  Hiroshi Kimura 《Biomicrofluidics》2015,9(6)

Surface modification is a critical issue in various applications of polydimethylsiloxane (PDMS)-based microfluidic devices. Here, we describe a novel method through which PDMS-based microchannels were successfully modified with fragmented poly(l-lactic acid) (PLLA) nanosheets through a simple patchwork technique that exploited the high level of adhesiveness of PLLA nanosheets. Compared with other surface modification methods, our method required neither complicated chemical modifications nor the use of organic solvents that tend to cause PDMS swelling. The experimental results indicated that the modified PDMS exhibited excellent capacity for preventing the adhesion and activation of platelets. This simple yet efficient method can be used to fabricate the special PDMS microfluidic devices for biological, medical, and even hematological purposes.  相似文献   

Three-dimensional two-component velocity measurement of the flow field induced by the Vorticella picta microorganism using a confocal microparticle image velocimetry technique     

Moeto Nagai  Masamichi Oishi  Marie Oshima  Hiroshi Asai    Hiroyuki Fujita 《Biomicrofluidics》2009,3(1)

Understanding the biological feeding strategy and characteristics of a microorganism as an actuator requires the detailed and quantitative measurement of flow velocity and flow rate induced by the microorganism. Although some velocimetry methods have been applied to examine the flow, the measured dimensions were limited to at most two-dimensional two-component measurements. Here we have developed a method to measure three-dimensional two-component flow velocity fields generated by the microorganism Vorticella picta using a piezoscanner and a confocal microscope. We obtained the two-component velocities of the flow field in a two-dimensional plane denoted as the XY plane, with an observation area of 455×341 μm² and the resolution of 9.09 μm per each velocity vector by a confocal microparticle image velocimetry technique. The measurement of the flow field at each height took 37.5 ms, and it was repeated in 16 planes with a 2.50 μm separation in the Z direction. We reconstructed the three-dimensional two-component flow velocity field. From the reconstructed data, the flow velocity field [u_(x,y,z),v_(x,y,z)] in an arbitrary plane can be visualized. The flow rates through YZ and ZX planes were also calculated. During feeding, we examined a suction flow to the mouth of the Vorticella picta and measured it to be to 300 pl∕s.  相似文献   

Early effects of oral administration of omeprazole and roxatidine on intragastric pH     

Iida H  Kato S  Sekino Y  Sakai E  Uchiyama T  Endo H  Hosono K  Sakamoto Y  Fujita K  Yoneda M  Koide T  Takahashi H  Tokoro C  Goto A  Abe Y  Kobayashi N  Kubota K  Gotoh E  Maeda S  Nakajima A  Inamori M 《Journal of Zhejiang University. Science. B》2012,13(1):29-34

Objective

The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H₂-receptor antagonist, roxatidine 75 mg.

Methods

Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period.

Results

During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole (median: 4.45 vs. 2.65; P=0.0367). Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg (median: 90.6% vs. 55.2%, P=0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively).

Conclusions

In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.  相似文献   

Beliefs About Intergenerational Communication Across the Lifespan: Middle Age and the Roles of Age Stereotyping and Respect Norms     

Robert M. McCann  René M. Dailey  Hiroshi Ota 《Communication Studies》2013,64(4):293-311

Guided by theoretical models, this research examines (for the first time within the same design) young American adults' reports of age stereotypes, norms of respect, beliefs about intra‐ and intergenerational communication, and communication satisfaction toward young adult, middle‐aged, and older adult targets. Multivariate analyses showed that as age of target increased so did trait attributions of benevolence, norms of politeness and deference, and communicative respect and satisfaction; however, attributions of personal vitality decreased linearly. Path analyses revealed that the more young adults stereotyped older adults as benevolent and personally vital, the less likely they were to report avoiding communication with them. Deference norms also positively related to the degree of communicative respect afforded older adults and the more respondents reported avoiding communication with them, the less satisfied they were with their intergenerational conversations.  相似文献