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Fengjiao Lyu Manqi Xu Yunfeng Cheng Jinghang Xie Jianghong Rao Sindy K. Y. Tang 《Biomicrofluidics》2015,9(4)
This paper describes a method for the quantitative detection of cells expressing BlaC, a β-lactamase naturally expressed by Mycobacterium tuberculosis, intended for the diagnosis of tuberculosis. The method is based on the compartmentalization of bacteria in picoliter droplets at limiting dilutions such that each drop contains one or no cells. The co-encapsulation of a fluorogenic substrate probe for BlaC allows the quantification of bacteria by enumerating the number of fluorescent drops. Quantification of 10 colony forming units per milliliter is demonstrated. Furthermore, the encapsulation of single cell in drops maintains the specificity of the detection scheme even when the concentration of bacteria that do not express BlaC exceeds that expressing BlaC by one million-fold. 相似文献
33.
He XL Yin HL Wu J Zhang K Liu Y Yuan T Rao HL Li L Yang G Zhang XM 《Journal of Zhejiang University. Science. B》2011,12(1):32-39
Radiation therapy has been widely applied in cancer treatment. However, it often causes thrombocytopenia (deficiency of white
blood cells) as an adverse effect. Recombinant human interleukin-6 (rhIL-6) has been found to be a very effective way against
this thrombocytopenia, but IL-6 has low stability in blood, which reduces its efficacy. To increases the stability and half-life
of rhIL-6, it was modified by polyethylene glycol (PEG). The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled
with 125I were examined after subcutaneous injection in rats. The pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics,
and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption, t
1/2K
a) and 19.77–21.53 h (elimination, t
1/2Ke), and peak concentrations at 20.51–21.96 h (t
peak) in rats. Half-lives and t
peak of PEG-rhIL-6 were longer than those of rhIL-6 previously reported. In the present study, for deposition of PEG-rhIL-6 in
rats, the tissue distribution examination showed that blood was the major organ involved, rather than liver. However, as to
the elimination of PEG-rhIL-6, the major organ was the kidney. The excretion fraction of the injection dose recovered from
urine was 23.32% at 192 h after subcutaneous administration. Less than 6% of PEG-rhIL-6 was eliminated via the feces at 192
h. These results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer. 相似文献
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Science & Education - Like all SSI, the COVID-19 pandemic requires decisions that are contentious, involve scientific thinking, and vary across social groups. This investigation determined how... 相似文献
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加强流动人口中少数民族的思想政治教育,对于构建社会主义和谐社会具有重要而深远的意义。当前流动人口中少数民族子女思想政治教育工作存在很多问题,究其原因主要有宗教思想的根深蒂固、家庭和学校教育的影响等。如何加强少数民族流动人口子女的思想政治教育问题,需要国家、学校、社会以及家庭共同的努力。 相似文献
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管理蜜罐思维是论文作者将网络“蜜罐”思维引入管理科学中，对管理科学进行探讨的一种管理技术。文章通过引入管理蜜罐思维发现农村信息技术应用的问题，记录并预警农村信息技术需求，建设农村信息技术的管理蜜罐动态系统。 相似文献