Thyagaraju K.  Hemavathi B.  Vasundhara K.  Rao A. D.  Devi K. N. 《Journal of Zhejiang University. Science. B》2005,6(8):759-769

A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain and testis after exposure of rat to phenobarbitol (PB) and β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional proteins are involved in intracellular transport processes and in detoxication of electrophilic xenobiotics by catalyzing reactions such as conjugation, isomerization, reduction and thiolysis. On purification, the yield of GST proteins by affinity chromatography was 39% in testis and 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into six anionic and four cationic isozymes, and in brain glutathione transferases were resolved into four anionic and three cationic isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ and Yδ in both of them. In testis and brain, these isozymes at identical pI values showed variable functions with a battery of substrates and the cationic isozymes of brain and testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies and immunoblot analysis of testis and brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis and brain on exposure to PB and MC indicated elevated subunit variation. In both testis and brain, Yδ of π class was expressed on PB treatment and Yc of α class and Yβ of μ class was expressed in MC treated testis and only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinogenesis and specific to chemical toxicity under phenobarbitol and β-methylcholanthrene stress. Project supported by Department of Science and Technology and Council for Scientific and Industrial Research, New Delhi  相似文献   

电流变液阻尼器半主动控制的理论建模     

张华良  饶柱石  傅志方 《上海大学学报(英文版)》2003,7(3):275-279

This paper emphases on analyzing and investigating the mechanical behavior of electro-rheological fluid (ERF) semi-active damper. Theoretical model was developed to describe the relationship between electric field and the resistance force of ERF flowing through two parallel plane electrodes. In the model, the pressure drop along electrodes was supposed to consist of two parts: one related with viscosity and the other related with dynamic yield shear stress. The concept of yield stress influence factor was developed in  相似文献   

Risk factors for coronary heart disease in type II diabetes mellitus     

H. Surekha Rani  G. Madhavi  V. Ramachandra Rao  B. K. Sahay  A. Jyothy 《Indian journal of clinical biochemistry : IJCB》2005,20(2):75-80

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. An attempt has been made to evaluate the risk factors for coronary heart disease in type II diabetics. In the present study the levels of fasting and postprandial plasma glucose, total cholesterol, low density lipoproteins, triglycerides were high and the levels of high density lipoproteins were low in the type II diabetics compared to controls. The markers of free radical induced injury i.e. malondialdehyde and nitrite/nitrate were high while total antioxidant status a marker for antioxidant protection against reactive oxygen species was low in diabetics compared to controls. The study therefore suggests the importance of assessing these markers of oxidative stress and antioxidant capacity along with the other routine investigations in diabetic patients for initiating antioxidant therapy in addition to primary and secondary preventive measures to mitigate the devastating consequences of diabetes leading to coronary heart disease.  相似文献   

“和谐大连”建设中的农产品安全监控与管理     

史兆光  林红霞 《大连大学学报》2009,30(5):98-101

农产品安全是改善民生的重要方面,大连农产品安全仍存在一定隐患,建立农产品安全监管机制非常必要。实现农产品安全监管的路径：加强政府的宏观协调管理,建立统一的监管机制,推行农产品身份证制度,打造驰名品牌,促使全社会关注农产品质量安全,共建和谐大连。  相似文献   

《电路分析与应用》课程教学改革的思路与实施   总被引：3，自引：0，他引：3  

饶蜀华  梁颖  邹涯梅  胡海华 《成都航空职业技术学院学报》2009,25(4):41-43

基于电子信息工程技术专业人才培养目标,结合职业岗位能力要求,本文对"电路分析与应用"课程的教学内容、教学方法与手段的改革进行了探讨,为电子信息工程技术重点专业的改革和建设提供了支撑.  相似文献   

Chemistry of materials     

C. N. R. Rao 《Resonance》2009,14(5):508-517

  相似文献   

大学对区域经济发展的贡献——以加拿大大西洋省区为例     

饶燕婷 《现代教育论丛》2010,(1):30-35

加拿大大西洋省区在历史上是加拿大较为贫困的地区,当地大学通过为地区经济发展提供人才支持和技术支持,并通过各种消费和购买活动推动了地区经济的发展和产业结构的升级,使该地区在较短时间内弥合了与其他经济发达地区的差距。其成功经验在于政府政策的支持、整体的高等教育战略,以及大学与政府和产业界的紧密合作。  相似文献   

青少年网络成瘾、网络偏差行为与一般问题行为的关系     

王莉  邹泓  任磊  么娆 《中国特殊教育》2010,(8)

以北京市370名中学生为被试,采用网络成瘾问卷、网络偏差行为问卷、一般问题行为问卷考查了青少年网络成瘾与网络偏差行为的关系,并探讨了两者对一般问题行为的影响。结果表明：（1）网络成瘾、网络偏差行为存在显著的性别差异,男生得分均显著高于女生;网络偏差行为存在显著的年级差异,初一学生的网络偏差行为最多;（2）网络偏差行为与网络成瘾呈显著正相关;（3）网络成瘾者比非成瘾者表现出更多的一般问题行为;（4）网络偏差行为在网络成瘾与一般问题行为的关系中起到完全中介作用。  相似文献   

Anhydrobiosis     

T. Ramakrishna Rao 《Resonance》2018,23(5):545-553

In aquatic and moist soil environments subjected to periodic drying, a diverse group of organisms (mostly microscopic) have evolved extreme desiccation tolerance through a physiological adaptation called ‘anhydrobiosis’. Notable among such organisms are tardigrades, bdelloid rotifers, and nematodes. Anhydrobiosis also allows these organisms to tolerate extreme temperatures and ionizing radiation. In this article, the signi-cance and some mechanisms of anhydrobiosis are described.  相似文献   

Trophic Cascades     

T Ramakrishna Rao 《Resonance》2018,23(11):1205-1213

In many ecosystems, apex consumers (top predators) play a crucial role in food web dynamics. Their top-down impacts are known to spread downwards through the food webs in a cascading fashion. Trophic cascades manifest when top predators are excluded from an ecosystem or introduced into a system lacking them. Two such case studies are described here. Trophic cascades are generally more pronounced in the aquatic than in the terrestrial ecosystems, which in turn is related to the differences in the average body sizes of herbivores relative to the plant resources they feed upon and in the structure of their food webs. Scientists express concern that human activities have been leading to planet-wide trophic downgrading (loss of apex consumers) which could affect vital ecological processes of the biosphere.  相似文献