Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain     

Lakshmi Lavanya Reddy  Swarup A. V. Shah  Alpa J. Dherai  Chandrashekhar K. Ponde  Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2016,31(1):87-92

Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP.  相似文献   

The high road : Ben Bova. 289 pages,diagrams, 6 × 9 in. Houghton-Mifflin,New York 1981. Price, $11.95.     

I.M. Levitt 《Journal of The Franklin Institute》1982,313(2):120-121

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Realization Theory of Ladder Networks in Terms of the Poles and Zeros of Reflection Coefficient and its Application to a Bandpass Matching Problem     

R. Srinivasagopalan 《Journal of The Franklin Institute》1972

Necessary and sufficient conditions for the realization of lossless, lowpass, ladder networks terminated by a resistance are presented, in terms of the poles and zeros of the reflection coefficient. These conditions yield explicit expressions for the element values. They are then extended to highpass networks. These results are next used in solving a bandpass matching problem and the limitations on the performance of matching networks due to constraints imposed by the load are discussed. A suitable example is worked out to illustrate the problem.  相似文献   

Knowledge management: a neuro-hemispherical view of the field     

Sharif  Amir M 《知识管理研究与实践》2006,4(1):70-72

Knowledge Management Research & Practice - The definition and subsequent use of knowledge within and across organisational and social contexts has been a vibrant and evolving growth area over...  相似文献   

Urinary iodine levels in three ecological zones of Bangladesh     

Salamatullah Quazi  M. Mohiduzzaman  Moududur R. Khan  B. Nahar  M. Mostafizur Rahman  M. Nurul Islam  M. Baquer  Chandrakant S. Pandav  Harun K. M. Yusuf 《Indian journal of clinical biochemistry : IJCB》1997,12(2):128-133

Urinary iodine levels in children (5–11 years) and in adult males and females (15–44 years) of three ecological zones (hilly, flood-prone and plains) of Bangladesh were analyzed to determine the status of biochemical iodine deficiency in the country. Data indicated that a large majority of the population all over Bangladesh have biochemical iodine deficiency urinary iodine excretion (UIE) less than the accepted cut-off level of 10 μg/dl. Adults were deficient to comparable degrees, 31.3% severely iodine deficient. The flood-prone zone was less affected: 71.7% children had iodine deficiency and 25% were severely deficient. Adults of this zone were less affected than the children. Iodine deficiency was least severe in the plain zone: 59.8% children were biochemically iodine deficient and of them 23.4% had UIE less than 2.0 μg/dl. In the case of the adults of this zone, 60.8% were biochemically iodine deficient and 20.6% had severe iodine deficiency. The results indicate that Bangladesh as a whole is an iodine deficient region, with the hilly zone being the most severely affected. Children were slightly more affected than the adults, and females were more affected than the males.  相似文献   

Biotechnology in the Netherlands: controversy or consensus?     

Guttelin JM 《Public understanding of science (Bristol, England)》2002,11(2):131-142

This paper addresses the issue of public perception of modern biotechnology in the Netherlands. Contrary to expectations, data from the 1999 Eurobarometer on biotechnology indicate that the position of the Dutch public in general is rather ambiguous, which is in contrast to many of its neighboring countries. The issue is described in terms of differences between the Netherlands and other European countries on political-economic, social-cultural, or media coverage indicators. On many indicators, the Dutch population differs from that of other European countries, and the Dutch opinion-leading media present a rather balanced perspective on modern biotechnology.  相似文献   

CERN: Past performance and future prospects: II. The scientific performance of the CERN accelerators     

John Irvine  Ben R. Martin 《Research Policy》1984,13(5):247-284

In a series of three papers, we attempt to evaluate the past scientific performance of the three main particle accelerators at the Geneva-based European Organization for Nuclear Research (CERN) over the period since 1960, and to assess the future prospects for CERN and its users during the next ten to fifteen years.We concerned ourselves in a previous paper (Paper 1 - Martin and Irvine [51] with the position of the CERN accelerators in world high-energy physics relative to those at other large laboratories working in the field. We dealt primarily with the period from 1969 to 1978, and attempted to establish how the experimental output from the three principal CERN accelerators, taken as a whole, compared with that from other major facilities. In undertaking this comparative evaluation, we drew on the method of “converging partial indicators” used in previous studies of three Big Science specialties.In contrast, this paper (Paper II) focuses in detail on the scientific performance of each of the CERN accelerators taken individually. In particular, it asks, first, how the outputs from the CERN 28 GeV (giga or billion electron-volts) Proton Synchrotron compare with those from a very similar 33 GeV American accelerator at Brookhaven National Laboratory over the past two decades? Second, how great have been the experimental achievements of the Intersecting Storage Rings in world terms? And, third, how do the outputs from the CERN 400 GeV Super Proton Synchrotron and from a rival American machine at Fermi National Accelerator Laboratory compare? Attempts are then made to identify the main factors responsible for determining the relative scientific performance of each CERN machine.These factors are of relevance to the subject of a third paper (Paper III - Martin and Irvine [52]) which sets out to assess the future prospects for CERN and in particular for LEP, the large electron-positron collider scheduled for completion in the latter part of the 1980s. What are the construction requirements (financial and technical) associated with LEP, and how easily will they be met? How does the scientific potential of LEP compare with that of other major accelerators under construction around the world? And, in the light of the previous record of the CERN accelerators, to what extent is this potential likely to be realized? The paper concludes with a discussion of the extent to which predictive techniques can be utilized in the formulation of scientific priorities, and of the problems in current science policy-making that such techniques might help address.  相似文献   

Prostate specific antigen in patients of benign prostate hypertrophy and carcinoma prostate     

T. Malati  G. Rajani Kumari  P. V. L. N. Murthy  Ch. Ram Reddy  B. Surya Prakash 《Indian journal of clinical biochemistry : IJCB》2006,21(1):34-40

Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the present study PSA was determined in serum of healthy subjects, patients of benign prostate hypertrophy (BPH) and Carcinoma Prostate (Ca−P) to evaluate its diagnostic efficiency in day to day management of prostate cancer patients and in differentiating patients of early prostate cancer from those with BPH. Receiver operating characteristic curve (ROC) revealed 2 ng/ml and 10 ng/ml cut off serum PSA level for BPH and untreated carcinoma prostate patients (Ca−P). An extremely significant increase (P<0.0001) was observed in mean PSA concentration in BPH patients and adenocarcinoma prostate patients when compared to healthy males. Clinical relevance of PSA was highlighted by a case study of cancer patient prior to any therapy till death.  相似文献   

Secondary immunization inhibits drug induced apoptosis<Emphasis Type="Italic">in vivo</Emphasis>     

Winston Costa Pereira  Muddanna S. Rao  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):161-168

Immunization with a proper dose of an antigenic stimulus leads to cell proliferation and antibody response of circulating lymphocytes. We have previously observed that Secondary immunized spleenocytes resist ceramide-mediated apoptosisin vitro. Our present study is aimed at investigating thein vivo effect of immunization on apoptosis. Mice were subjected to either Primary or Secondary dose with Tetanus Toxoid. Unimmunized spleenocytes served as controls. Unimmunized, Primary and Secondary immunized mice were later exposed to chemotherapeutic drugs such as Etoposide/Methotrexate/Vincristine to induce apoptosis. Apoptosis was studied by using the Feulgen reaction on 5μ thin parafin sections of spleen. It was observed that Secondary immunized mice showed a lower percentage of apoptosis as compared to Primary or Unimmunized mice that was subjected to either of the chemotherapeutic drugs. It was thus concluded that Secondary immunization inhibits the process of chemotherapeutic drug induced apoptosis in vivo.  相似文献   

Analyzing imbalance among homogeneous index servers in a web search system     

C.S. Badue  R. Baeza-Yates  B. Ribeiro-Neto  A. Ziviani  N. Ziviani 《Information processing & management》2007

The performance of parallel query processing in a cluster of index servers is crucial for modern web search systems. In such a scenario, the response time basically depends on the execution time of the slowest server to generate a partial ranked answer. Previous approaches investigate performance issues in this context using simulation, analytical modeling, experimentation, or a combination of them. Nevertheless, these approaches simply assume balanced execution times among homogeneous servers (by uniformly distributing the document collection among them, for instance)—a scenario that we did not observe in our experimentation. On the contrary, we found that even with a balanced distribution of the document collection among index servers, correlations between the frequency of a term in the query log and the size of its corresponding inverted list lead to imbalances in query execution times at these same servers, because these correlations affect disk caching behavior. Further, the relative sizes of the main memory at each server (with regard to disk space usage) and the number of servers participating in the parallel query processing also affect imbalance of local query execution times. These are relevant findings that have not been reported before and that, we understand, are of interest to the research community.  相似文献