Role of HAMP Genetic Variants on Pathophysiology of Iron Deficiency Anemia     

S. Pandey  S. K. Pandey  V. Shah 《Indian journal of clinical biochemistry : IJCB》2018,33(4):479-482

Hepcidin is a 25-amino acid peptide hormone produced by hepatocytes and plays a key role in body iron metabolism. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemia, and its excess is associated with anemia of inflammation, chronic disease and iron deficiency anemia (IDA). The aims of this study was to evaluate HAMP gene mutation, namely IVS2 + 1(–G) (c.148–150 + 1del) and Gly71 Asp (c.212G > A (rs104894696) association with iron status in IDA conditions. Our study participants were 500 IDA patients and 550 age and sex-matched healthy controls. Hepcidin, ferritin and CRP analysis was done by ELISA method while ESR analysis was done according to Wintrobe method. CBC analysis was done by auto-analyzer. Two mutations in the HAMP genes were analysed by PCR RFLP method. Among the IDA patients, 7 were heterozygous for Met50del IVS2 + 1(–G) mutation. Nine IDA patients were heterozygous for G71D G–A mutation and homozygous were not identified in both mutations.Controls were showing heterozygous frequency 1.8 and 2.1% of Met50del IVS2 + 1(–G) and G71D G–A mutations respectively. Mutation of HAMP (Met50del IVS2 + 1(–G) and G71D G–A) were clinically associated with IDA and act as modulator of disease.  相似文献   

Effect of contact and no-contact small-sided games on elite handball players     

Antonio Dello Iacono  Domenico Martone  Alessandro Moura Zagatto  Yoav Meckel  Mahmood Sindiani  Mirjana Milic 《Journal of sports sciences》2018,36(1):14-22

This study aimed to investigate the effect of contact (C-SSG) and no-contact (NC-SSG) handball small-sided games (SSGs) on motion patterns and physiological responses of elite handball players. Twelve male handball players performed 10 C-SSG and 10 NC-SSG while being monitored through the heart rate (HR) and rate of perceived exertion (RPE) as physiological responses and time-motion activities profile using video-match analysis. Both game conditions resulted in similar HR responses (P > 0.05), but the NC-SSG led to a higher RPE scores. The time-motion activity analysis featured NC-SSG with a greater amount of walking (855.6 ± 25.1 vs. 690.6 ± 35.2 m) and backward movements (187.5 ± 12.3 vs. 142.5 ± 8.7 m) combined with fast running (232.3 ± 8.5 vs. 159.7 ± 5.7 m) and sprinting (79.5 ± 4.7 vs. 39.7 ± 3.7 m) activities (P < 0.001). Conversely, C-SSG had a higher percentage of jogging and sideway movements associated with greater frequency of jumping (0.87 ± 0.09 vs. 0.31 ± 0.06 nr) and physical contact (1.82 ± 0.55 vs. 0.25 ± 0.03 nr) events (P < 0.001). No between-regimen differences were found for the number of throws (P = 0.745). In addition, the RPE was significantly correlated with fast running relative distances (r = 0.909, P < 0.001) and sprinting relative distances (r = 0.939, P < 0.001). In conclusion, this investigation showed that both C-SSG and NC-SSG in team handball can effectively represent specifically oriented exercises, according to the sport-task and the performance demands.  相似文献   

Trends in private higher education in Australia     

Mahsood Shah  Hai Yen Vu  Sue-Ann Stanford 《Perspectives: Policy and Practice in Higher Education》2019,23(1):5-11

The last decade has witnessed a significant growth of private higher education around the world. The growth included the number of private education providers, and also the growing number of students. While some countries are experiencing trend growth, others are witnessing decline. Some of the reasons for the decline include increased regulation and stringent accreditation and reaccreditation of higher education institutions and courses, government policies to encourage the growth of public universities, and acquisition of small providers by large private education institutions. The growth of private higher education has increased competition, and it has also established collaboration with public institutions. The growth of private higher education has also raised concerns about ethical governance, maintenance of academic standards, and mechanisms to plan, review, and improve educational outcomes. This paper focuses on Australia where despite growth, there is limited research about private higher education. This paper reviews literature on the global growth and decline of private higher education. It then analyses the trends in Australia and possible scenarios for the future of private higher education in the country.  相似文献   

Equal Opportunity Issues in the Context of the National Curriculum: a black perspective     

Sneh Shah 《Gender and education》1990,2(3):309-318

This article examines the context and content of the National Curriculum documentation published so far within the framework of educational debates on the education of black children (black referring to non‐white). In particular it focuses on the interpretation of equal opportunities, the proposed strategies for implementation within the National Curriculum, and the prospects for success because of the other changes brought about by the 1988 Education Reform Act (ERA). The main conclusion is that in some respects more appears to have been achieved than would have seemed possible in the early stages of the debates relating to ERA; on the other hand, there is a probability that an education system that provides true equal opportunities for groups and individuals currently being denied that will remain more of a hope than a reality. The article concludes that equality of opportunity is still a long way off, especially from a black perspective.  相似文献   

Goodbye conflict, hello development? Curriculum reform in Timor-Leste     

Ritesh Shah 《International Journal of Educational Development》2012,32(1):31-38

Motivations to reform curriculum in post-conflict, or post-colonial states are often driven by the need to (re) construct a cohesive and publicly legitimated national identity that is starkly different to that which existed prior. This paper explores the context behind such action in the Timor-Leste (East Timor) and some challenges which policy makers and citizens have wrestled with in developing and implementing the country's first post-independence primary curriculum. The author argues that specific aspects of this new curriculum have effectively alienated and/or divided large segments of its population, despite a desire for the reforms to result in a more inclusive, democratic and distinctly “Timorese” educational system. The assertion is that the desire to institute change rapidly after independence has in fact hampered the ability of the reforms to constructively serve the political and social project of nation building. The paper cautions that education's role in promoting human development, and reducing the triggers of conflict in this country hang in the balance as long as this new curriculum fails to deliver on its aspirations.  相似文献   

Jordanian School Counselor Involvement in School-Family-Community Partnerships     

Souad Mansour Ghaith  Suhaila Mahmood Banat  Ghada Esmail Hamad  Ghaleb Salman Albadareen 《International journal for the advancement of counseling》2012,34(4):307-319

The purpose of this study was to identify the level of partnership between the school counselor, families and the local community in Jordan, as well as highlighting the factors that affect this partnership. A “School Counselor Involvement in School-Family-Community Partnerships Scale” was developed and administered to a sample of 152 school counselors in order to measure the level of such partnerships. The results indicated that the school counselors’ involvement was more prominent in providing services and information for students and parents, and coordinating efforts to raise the academic level of students. The results revealed that counselors’ attitudes, self-esteem, and school climate represented the most salient factors that affected school-family-community partnerships. Findings also recognized barriers to counselors’ involvement, including communication with parents and lacking the necessary skills. Based on the findings, it seems that Jordanian school counselors need training and efforts to overcome barriers related to partnership behaviors.  相似文献   

A visual demonstration of the sample median     

Munir Mahmood 《Teaching Statistics》2012,34(3):112-112

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Intensity of parasitic infestation in silver carp, Hypophthalmichthys molitrix     

M. M. Alam  M. A. Khan  M. A. Hussain  D. Moumita  A. G. Mazlan  K. D. Simon 《Journal of Zhejiang University. Science. B》2012,13(12):1024-1028

Silver carp, Hypopthalmichthys molitrix is one of the most economically valuable fish species in Bangladesh. However, its production is often hindered by parasite-induced mortality. The present study reports the intensity of parasitic infestation in 216 specimens of H. molitrix collected from different fish markets in Rajshahi City, Bangladesh. Nine different parasite species (Trichodina pediculatus, Dactylogyrus vastator, Ichthyophthirius multifilis, Gyrodactylus elegans, Lernaea sp., Apiosoma sp., Myxobolus rohitae, Camallanus ophiocephali, and Pallisentis ophiocephali) were recovered from the gill, skin, stomach, and intestine of host fish. The highest level of infection was observed for host skin, while lower levels were observed for host gill, stomach, and intestine. The results also revealed that the intensity of parasite infection in different organs of H. molitrix varied with the season. In particular, the highest levels of infection were recorded during the winter period (November-February), when fish are most susceptible to parasites. The findings of the study will help in the management and conservation of H. molitrix.  相似文献   

US news magazine images of black‐Asian American relationships, 1980–1992     

Michael C. Thornton  Hemant Shah 《The Communication Review》2013,16(4):497-519

During the past 20 years, primarily Latinos and Asians have immigranted to these shores and settled in urban areas. Media sources assert that this influx created particularly problematic relations between blacks and Asian Americans. Using Frame theory and textual analysis, we explored the images newsmagazines produced of this relationship. We found that one frame predominated: the nature of group relations had to do with each group's “essential”; qualities. Within this frame there also appeared four media packages: 1) the nature of the urban space, 2) the role of culture in the quality of relationships, 3) the essential qualities of urban residents and 4) the preeminence of class over race. Analysis of black‐Asian American relationships, while not strictly hegemonic, rarely deviated from accepted critiques. The nature of the coverage constrained understanding to personal shortcomings, while poverty and racial strife were rarely associated with historical and structural factors.  相似文献   

The Impact of Quality on Satisfaction,Revenue, and Cost as Perceived by Providers of Higher Education     

Abhay Shah 《Journal of Marketing for HIGHER EDUCATION》2013,23(2):125-141

Researchers have found a strong relationship between improvements in quality and satisfaction, revenue, and cost. However, no study to date investigates the same for higher education. This study investigates whether institutions of higher education have implemented quality improvement programs, and if so, if the results are similar to what has been observed with firms in the private sector. The study proposes and tests five hypotheses, and findings support four of the five hypotheses, with partial support for the fifth hypothesis. The study finds that implementing quality programs leads to an increase in satisfaction among constituent groups, increase in revenue, and a reduction in costs. The findings also show that increased satisfaction (due to improved quality) also leads to increase in revenue and reduction in costs.  相似文献