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Objective:

This paper examines the development and evaluation of an automatic summarization system in the domain of molecular genetics. The system is a potential component of an advanced biomedical information management application called Semantic MEDLINE and could assist librarians in developing secondary databases of genetic information extracted from the primary literature.

Methods:

An existing summarization system was modified for identifying biomedical text relevant to the genetic etiology of disease. The summarization system was evaluated on the task of identifying data describing genes associated with bladder cancer in MEDLINE citations. A gold standard was produced using records from Genetics Home Reference and Online Mendelian Inheritance in Man. Genes in text found by the system were compared to the gold standard. Recall, precision, and F-measure were calculated.

Results:

The system achieved recall of 46%, and precision of 88% (F-measure = 0.61) by taking Gene References into Function (GeneRIFs) into account.

Conclusion:

The new summarization schema for genetic etiology has potential as a component in Semantic MEDLINE to support the work of data curators.

Highlights

  • Semantic MEDLINE streamlines information retrieval by succinctly expressing the meaning of sometimes complicated text and summarizing output according to a user''s needs.
  • Semantic MEDLINE identifies genes noted in biomedical text as associated with a disease process.
  • Semantic MEDLINE can potentially simplify secondary database curation.

Implications

  • Library information retrieval services can potentially benefit from automated applications such as Semantic MEDLINE.
  • Use of such automated applications can facilitate the library''s work in interdepartmental collaborative endeavors, thus reinforcing the library''s core value in its parent institution.
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Knowledge Management Research & Practice - Information and knowledge have been cited over the last two decades as competitive advantage tools. Recently, the use of them has been discussed to...  相似文献   
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Signal constellations in the hyperbolic plane are provided as an alternative to traditional signal constellations in the Euclidean plane, since channels may actually exist for which the latter signal constellations are not as suitable as the former. A hyperbolic gaussian probability density function, based solely on geometrical considerations, is derived to determine the performance of the hyperbolic signal constellations. Benefits result from an approach conceived in terms of reduced signal-to-noise ratio, needed to achieve a prescribed error rate and equivalent optimum receiver complexity.  相似文献   
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Heavy metals are important toxicants known to exert adverse effects in humans and animals, given sufficient exposure and accumulation in the body. This has a great concern both at personal and public health risk. Heavy metals are also known to interact with the essential trace minerals at the level of absorption and also during the metabolism. The adverse effects of the absorbed and accumulated heavy metals include neurological, reproductive, renal and hematological systems. Children are more sensitive than adults to the effects of lead. Efforts are made to understand the mechanism of the interactions of heavy metals with essential trace minerals at the level of absorption. With available sensitive and specific methodologies like Anodic Stripping Voltammetry for the evaluation of the levels of toxic heavy metals such as lead, cadmium, mercury etc., better understanding of heavy metal absorption is made possible. Due to the poor nutritional standards, risk of heavy metal exposure is still a major concern in developing countries. Studies carried out by the author have provided evidence towards the understanding of the prevailing mechanisms of metal-metal interaction at the intestinal level. During growth and development the demand for the essential minerals being at higher level, differentiation of various essential metals and heavy metals pose an inherent problem due to certain common properties shared by them. With this approach to the problem of heavy metal toxicity, it is preventable not only with environmental intervention but also by the nutritional management.  相似文献   
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Governments worldwide are encouraging public agencies to join e-Government initiatives in order to provide better services to their citizens and businesses; hence, methods of evaluating the readiness of individual public agencies to execute specific e-Government programs and directives are a key ingredient in the successful expansion of e-Government. To satisfy this need, a model called the eGovernment Maturity Model (eGov-MM) was developed, integrating the assessment of technological, organizational, operational, and human capital capabilities, under a multi-dimensional, holistic, and evolutionary approach. The model is strongly supported by international best practices, and provides tuning mechanisms to enable its alignment with nation-wide directives on e-Government. This article describes how the model was conceived, designed, developed, field tested by expert public officials from several government agencies, and finally applied to a selection of 30 public agencies in Chile, generating the first formal measurements, assessments, and rankings of their readiness for e-Government. The implementation of the model also provided several recommendations to policymakers at the national and agency levels.  相似文献   
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This article presents a case study on the political thought and citizenship conceptions of children and adolescents. Considering children and adolescents as reflexive citizens and partners in community development processes, it is our purpose to understand the development of political thought, and particularly how children conceive the exercise of citizenship and participation. Participants were 97 children of a primary and middle secondary (basic) school, aged 5 to 14?years, organized into age groups of 12 children each. Focus group discussions were used as participatory research methodology which involves children as active collaborators, a method that appears to be a good alternative to the traditional individual interviews used in previous research. Results point to the existence of a developmental process of political thought that begins before the start of formal schooling, and a parallel evolution of the conception of social organization and the concepts of citizenship and participation.  相似文献   
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