Cytotoxicity and Apoptosis Inducing Activities of 2-Amino-4H-chromene-3-carbonitrile Derivatives Loaded on Gold Nanoparticles Against Human Breast Cancer Cell Line T47D     

Zahra Saffari  Maryam Farahnak Zarabi  Hasan Aryapour  Alireza Foroumadi  Ali Farhangi  Soheil Ghassemi  Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2015,30(2):140-149

Chemotherapy drugs, used for prevention of uncontrolled cell proliferation in certain tissues as well as inducing apoptosis in tumor cells, are important candidates for treatment of cancer. The synthesized 2-amino-4H-chromene-3-carbonitrile derivatives effective on cancerous cells resistant to other drugs such as Paclitaxel were used due to their ability in induction of apoptosis. The growth inhibitory and inducing apoptosis activities were determined. In order to make it target-oriented, the best compound was conjugated with gold nanoparticles (NPs) by aspartic acid with chemical reduction method. Cytotoxicity effect of 2-amino-4H-chromene-3-carbonitrile derivatives against the T47D breast cancer cell line was determined by MTT assay. The synthesis of gold NPs was confirmed by transmission electron microscopy, UV–Vis and dynamic light scattering. To assess the effects of compounds on the process of apoptosis, staining methods with acridine orange–ethidium bromide and Hoechst staining by fluorescence microscopy and DNA fragmentation by the diphenylamine method were used. The synthesized compounds containing two NH₂ groups on benzene rings, demonstrated more cytotoxicity effect. The effect of conjugation with gold NPs and the induction of apoptosis were studied with the best compound. The cytotoxicity effects of the synthesized 2-amino-4H-chromene-3-carbonitrile compounds were changed by replacement of NO₂ group on thiol ring with different chemical groups on the benzene ring. Analyses of treated cell lines by conjugated and non-conjugated forms of compounds verified their ability in inducing apoptosis while conjugated form demonstrated higher apoptosis.  相似文献   

What is the meaning of spiritual health among older adults? A concept analysis     

Hosein Ajam Zibad  Mahshid Foroughan  Hassan Rafiey  Maryam Rassouli 《Educational gerontology》2013,39(12):795-808

ABSTRACT

The different dimensions of spiritual health among older adults remain unknown to date and no globally acceptable definitions have yet been provided for the concept. To conduct the current study, the databases including Proquest, Medline, CINAHL, Science Direct, Blackwell, Iranmedex, SID, Noor Magazine and Irandoc were searched for the articles published between 1980 and 2014 in both English and Persian using keywords including spirituality, spiritual well-being, spiritual health, geriatric, older adult and old people and their Persian equivalents. The search for articles yielded into 197 titles, 31 of which were repeated and were therefore excluded. The remaining 166 articles were screened based on the inclusion criteria. A total of 29 articles were ultimately selected as the study samples. Rodgers’ evolutionary approach to concept analysis is used to identify the attributes, antecedents, consequences and surrogate terms of “spiritual health” and to provide a more comprehensive definition of the concept. The results obtained showed that spiritual health from the perspective of older adults is a multi-dimensional concept with cognitive, functional, affective and consequential components. Each component was found to be composed of several indicators. The results may help in providing a more thorough definition of spiritual health which can be a solid base for future researchers to develop appropriate tools for the assessment of older adults’ spiritual health and encourage research into this partially neglected subject. Care providers may also benefit from the results through acquiring a better understanding of the concept which can be used in designing appropriate spiritual interventions.  相似文献   

Optimal adaptive reset control with guaranteed transient and steady state tracking error bounds     

Mehrnoush Davanipour  Alireza Khayatian  Maryam Dehghani 《Journal of The Franklin Institute》2017,354(14):5949-5963

In this paper, a solution for improvement of transient performance in adaptive control of nonlinear systems is proposed. An optimal adaptive controller based on a reset mechanism and a prescribed performance bound is devised. The suggested controller has the structure of adaptive backstepping controller in which the estimated parameters are reset to an optimal value. The designed controller ensures both the transient bound and the asymptotical convergence of the states. It is shown that the tracking error satisfies the prescribed performance bound all the time, besides the speed of the convergence rate is increased by resetting the estimated parameters. The results have been proved through both the analytical and simulation studies. The proposed method is applied to an Augmented Quarter Car Model as a case study. Simulation results verify the established theoretical consequences that the prescribed performance bound based optimal adaptive reset controller can enhance the transient performance of the adaptive controller.  相似文献   

Lead White or Lead Whites? Reconsideration of Methods of sefidāb-i-sorb Production in Iran     

Maryam Niknejad 《文物保护研究》2019,64(1):1-9

Lead white is widely used as a white pigment in the history of Persian painting. This paper focuses on three Persian treatises dated between the twelfth and the sixteenth century, which explained different manufacturing methods of lead white or sefidāb-i-sorb. Experimental reconstruction of each recipe to access the comprehensive meaning of the text and analytical studies with X-ray powder diffraction on products of recipes revealed white compounds other than the previously known products of hydrocerussite (Pb(OH)₂?·?PbCO₃) and cerussite (PbCO₃) in samples. Chlorine-containing raw materials mentioned in these recipes lead to the chemical products of laurionite (Pb(OH)Cl), blixite (Pb₈O₅(OH)₂Cl₄), and phosgenite (Pb₂Cl₂(CO)₃) in the final products. These data lead to the hypothesis of the discrepancy of the lead white pigment between Iran and Europe and a marked probability of other compounds in historic Persian lead white samples.  相似文献