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The growing field of miniaturized diagnostics is hindered by a lack of pre-analysis treatments that are capable of processing small sample volumes for the detection of low concentration analytes in a high-throughput manner. This letter presents a novel, highly efficient method for the extraction of low-molecular weight (LMW) proteins from biological fluids, represented by a mixture of standard proteins, using integrated microfluidic systems. We bound a polydimethylsiloxane layer patterned with a microfluidic channel onto a well-defined nanoporous silica substrate. Using rapid, pressure-driven fractionation steps, this system utilizes the size-exclusion properties of the silica nanopores to remove high molecular weight proteins while simultaneously isolating and enriching LMW proteins present in the biological sample. The introduction of the microfluidic component offers important advantages such as high reproducibility, a simple user interface, controlled environment, the ability to process small sample volumes, and precise quantification. This solution streamlines high-throughput proteomics research on many fronts and may find broad acceptance and application in clinical diagnostics and point of care detection. 相似文献
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The relationship between anagram solving and reading aloud proficiency was studied in Italian and French 6th grade children. Whereas a statistically significant relation was found in Italian, the link was not so direct in French. French children's ability in solving anagram problems seemed to benefit from their capacity in recognising written word-forms (lexical decision) and using the direct lexical reading route. Statistical properties concerning lexical entries appeared to be in an intermediate stage of computation. It is thus concluded that anagram solving may highlight some developmental stages and processing strategies in the acquisition and elaboration of written language. 相似文献
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ABSTRACT The article focuses on social vulnerability and how Lifelong Learning (LLL) policies tackle it. Two Italian case studies on local LLL measures within Italian Youth Guarantee (YG) scheme are discussed: Civic Service in Genoa and NEETwork Project in Milan. The aim is to investigate how such measures shape the life courses of young adults in vulnerable conditions. Examining whether their support of the school–work transitions meets the youths’ needs, accounting for the different contexts and the individual resources and shortcomings. Similarities and differences between the two case studies are discussed, focusing on policies’ governance and concept of vulnerability applied to young adults. A conceptualisation of the vulnerability as a process developing over the young adults’ life course trajectories is presented. Conceiving it in a multidimensional way, discussing the interplay between the individual resources, and contextual factors in emerging ‘vulnerable conditions’ of young adults. Then, the article proposes possible interpretations of the ways in which young adults relate to and cope with LLL policies, according to the Merton’s strain theory, outlining different strategies of adaptation in uncertain biographies. The risk to increase social exclusion and inequalities is discussed as an unintended effect of LLL policies. 相似文献
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Mauro Lombardi 《Research Policy》2003,32(8):1443-1462
The aim of this paper is to propose an explanation of the changes of dynamic matching between systemic properties of local production systems (LPS) and characteristics of the competitive environment. An evolutionary sequence travelled during the last three decades by Italian LPS is identified and an explanation of long-term dynamics is based on how information flows and knowledge are structured within a local environment. The “traditional” pattern of interlocking behaviours of different agents is defined as cognitive architecture, which evolutionarily emerges as invisible mind. Evolutionary pressures lead new patterns of relationships and interlocking behaviours, which we define as a tendency for more visible “minds” to assert themselves. 相似文献
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Mauro Guazzo 《Information processing & management》1977,13(3):155-165
This paper challenges the meaningfulness of precision and recall values as a measure of performance of a retrieval system. Instead, it advocates the use of a normalised form of Shannon's functions (entropy and mutual information). Shannon's four axioms are replaced by an equivalent set of five axioms which are more readily shown to be pertinent to document retrieval.The applicability of these axioms and the conceptual and operational advantages of Shannon's functions are the central points of the work.The applicability of the results to any automatic classification is also outlined. 相似文献
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Alexander Nicolaides Nathan Elliott John Kelley Mauro Pinaffo Tom Allen 《Sports Engineering》2013,16(3):181-188
Topspin has become a vital component of modern day tennis. Ball-to-string bed and inter-string friction coefficients can affect topspin generation from a racket. The aim of this research was to determine the effect of string bed pattern on topspin generation. Tennis balls were projected onto nine head-clamped rackets with different string bed patterns. The balls were fired at 24 m/s, at an angle of 26° to the string bed normal with a backspin rate of 218 rad/s and outbound velocity, spin and angle were measured. Outbound velocity was shown to be independent of string bed pattern. Outbound angle increased with the number of cross strings, while outbound topspin decreased. In the most extreme case, decreasing the number of cross strings from 19 to 13 increased rebound topspin from 117 to 170 rad/s. 相似文献
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This article discusses the changes that are occurring in the world of cataloging. It argues that these changes need to be coordinated. It also discusses the feature of current OPACs, FRBR, the Paris Principles and its proposed replacement (ICP), AACR2 and its proposed replacement (RDA), ISBD, and the relationships between and among these standards. It argues that the syntax of ISBD is an essential component of RDA and all future international and national cataloging codes. 相似文献
19.
Mauro P. Porto 《The Communication Review》2013,16(4):433-459
Brazilian telenovelas (soap operas) have been playing a growing and important role in the discussion of political and social problems in Brazil. This specific role of melodrama in Brazilian culture imposes the necessity of exploring its influence upon the political process, avoiding the prejudice and indifference of the traditional approach to this problem on the part of political scientists. The objective of this article is to stress the importance of telenovelas for the interpretation of the Brazilian political process and to show their role as a key public forum in the discussion of political and social issues. A content analysis of three telenovelas that preceded the 1994 Brazilian presidential election is developed to identify the constitutive elements of the “scenario of representation of politics” (SR‐P) within which the electoral process took place. The identification of the SR‐P's constitutive elements is made on the basis of three telenovelas produced by TV Globo: Renascer (Revival), Fera Ferida (Wounded Beast) and Pátria Minha (My Homeland). The implications of the study for the analysis of political and electoral processes are discussed. 相似文献
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José Cazuza de Farias Júnior Alex Antonio Florindo Maria Paula Santos Jorge Mota Mauro V. G. Barros 《Journal of sports sciences》2013,31(10):963-973
AbstractThis study aimed to investigate the direct and indirect associations between perceived environmental characteristics and psychosocial factors and physical activity levels in adolescents from Northeast Brazil. The sample was composed of 2,361 adolescents aged 14–19 years (56.6% female). Physical activity was measured using a questionnaire and environmental (perceived environmental characteristics) and psychosocial (self-efficacy, social support from parents and friends for physical activity) factors with previously validated scales. Perceived environmental characteristics were not directly associated with the levels of physical activity, but exhibited significant indirect associations, mediated by self-efficacy in males. Self-efficacy and social support were positively and directly associated with physical activity levels, and part of the associations between social support and physical activity was mediated by self-efficacy. Perception of self-efficacy and social support, important factors associated with physical activity levels in adolescents, should be the target of interventions aimed at increasing physical activity. Favorable environments for physical activity also need to be considered, since they have a positive influence on the self-efficacy of adolescents. 相似文献