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21.
K. Sri Manjari Pratibha Nallari A. Vidyasagar A. Jyothy A. Venkateshwari 《Indian journal of clinical biochemistry : IJCB》2012,27(2):152-156
Chronic pancreatitis (CP) presenting clinically with upper abdominal pain, as well as exocrine and endocrine insufficiencies, is characterized by irreversible morphological and functional alterations in the pancreas. The objective of the present study is to investigate the plasma levels of transforming growth factor-β 1 (TGF-β1), matrix metalloproteinases MMP-1 (collagenase) and MMP-3 (stromelysin) in CP. A total of 71 CP patients and 100 control subjects were considered for the study. Plasma levels of TGF-β1, MMP-1 and MMP-3 were determined by enzyme-linked immunosorbent assay in patients and control subjects. The plasma levels of TGF-β1 and MMP-1 were significantly elevated in patients compared to control group (*P = 0.0301, **P < 0.0001). However, there was no significant difference in the plasma levels of MMP-3 between patients and controls (P = 0.3756). The elevated levels of TGF-β1 and MMP-1 may influence the inflammatory reactions by enhancing the pancreatic stellate cell activation and deposition of extracellular matrix resulting in pancreatic fibrosis. Thus, the present study highlights the role of fibrogenic cytokine marker TGF-β1 and matrix metalloproteinases in the pathogenesis of CP. 相似文献
22.
Pratibha Mehta Luthra Rambir Singh Ramesh Chandra 《Indian journal of clinical biochemistry : IJCB》2001,16(2):153-160
Curcuma longa commonly known as tumeric is traditionally used as a spice in Indian food. A wide range of biological activities e.g. anticancer,
antimicrobial, antiinflammatory and free radical scavenging activity of the plant suggests a logical basis for its traditional
use in foodstuff. Various phytothreapeutic uses ofCurcuma longa have been reviewed. 相似文献
23.
Rashmi Raghuvanshi Aiki Kaul Pushpa Bhakuni Aparna Mishra M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2007,22(2):90-92
In the present communication, we report remarkably elevated levels of xanthine oxidase activity in the blood of the patients
with myocardial infarction when compared to age and sex matched healthy persons. Highly significant increase of malondialdehyde,
serving as an index of lipid peroxidation and thus free radical mediated damage, has also been found in the patients. We propose
the measurement of the blood levels of xanthine oxidase, a very simple, reliable and less time consuming method as an indicator
of myocardial infarction. 相似文献
24.
Richard L. Peterson Mark L. Berenson Ram B. Misra David J. Radosevich 《Decision Sciences Journal of Innovative Education》2008,6(2):375-402
Student faculty ratings are used at most institutions of higher learning for three important reasons. First, the ratings provide direct feedback to the faculty, and this enables faculty to adjust their teaching styles. Second, the ratings provide the administration with information intended to assist in guiding and mentoring faculty toward more effective pedagogical performance in the classroom. Third, the ratings also provide the administration with information to be used in the reappointment, tenure, and promotion processes, as well as for assignment of salary range adjustments and teaching awards. To be of real value, however, all of this is predicated on the use of a valid and reliable faculty‐rating instrument along with a system designed to provide both the faculty and the administration with norming reports that allow for appropriate comparisons of ratings. This article reports such a study conducted within a large department of a business school and recommends that the process used be adapted by other business school departments and other academic units across the university and at other universities to ensure a more universally appropriate usage of students’ ratings. 相似文献
25.
T. K. Saha Arabinda Mohan Bhattarai H. S. Batra Mithu Banerjee Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2015,30(3):271-274
Increase in urine albumin excretion rate (AER) precede a fall in glomerular
filtration rate in patients developing diabetic chronic kidney disease (CKD). Our
results have shown that 7 (50 %) of diabetic and hypertensive individuals with
decreased GFR do not have increased AER. In this cross-sectional study, we measured
AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric
method. We correlated the results with eGFR values obtained by Cockcroft–Gault and
MDRD method. The method used was not a compensated method. We measured serum
creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of
data showed positive correlation between eGFR and microalbuminuria by both the
methods with eGFR <60 mL/min/1.73 m2. Pearson’s
correlation co-efficient (r) was 0.9 (p = 0.0001)
by Cockcroft–Gault formula and 0.69 (p = 0.0063)
by MDRD formula. Our results concluded that there was positive correlation between
AER and eGFR <60 mL/min/1.73 m2. We have recognized
that these two parameters provide a complimentary benefit in management of cases
with CKD. 相似文献
26.
M. Chandra D. R. Maurya S. Kumar H. Basara A. Ghatak B. L. Tekwani G. Kaur M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2003,18(2):150-153
Despite enormous research in the field of hypertension, its pathophysiology still remains largely unresolved and appears to
be multifactorial. In the present communication, we have analyzed the status of nitric oxide (NO) in the patients with essential
hypertension and age matched controls. We have found that the levels of NO are lowered in essential hypertension. The normalization
of blood pressure by administration of antihypertensive therapy causes rise in the NO level indicating that perturbed NO status
in essential hypertension is reversible. Addition of antioxidant to the antihypertensive drugs causes a further, though non
significant, rise in the levels of NO, suggesting that antioxidants may be combined with antihypertensive drugs as adjunct
in the management of essential hypertension. 相似文献
27.
Pratima Tripathi M. K. Misra Shivani Pandey 《Indian journal of clinical biochemistry : IJCB》2012,27(3):296-299
Oxidative stress conditions associated with atherosclerosis leads to oxidative modification of low-density lipoprotein (LDL). The body’s capabilities to inhibit LDL oxidation and to remove or neutralize the atherogenic oxidized LDL (ox-LDL) are limited. When the LDL cholesterol level increases in the blood, it leads to dangerous consequences like atherosclerosis, leading to myocardial infarction. The major effect of an antioxidant in the LDL environment is to prevent the formation of ox-LDL (during atherogenesis. Strategies to reduce LDL oxidation and prevent atherogenesis can involve the enrichment of arterial cells with potent antioxidants that can prevent oxidative damage to the arterial wall. The objective of this study is to evaluate the effect of l-arginine on serum lipid and cholesterol levels in the patients of acute myocardial infarction (AMI). The study consisted of 70 AMI patients and 60 healthy individuals (serving as control) age 55–65 years. Serum levels of total cholesterol, high density lipoprotein (HDL), LDL and Triglycerides were determined on day 1 and day 15 of l-arginine administration (oral dose 3 g/day). The total cholesterol/HDL and the LDL/HDL ratio were calculated and compared. As per the observations, l-arginine administration was found to improve the lipid profile of the subjects. Hence it could be used as an adjuvant therapy for AMI and as a preventive measure for the onset of the disease in the healthy elderly also. 相似文献
28.
Lisa Corwin Auchincloss Sandra L. Laursen Janet L. Branchaw Kevin Eagan Mark Graham David I. Hanauer Gwendolyn Lawrie Colleen M. McLinn Nancy Pelaez Susan Rowland Marcy Towns Nancy M. Trautmann Pratibha Varma-Nelson Timothy J. Weston Erin L. Dolan 《CBE life sciences education》2014,13(1):29-40
The Course-Based Undergraduate Research Experiences Network (CUREnet) was initiated in 2012 with funding from the National Science Foundation program for Research Coordination Networks in Undergraduate Biology Education. CUREnet aims to address topics, problems, and opportunities inherent to integrating research experiences into undergraduate courses. During CUREnet meetings and discussions, it became apparent that there is need for a clear definition of what constitutes a CURE and systematic exploration of what makes CUREs meaningful in terms of student learning. Thus, we assembled a small working group of people with expertise in CURE instruction and assessment to: 1) draft an operational definition of a CURE, with the aim of defining what makes a laboratory course or project a “research experience”; 2) summarize research on CUREs, as well as findings from studies of undergraduate research internships that would be useful for thinking about how students are influenced by participating in CUREs; and 3) identify areas of greatest need with respect to CURE assessment, and directions for future research on and evaluation of CUREs. This report summarizes the outcomes and recommendations of this meeting.
Students can work with the same data at the same time and with the same tools as research scientists.iPlant Education, Outreach & Training Group (2008, personal communication)相似文献
29.
Neeldhara Misra 《Resonance》2008,13(7):662-679
In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. We may suggest strategies for dealing
with them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences
and viewpoints on matters related to teaching and learning science. 相似文献
30.