排序方式： 共有62条查询结果，搜索用时 15 毫秒
51.
Singh TD Barbhuiya MA Gupta S Shrivastav BR Jalaj V Agarwal N Tiwari PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):146-153
We have studied the expression of lactate dehydrogenase and its isoforms in gall bladder cancer, cholelithiasis and chronic
cholecystitis. Quantitative and qualitative assays of lactate dehydrogenase and its various isoforms were carried out in the
blood sera of patients and healthy controls along with parallel estimation of various liver function test enzymes. Statistical
analysis was done using the software Graph Pad Prism. Significantly high expression of lactate dehydrogenase along with alkaline
phosphatase and total bilirubin (P ≤ 0.05) was observed in all the three clinical conditions as compared to controls. LDH showed an increasing trend from stage
I to stage IV of GBC indicating a significant positive association with the disease progression. The levels of LDH 3 and 4
isoforms appeared significantly more elevated in GBC than cholelithiasis or chronic cholecystitis. We suggest that a careful
estimation of total LDH and its isoforms 3 and 4 alone or along with alkaline phosphatase and total bilirubin during different
clinical stages, like chronic cholecystitis, cholelithiasis and GBC, may prove to be a potentially useful biomarker in the
prognostic management of gall bladder diseases, specifically GBC. 相似文献
52.
Motoko Akiba Karen Sunday Cockrell Juanita Cleaver Simmons Seunghee Han Geetika Agarwal 《Equity & Excellence in Education》2013,46(4):446-462
State departments of education can play an important role in preparing teachers for effectively teaching diverse learners in our schools through state policies and standards on teacher certification and teacher education program accreditation. We conducted a content analysis of state standards on teacher certification and program accreditation in the 50 states and the District of Columbia to understand the type and characteristics of diversity-related requirements. We found that while all states addressed diversity in their standards, the type and characteristics of requirements varied across the states. The diversity requirements are ambiguous in most states, and only a small number of states utilize a “social reconstructionist” approach that focuses on preparing teachers to identify social inequality and take an active role to achieve educational and social equity. 相似文献
53.
Communicative Reconstruction of Resilience Labor: Identity/Identification in Disaster-Relief Workers
Drawing from the structurational theory of identification [Scott, Corman, & Cheney, 1998] and resilience theory [Buzzanell, 2010], our inquiry provides insight into the sustainability of disaster-relief worker involvement and the discursive processes whereby workers overcome emotional and physical challenges to create resilience labor. Analyzing 23 semi-structured interviews with disaster-relief workers of a non-profit organization, we define resilience labor as the dual-layered process of reintegrating transformative identities and identifications to sustain and construct ongoing organizational involvement and resilience. The identification frames align with familial, ideological, and destruction–renewal network ties that empower individuals to construct their identities in transformative ways. The frames can guide non-profit managers and volunteers working in extreme contexts characterized by societal conflicts or disruption to sustain themselves as they construct resilience labor. 相似文献
54.
A. Dasgupta J. K. Agarwal S. S. Dubey 《Indian journal of clinical biochemistry : IJCB》1992,7(1):33-36
The aim of the present study was to evaluate the serum levels of lecithin cholesterol acyl transferase and lipoprotein cholesterol in hyperthyroid patients. The serum levels of total cholesterol and triacylglycerols were also determined in order to assess the lipid status of these patients. It was observed that serum content of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density liproprotein cholesterol (HDL-C) were significantly lower (P<0.001) in these patients whereas serum triacylglycerols (Tg.) and very low density lipoprotein cholesterol (VLDL-C) (P>0.05) did not show any significant change as compared to control values. However, the serum level of lecithin cholesterol acyl transferase (LCAT) was significantly higher (P<0.001) in these patients. It is concluded that an increased LCAT activity plays a significant role in regulating lipoprotein cholesterol levels in hyperthyroid patients. 相似文献
55.
Garima Agarwal 《Resonance》2007,12(2):29-38
This article highlights an emerging field known as synthetic biology that envisions integrating designed circuits into living
organisms in order to instruct them to make logical decisions based on the prevailing intracellular and extracellular conditions
and produce a reliable behavior. The attempt is to design cells capable of sensing a bioweapon or an environmental pollutant,
activate its degradation pathway and perform bioremediation or carry out programmed cell death or synthesize complex biomaterials.
Within the living cell, a complex interplay of networks formed by genes and proteins mediate all cellular processes. The networks
in a system can be dissected into small regulatory gene circuit modules. Synthetic biology attempts to construct and assemble
such modules step by step, plug the modules together and modify them, in order to generate a desired behavior. The review
gives an insight into the creation of gene circuits and discusses the potential applications in the field of biotechnology,
medicine and environmental sciences.
Garima Agarwal is a research student in the Molecular Biophysics Unit, Indian Institute of Science. Her areas of research
interest include structural biology, bioinformatics and systems biology. 相似文献
56.
Leher Singh Charlene S. L. Fu Aishah A. Rahman Waseem B. Hameed Shamini Sanmugam Pratibha Agarwal Binyan Jiang Yap Seng Chong Michael J. Meaney Anne Rifkin‐Graboi the GUSTO Research Team 《Child development》2015,86(1):294-302
Comparisons of cognitive processing in monolinguals and bilinguals have revealed a bilingual advantage in inhibitory control. Recent studies have demonstrated advantages associated with exposure to two languages in infancy. However, the domain specificity and scope of the infant bilingual advantage in infancy remains unclear. In the present study, 114 monolingual and bilingual infants were compared in a very basic task of information processing—visual habituation—at 6 months of age. Bilingual infants demonstrated greater efficiency in stimulus encoding as well as in improved recognition memory for familiar stimuli as compared to monolinguals. Findings reveal a generalized cognitive advantage in bilingual infants that is broad in scope, early to emerge, and not specific to language. 相似文献
57.
Higher Education in India: Growth, Concerns and Change Agenda 总被引：3，自引：0，他引：3
Pawan Agarwal 《Higher Education Quarterly》2007,61(2):197-207
Higher education in India has grown large since the country's independence in 1947. Starting from a small base, the pace of growth was initially rapid. Initially, the pace of growth was rapid. Enrolments grew by 13 to 14 per cent per annum during the 1950s and 1960s. Over the past few decades, the growth rate has declined noticeably. Since then it has remained stable between 4 and 5 per cent. The nature of growth over the past two decades is, however, strikingly different from the growth in the previous period. This article maps the growth pattern of higher education in India with particular focus on enrolment growth and change in funding patterns. On analysis of the trends, it identifies the concerns and builds a case for change in Indian higher education so that the country's virtuous cycle of economic growth fuelled mainly by its large pool of qualified manpower is sustained. 相似文献
58.
Rachna Agarwal Sangeeta Sharma Neelam Chhillar Kiran Bala Neeraj Singh C. B. Tripathi 《Indian journal of clinical biochemistry : IJCB》2009,24(4):366-369
The present study was conducted to assess correlation of ammonia levels with valproate levels in epileptic patients presenting
with valproate toxicity and also whether liver enzymes and ammonia levels could serve as biochemical marker of valproate toxicity.
100 patients with epilepsy who had received valproate therapy for more than 12 months and had presented with valproate toxicity
and 100 controls were included in the study. The serum valproate, ammonia and liver enzymes were measured in these subjects.
In patients with valproate toxicity, the mean level of serum valproate was 110.91 ± 28.68 mg/dL (therapeutic range 50–100
mg/dL). Serum ammonia was higher (86.37 ± 39.90 μg/dL) in patients with valproate toxicity compared to controls (68.73 ± 30.07
μg/dL). Out of 100 patients, only 37 patients had serum valproate level > 120 mg/dL and 22 patients had raised levels of valproate
as well as ammonia. Age < 30 years and serum ammonia > 69 μg/dL is risk factors for valproate toxicity. Serum ammonia, liver
enzymes should be regularly investigated in patients on valproate therapy for early diagnosis of valproate toxicity. 相似文献
59.
Wen Xing Peng Shi Ramesh K. Agarwal Yuxin Zhao 《Journal of The Franklin Institute》2019,356(6):3590-3611
In practice, it is almost impossible to directly add a controller on each node in a complex dynamical network due to the high control cost and the difficulty of practical implementation, especially for large-scale networks. In order to address this issue, a pinning control strategy is introduced as a feasible alternative. The objective of this paper is first to recall some recent advancements in global pinning synchronization of complex networks with general communication topologies. A systematic review is presented thoroughly from the following aspects, including modeling, network topologies, control methodologies, theoretical analysis methods, and pinned node selection and localization schemes (pinning strategies). Fully distributed adaptive laws are proposed subsequently for the coupling strength as well as pinning control gains, and sufficient conditions are obtained to synchronize and pin a general complex network to a preassigned trajectory. Moreover, some open problems and future works in the field are also discussed. 相似文献
60.
Ashish Agarwal Anupama Hegde Charu Yadav Afzal Ahmad Poornima Ajay Manjrekar Rukmini Mysore Srikantiah 《Indian journal of clinical biochemistry : IJCB》2017,32(1):33-38
Impaired fasting glucose (IFG) is a high risk subclinical condition for the progression of type 2 diabetes mellitus and the hyperglycemia seen in this condition is because of the development of insulin resistance (IR). Obesity, inflammation, oxidative stress and many other factors have been implicated in development of IR in type 2 diabetes mellitus and its successive complications. Current study was aimed to ascertain the correlation of inflammation and oxidative stress markers [interleukin-6 (IL-6) and myeloperoxidase (MPO)] with IR in subjects with IFG. In this study, 80 subjects (40 IFG, 40 healthy controls) aged 25–45 years were selected based on their fasting plasma glucose (FPG) values and clinical history. Serum insulin, IL-6 and MPO were estimated by ELISA method and IR was calculated using Homeostatic Model Assessment Index 2 (HOMA 2) calculator. Pearson’s correlation coefficient and independent sample ‘t’ test were used for statistical analysis. IL-6 and MPO were found to be significantly elevated in IFG group and both correlates significantly with IR (r 0.413, r 0.645). Only MPO had significant correlation with FPG (r 0.388). In conclusion, the association of altered levels of IL-6 and MPO with IR are suggestive of a role of inflammation and oxidative stress in the initiation and progression of IR in individuals with IFG. 相似文献