Prevalence of +405G>C,−1154G>A Vascular Endothelial Growth Factor Polymorphism in Breast Cancer     

Rani James  G. Ramesh  Lakshmi Krishnamoorthy  Rahul Bhagat  Shilpa Chadaga  Vijayalaxmi Deshmane  Girija Ramaswamy 《Indian journal of clinical biochemistry : IJCB》2014,29(1):21-28

Vascular endothelial growth factor (VEGF) plays an important role in the development of Breast Cancer. The aim of this study was to investigate the association of polymorphisms in the VEGF gene on prognosis of Breast Cancer patients. This study comprised 200 patients with histologically confirmed cases of Breast cancer and 200 controls. Genotyping of the VEGF gene polymorphisms at +405G>C,−1154G>A, were performed by PCR-RFLP analysis. Preoperative plasma VEGF levels were determined by ELISA. Amongst both cases and controls, the genotypic distribution of the individual SNPs were all in Hardy–Weinberg equilibrium. Mean VEGF level was significantly elevated in cases compared to controls (t = 8.248; P < 0.001). No significant association was found between +405G>C,−1154G>A VEGF polymorphism and Breast Cancer. Logistic regression analysis revealed that 405GG & 1154GG were associated with higher levels of VEGF.  相似文献   

Exploring Kid Space in the wild: a preliminary study of multimodal and immersive collaborative play-based learning experiences     

Aslan  Sinem  Agrawal  Ankur  Alyuz  Nese  Chierichetti  Rebecca  Durham  Lenitra M.  Manuvinakurike  Ramesh  Okur  Eda  Sahay  Saurav  Sharma  Sangita  Sherry  John  Raffa  Giuseppe  Nachman  Lama 《Educational technology research and development : ETR & D》2022,70(1):205-230

Educational technology research and development - Parents recognize the potential benefits of technology for their young children but are wary of too much screen time and its potential deficits in...  相似文献   

Double codes: Community radio in Bolivia     

Ramesh Srinivasan  Juan Ramos-Martín 《The Information Society》2013,29(5):289-301

Abstract

In this article, we report results of interviews conducted with 20 informants at 8 community radio stations across the major regions of Bolivia. We explore the activism and community practices that have energized Bolivian community radio stations over a sustained period. We are in particular interested in the bottom-up networking by these community stations to interlink with each other. These networks actualize the goals of horizontal and participatory communication called for by Latin American theorists. We seek to learn from these endeavors and also contribute to their continued flourishing by analyzing potential threats to them.  相似文献   

Human capital and hierarchy     

M.J.Manohar Rao  Ramesh C. Datta 《Economics of Education Review》1985,4(1):67-76

This paper investigates the relationship between schooling, experience, hierarchy and earnings, using sample data drawn from one of the largest companies in the Indian private sector. A recursive path approach is posited and an analysis of the results indicates that hierarchic status acts as an intervening variable to channel the transmission effect of schooling and experience onto earnings. After controlling for differences in schooling, hierarchic status is shown to rise monotonically, albeit by diminishing increments, with experience, thereby offering support for the marginal productivity theory. In the process, the weak version of the screening hypothesis is also borne out.  相似文献   

Therapeutic uses ofCurcuma longa (turmeric)     

Pratibha Mehta Luthra  Rambir Singh  Ramesh Chandra 《Indian journal of clinical biochemistry : IJCB》2001,16(2):153-160

Curcuma longa commonly known as tumeric is traditionally used as a spice in Indian food. A wide range of biological activities e.g. anticancer, antimicrobial, antiinflammatory and free radical scavenging activity of the plant suggests a logical basis for its traditional use in foodstuff. Various phytothreapeutic uses ofCurcuma longa have been reviewed.  相似文献   

Serum calcium levels in patients with essential hypertension and their first degree relatives     

K. Sudhakar  M. Sujatha  S. Ramesh Babu  P. Padmavathi  P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2004,19(1):21-23

Calcium plays an important role in the pathophysiology of essential hypertension. Serum calcium levels were measured in 117 subjects with essential hypertension and 77 first-degree relatives. The results showed that serum calcium levels were significantly (p<0.01) decreased in both males and females with essential hypertension and their first-degree relatives when compared with the normotensive controls. This is the first study in Indian population.  相似文献   

Evaluation of FSH,LH and testosterone levels in different subgroups of infertile males     

S. Ramesh Babu  M. D. Sadhnani  M. Swarna  P. Padmavathi  P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2004,19(1):45-49

Gonadotropins (FSH, LH) and testosterone are the prime regulators of germ cell development. Abnormal spermatogenesis is often associated with altered serum gonadotropins and testosterone. FSH, LH and testosterone levels were estimated in 96 infertile men of whom 35 were azoospermic, 35 were oligozoospermic, 11 were with varicocele and 15 were with histopathological abnormalities like hypospermatogenesis, spermatid arrest and sertoli-cell only syndrome. Results showed statistically significant (p<0.05), increase in the mean FSH and LH levels in all the infertile males studied when compared with the fertile controls (n=35). However, there is no significant difference in the mean levels of testosterone between the infertile and fertile men.  相似文献   

Hypolipidemic Activity of Cassia tora Seeds in Hyperlipidemic Rats     

Vishnu Kumar Awasthi  Farzana Mahdi  Ramesh Chander  Ashok Kumar Khanna  Jitendra Kumar Saxena  Ranjana Singh  Abbas Ali Mahdi  Raj Kumar Singh 《Indian journal of clinical biochemistry : IJCB》2015,30(1):78-83

The hypolipidemic activity of Cassia tora (Chakvat, Chakunda) (Family: Caesalpiniaceae) seeds extract have been studied in two models of hyperlipidemia in rats. In an acute model, hyperlipidemia was induced by injecting a single dose of Triton WR-1339 (400 mg/kg, b.w.) intraperitonially in rats. Feeding with C. tora seed extract at the dose of 500 mg/kg, b.w. exerted significant lipid lowering effect as assessed by the reversal of plasma levels of total cholesterol, phospholipids, triglyceride and reactivation of post heparin lipolytic activity. In the chronic model, hyperlipidemia was induced by feeding with cholesterol rich-HFD in rats. The treatment with seeds extract of C. tora (500 mg/kg, b.w.) simultaneously for 15 days also caused lowering of lipid levels in plasma and liver following reactivation of plasma post heparin lipolytic activity and hepatic lipoprotein lipase activity in animals. The hypolipidemic activity of C. tora seeds was compared with a standard drug guggulipid (200 mg/kg, b.w.) in both models.  相似文献   

Cadmium, carcinogen, co-carcinogen and anti carcinogen     

Ramesh Chandra  Sujata K. Dass  Priyanka Tomar  Manisha Tiwari 《Indian journal of clinical biochemistry : IJCB》2001,16(2):145-152

As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. The atmosphere is a thin envelope which makes the worid a global village. Cd is the most toxic metal in air. As both the first and second messenger of the stress response, it is synergistically toxic with all other stressors, including many other carcinogens. Elimination of Pb and its replacement with added benzene in gasoline appears to have increased the toxicity of atmospheric Cd. With scientific understanding of the molecular basis of Cd's role in carcinogenesis and anti-carcinogenesis, primary cancer prevention can be practiced by reducing Cd and chemical air pollution and educating the public on smoke cessation, healthy eating habits and stress reduction. Using the existing information on Cd and its effects, determinations could be made on established cancers so that individualized treatment protocols can be developed to improve patient care.  相似文献   

Effects of some antituberculous and anti-leprotic drugs on cathepsins B,H and L     

Ramesh C. Kamboj  Neera Raghav  Ashwani Mittal  Shiwani Khurana  Rachna Sadana  Hari Singh 《Indian journal of clinical biochemistry : IJCB》2003,18(2):39-47

The cysteine proteinases like cathepsins B, L and H are main hydrolytic enzymes present in lysosomes and play an important role in intracellular protein degradation. Tuberculosis and leprosy, both are tissue- destructive diseases. Main drugs used in chemotherapy of these diseases may inhibit the main lysosomal cysteine proteinases i.e. cathepsins B, L and H released during tissue destruction and thus prevent the further destruction of tissue by these enzymes. So the aim of this study is to see the effect of antituberculous and antileprotic drugs on these proteolytic enzymes. The effect of commonly used antituberculous and antileprotic drugs was screened on the activities of purified brain lysosomal cysteine proteinases namely cathepsins B [EC 3.4.22.1], L [EC 3.4.22.15] and H [EC 3.4.22.16]. Among the antileprotic drugs, only clofazimine inhibited the enzymic activities whereas dapsone had no effect whatsoever. In antituberculous drugs, rifampicin was the most inhibitory while isoniazid had little inhibitory potency. Streptomycin and pyrazinamide did not effect the activities at all. As regards the mechanism of inhibition, clofazimine and isoniazid inhibited the enzymes in a non-competitive manner with K values of 0.25 mM and 5.0 mM for cathepsin B, 0.071 mM and 0.833 mM for cathepsin L and 1.513 mM and 0.885 mM for cathepsin H, While rifampicin could effect in a competitive manner with K_i values of 0.03 mM, 0.125 mM and 0.027 mM for cathepsin B, L and H respectively.  相似文献