Tumor necrosis factor alpha (TNF-α) and estrogen hormone in osteoarthritic female patients     

Pradeep Sharma  Neelima Singh  Vinod Singh  Sanjeev Singh  Harsh vardhan Singh  Sameer Gupta 《Indian journal of clinical biochemistry : IJCB》2006,21(1):205-207

Osteoarthritis of knee joints is a disease of old age in both sex. It is very common after the age of 40 years in elderly females or in postmenopausal phase of females. It is characterized by narrowing of space in joints due to inflammation. The exact mechanism of inflammation in this disease is not yet clear. Tumor necrosis factor alpha (TNF-α) may involve in onset of disease. The present study is being carried out in 130 female subject of age group 40–60 years suffering from osteoarthritis of knee joints and 50 normal healthy control female subjects. A correlation is made between TNF-α and estrogen and found significant inverse correlation (r<0.001), between TNF-α and estrogen hormone in osteoarthritic female patients as compared to normal healthy control female group.  相似文献   

Nanopore Technology: A Simple,Inexpensive, Futuristic Technology for DNA Sequencing     

P. D. Gupta 《Indian journal of clinical biochemistry : IJCB》2016,31(4):359-360

In health care, importance of DNA sequencing has been fully established. Sanger’s Capillary Electrophoresis DNA sequencing methodology is time consuming, cumbersome, hence become more expensive. Lately, because of its versatility DNA sequencing became house hold name, and therefore, there is an urgent need of simple, fast, inexpensive, DNA sequencing technology. In the beginning of this century efforts were made, and Nanopore DNA sequencing technology was developed; still it is infancy, nevertheless, it is the futuristic technology.  相似文献   

Applying Conceptual Blending to Model Coordinated Use of Multiple Ontological Metaphors     

Benjamin W. Dreyfus  Ayush Gupta  Edward F. Redish 《International Journal of Science Education》2015,37(5-6):812-838

Energy is an abstract science concept, so the ways that we think and talk about energy rely heavily on ontological metaphors: metaphors for what kind of thing energy is. Two commonly used ontological metaphors for energy are energy as a substance and energy as a vertical location. Our previous work has demonstrated that students and experts can productively use both the substance and location ontologies for energy. In this paper, we use Fauconnier and Turner's conceptual blending framework to demonstrate that experts and novices can successfully blend the substance and location ontologies into a coherent mental model in order to reason about energy. Our data come from classroom recordings of a physics professor teaching a physics course for the life sciences, and from an interview with an undergraduate student in that course. We analyze these data using predicate analysis and gesture analysis, looking at verbal utterances, gestures, and the interaction between them. This analysis yields evidence that the speakers are blending the substance and location ontologies into a single blended mental space.  相似文献   

Copper and Zinc Status in Psoriasis: Correlation with Severity     

Jyoti Aggarwal  Akansha Singh  Sanjeev Gupta  Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2021,36(1):120

Psoriasis is a common and an inflammatory skin disease. Trace elements play an important role in the skin metabolism such as keratinisation and melanin formation as well as immunological and inflammatory reactions. Henceforth, the present study was aimed to evaluate the essential metals with special reference to Cu and Zn. In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease.  相似文献   

Effect of Resveratrol and Nicotine on PON1 Gene Expression: In Vitro Study     

Nidhi Gupta  Ramesh Kandimalla  Kumari Priyanka  Gagandip Singh  Kiran Dip Gill  Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2014,29(1):69-73

Dietary and lifestyle factors have been shown to have a profound effect on paraoxonase-1 (PON1) activity. Cigarette smoke has been shown to inhibit its mass and activity where as resveratrol has been shown to enhance it. We exposed hepatoma derived cell line (HepG2) to resveratrol and nicotine in varying doses and measured PON1 enzymatic activity and PON1 gene expression. In addition, total protein content of HepG2 cells was also measured. Resveratrol in a dose of 15 μmol/l or above significantly increased the PON1 enzyme activity (p > 0.001) where as nicotine in a dose of 1 μmol/l or higher significantly reduced it (p < 0.05). The resveratrol in this dose also enhanced the PON1 gene expression whereas nicotine decreased it as compared to controls. However, the protein conent of cells was not changed suggesting that they were not cytotoxic in the doses used. Till date the antioxidant vitamins have shown disappointing results against LDL oxidation and cardiovascular protection. However, the effect of resveratrol on PON1 gene expression and activity was significant, suggesting increase in PON1 activity and enhanced gene expression may be its alternative mechanism for offering protection against cardiovascular disease and may be an potential pharmacological agent which can be used for this.  相似文献   

An Informal Science Education Program’s Impact on STEM Major and STEM Career Outcomes     

Habig  Bobby  Gupta  Preeti  Levine  Brian  Adams  Jennifer 《Research in Science Education》2020,50(3):1051-1074

Research in Science Education - While there is extensive evidence that STEM careers can be important pathways for augmenting social mobility and for increasing individual prestige, many youth...  相似文献   

Maternal mind-mindedness and attachment security as predictors of theory of mind understanding   总被引：1，自引：0，他引：1  

Meins E  Fernyhough C  Wainwright R  Das Gupta M  Fradley E  Tuckey M 《Child development》2002,73(6):1715-1726

This study investigated relations between social interaction during infancy and children's subsequent theory of mind (ToM). Infant-mother pairs (N = 57) were observed in a free-play context at 6 months. Interactions were coded for (a) mothers' use of mental state language that commented appropriately on the infants' mental states, and (b) mothers' use of mental state language that did not appropriately reflect their infants' minds. A third variable was (c) security of attachment, which was assessed using the Strange Situation procedure at 12 months. Performance on a battery of ToM tasks at 45 and 48 months was positively correlated with (a), but was not related to (b) or (c). A regression analysis showed that mothers' use of appropriate mental state comments independently predicted overall ToM performance, accounting for 11% of the variance. Children's verbal ability was the only other independent predictor of ToM performance, accounting for 16% of the variance. These findings represent the earliest known social predictor of individual differences in ToM.  相似文献   

‘The fruit caught between two stones’: the conflicted position of teachers within Aceh's independence struggle†     

Mieke T.A. Lopes Cardozo  Ritesh Shah 《Globalisation, Societies & Education》2016,14(3):331-344

ABSTRACT

This paper explores the challenging situation faced by teachers as professionals and members of the community in Aceh, Indonesia during the province's civil war. It reveals how teachers’ sense of agency during this period was deeply influenced by the economic/material, political and socio-cultural condition at that time – conditions and experiences which today have bearing on a place for teachers in the post-conflict peace-building process occurring in the province. During the conflict, teachers struggled to balance their strategic societal positioning – as civil servants and community members – and found themselves caught in the middle of a complex range of hegemonic and counter-hegemonic forces at play. This position of constraint, we argue, limited the ability of teachers to act as peace-builders during the conflict, and continues to influence teachers’ ability to function in such ways today.  相似文献   

Ethnic Identity Development and Acculturation Preferences Among Minority and Majority Youth: Norms and Contact          下载免费PDF全文

Roberto González  Brian Lickel  Manisha Gupta  Linda R. Tropp  Bernadette P. Luengo Kanacri  Eduardo Mora  Pablo De Tezanos‐Pinto  Christian Berger  Daniel Valdenegro  Oscar Cayul  Daniel Miranda  Patricio Saavedra  Michelle Bernardino 《Child development》2017,88(3):743-760

This article tests a longitudinal model of the antecedents and consequences of changes in identification with indigenous (Mapuche) among indigenous and nonindigenous youth in Chilean school contexts over a 6‐month period (633 nonindigenous and 270 Mapuche students, M_ages = 12.47 and 12.80 years, respectively). Results revealed that in‐group norms supporting contact and quality of intergroup contact at Time 1 predicted student's changes in Mapuche identification at Time 2, which in turn predicted changes in support for adoption of Chilean culture and maintenance of Mapuche culture at Time 2; some of the relationships between these variables were found to be moderated by age and ethnicity. Conceptual and policy implications are addressed in the Discussion .  相似文献   

Effect of radiotherapy on serum sialic acid level in carcinoma cervix     

H. R. Mali  M. L. B. Bhatt  M. P. Singh  S. M. Natu  J. P. Gupta 《Indian journal of clinical biochemistry : IJCB》1996,11(1):56-58

Serum sialic acid levels were determined in 66 patients of carcinoma cervix and 25 control women matched for age. Mean sialic acid level was significantly elevated (p<0.001) in cancer cervix patients as compared to controls. Patients were treated with 50–65 Gy of radiation in 5–6.5 weeks. Post-therapy levels were again determined. Radiotherapy caused decline in serum sialic acid level in all the patients except one. Mean post-therapy level was significantly lower as compared to pretreatment level (p<0.001). It was also observed that fall in sialic acid level was significantly higher (p<0.05) in early stage patients as compared to late stage. No relationship was observed in the dose of radiation and fall in serum sialic acid level. A significantly higher fall in serum sialic acid level was observed in patients having complete clinical response as compared to partial or nonresponders to radiation treatment (p<0.001).  相似文献