排序方式： 共有36条查询结果，搜索用时 15 毫秒
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Neda Dadgar Maedeh Koohi Moftakhari Esfahani Sepideh Torabi Seyed Ebrahim Alavi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2014,29(4):501-504
This study is aimed to investigate the nanoliposomal artemisinin preparation, and its implementation on breast cancer cells. Side effects have been one of the common challenges of drug usage, as well as cancer treatment. In order to reduce such effects, nanotechnology has been a great help. Nanoliposomes are provided through reverse phase evaporation. In this method, certain proportions of phosphatidylcholine, cholesterol and artemisinin were mixed together. Besides, the obtained formulation was pegylated by using polyethylene glycol 2000 in order to increase its stability and solubility. The mean diameter of non-pegylated and pegylated liposomal artemisinin was determined by Zeta sizer system. The percent of drug released from liposome was performed by dialysis. The encapsulation efficiency of both formulations was estimated by spectrophotometry method. As a result, encapsulation and drug release of nanoliposomal formulation were more than the pegylation of the same formulation. In addition, this study indicated that cytotoxicity effect of pegylated nanoliposomal artemisinin was more, in comparison with nanoliposomal artemisinin. 相似文献
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Seyed Ebrahim Alavi Maedeh Koohi Moftakhari Esfahani Fatemeh Alavi Fatemeh Movahedi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2013,28(3):299-302
It is clear that cancer is one of the most mortal diseases in the world and the most prevalent among women is breast cancer. As hydroxyurea (HU)—a drug which is used in chemotherapy—has many adverse effects in long-term despite of its therapeutic properties, we made use of nano drug delivery technology in order to reduce adverse effects and increase therapeutic index. Thus, liposomation is a novel way in drug delivery systems. In this study a mixture of phosphatidylcholine and cholesterol was mixed and HU was added to the resultant mixture. The mean diameter of the nanoliposomal HU measured with the Zeta Sizer device (equal to 402.5 nm) and its encapsulation efficiency was 70.8 %. Besides, using dialysis, the pattern of drug release from nanoliposomes has been studied and the results showed that the drug release of nanoliposomal drug within 28 h was equal to 25.85 %. This study showed that the cytotoxicity effect of nanoliposomal drug is more than that of the standard drug. 相似文献
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Despite the significant role of oral presentation in the academic context, many university students evade opportunities for participation due to low self-efficacy. The present study has been conducted to compare oral presentation self-efficacy of English as a Foreign Language (EFL) learners with undergraduates and postgraduates of Non-EFL majors, and to investigate the relationship of this construct with their teaching and prior academic oral presentation experiences as two modes of Bandura’s [(1995). Exercise of personal and collective efficacy in changing societies. In A. Bandura (Ed.), Self-efficacy in changing societies (pp. 1–45). New York: Cambridge University Press] mastery experience. Extracting the oral presentation sub-skills from the literature, an oral presentation self-efficacy questionnaire with 38 five-Likert scale items was constructed. A two-way between-group ANOVA was run on the responses of a total 48 postgraduates (25 EFL and 23 Non-EFL) and 63 undergraduates (28 EFL and 35 Non-EFL) selected randomly from two of the universities in Iran. The results indicated no difference between EFL and Non-EFL students, whether at undergraduate or postgraduate level, in terms of their oral presentation self-efficacy. Spearman’s correlation coefficient, however, showed a strong positive correlation between the two modes of mastery experience and oral presentation self-efficacy (r?=?.44, n?=?111, P?r?=?.42, n?=?111, P?相似文献
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Reza Gharibi Amir Hossein Rasekh Mohammad Hadi Sadreddini Seyed Mostafa Fakhrahmad 《Information processing & management》2018,54(6):1058-1076
Bug reports are an essential part of a software project's life cycle since resolving them improves the project's quality. When a new bug report is received, developers usually need to reproduce the bug and perform code review to locate the bug and assign it to be fixed. However, the huge number of bug reports and the increasing size of software projects make this process tedious and time-consuming. To solve this issue, bug localization techniques try to rank all the source files of a project with respect to how likely they are to contain a bug. This process reduces the search space of source files and helps developers to find relevant source files quicker. In this paper, we propose a multi-component bug localization approach that leverages different textual properties of bug reports and source files as well as the relations between previously fixed bug reports and a newly received one. Our approach uses information retrieval, textual matching, stack trace analysis, and multi-label classification to improve the performance of bug localization. We evaluate the performance of the proposed approach on three open source software projects (i.e., AspectJ, SWT, and ZXing) and the results show that it can rank appropriate source files for more than 52% of bugs by recommending only one source file and 78% by recommending ten files. It also improves the MRR and MAP values compared to several existing state-of-the-art bug localization approaches. 相似文献
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Mazeyar Parvinzadeh Gashti Julien Bellavance Otini Kroukamp Gideon Wolfaardt Seyed Mohammad Taghavi Jesse Greener 《Biomicrofluidics》2015,9(4)
Time-lapse videos of growing biofilms were analyzed using a background subtraction method, which removed camouflaging effects from the heterogeneous field of view to reveal evidence of streamer formation from optically dense biofilm segments. In addition, quantitative measurements of biofilm velocity and optical density, combined with mathematical modeling, demonstrated that streamer formation occurred from mature, high-viscosity biofilms. We propose a streamer formation mechanism by sudden partial detachment, as opposed to continuous elongation as observed in other microfluidic studies. Additionally, streamer formation occurred in straight microchannels, as opposed to serpentine or pseudo-porous channels, as previously reported. 相似文献
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Sohrab Enayati Seyed Ali Asghar Akbari Mousavi Seyed Mohammad Ebrahimi Majid Belbasi Mostafa Sultan Bayazidi 《Journal of The Franklin Institute》2011,348(10):2813-2822
In this study, the hot backward extrusion of Ti–6Al–4V alloy is considered by finite element analysis and experiments. The effects of reduction and initial billet temperature on the force required for extrusion, on the maximum strain produced and on the formation of surface cracks are discussed. The simulation results show that the increase of temperature at high reduction is considerable and that can be reached 150 °C in the billet and punch interface. Moreover, the maximum strain is predicted at the interface of billet and punch. The study shows that the temperature rise and plastic deformation may induce surface cracks. 相似文献
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Seyed Ebrahim Alavi Maedeh Koohi Moftakhari Esfahani Soheil Ghassemi Azim Akbarzadeh Gholamhossein Hassanshahi 《Indian journal of clinical biochemistry : IJCB》2014,29(1):84-88
Breast cancer is one of the most frequent cancer types within women population. Hydroxyurea (HU) is a chemotherapy compound for treatment of patients with cancer diagnosis, including breast cancer associated with several adverse effects. In this study, we applied nanotechnology to decreased drug side effects along with improvement of therapeutic index. Liposomation is widely used in modern pharmacological developments in order to enhance the effects of the drugs. To achieve this, in this study a mixture of phosphatidylcholine and cholesterol was made up and HU was added to the resultant mixture, was then pegylated using Polyethylene Glycol 2000 to increase resistance, applicability and solubility. The mean diameters of nanoliposomal and pegylated nanoliposomal HU were measured by Zeta sizer device and obtained about 402.5 and 338.2 nm. The efficiency of non-pegylated and pegylated liposomal HU was 70.8 and 64.2, respectively. Releasing HU in both formulations was estimated about 25.8 and 21.7 %. Also, this study investigated the cytotoxicity effect of nanoliposomal and pegylated nanoliposomal HU using MTT assay. Results of this investigation showed that the cytotoxic properties of pegylated HU was 3.6 % more than those non-pegylated form, while was 38.93 % more than ordinary from of HU. This study showed that the stability, releasing pattern and cytotoxicity of the pegylated nanoliposomal HU is better than that of nanoliposomal HU. 相似文献
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