From ‘Particulate factors’ to ‘Designer genes’: A hundred years of genetics     

Amitabh Joshi 《Resonance》2000,5(9):3-5

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International trends in health science librarianship part 12: South Asia (India,Pakistan and Sri Lanka)     

Medha Joshi  Mumtaz Ali Anwar  Midrar Ullah  Chandrani Kuruppu 《Health information and libraries journal》2014,31(4):318-324

This is the 12th in a series of articles exploring international trends in health science librarianship. This issue describes developments in health science librarianship in the first decade of the 21st century in South Asia. The three contributors report on challenges facing health science librarians in India, Pakistan and Sri Lanka. There is consensus as to the need for education, training and professional development. Starting in the next issue, the focus will turn to Africa, starting with countries in southern Africa. JM  相似文献   

The role of health information kiosks in diverse settings: a systematic review     

Ashish Joshi  Kate Trout 《Health information and libraries journal》2014,31(4):254-273

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Sir R A Fisher and the evolution of genetics     

Amitabh Joshi 《Resonance》1997,2(9):27-31

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Quantitative analysis of a panel of gene expression in prostate cancer——with emphasis on NPY expression analysis     

LIU Ai-jun  FURUSATO Bungo  RAVINDRANATH Lakshmi  CHEN Yong-mei  SRIKANTAN Vasanta  MCLEOD David G.  PETROVICS Gyorgy  SRIVASTAVA Shiv 《Journal of Zhejiang University. Science. B》2007,8(12)

Objective: To investigate molecular alterations associating with prostate carcinoma progression and potentially provide information toward more accurate prognosis/diagnosis. Methods: A set of laser captured microdissected (LCM) specimens from 300 prostate cancer (PCa) patients undergoing radical prostatectomy (RP) were defined. Ten patients representing "aggressive" PCa, and 10 representing "non-aggressive" PCa were selected based on prostate-specific antigen (PSA) recurrence,Gleason score, pathological stage and tumor cell differentiation, with matched patient age and race between the two groups.Normal and neoplastic prostate epithelial cells were collected with LCM from frozen tissue slides obtained from the RP specimens.The expressions of a panel of genes, including NPY, PTEN, AR,AMACR, DD3, and GSTP1, were measured by quantitative real-time RT-PCR (TaqMan), and correlation was analyzed with clinicopathological features. Results: The expressions of AMACR and DD3 were consistently up-regulated in cancer cells compared to benign prostate epithelial cells in all PCa patients, whereas GSTP1 expression was down regulated in each patient. NPY, PTEN and AR exhibited a striking difference in their expression patterns between aggressive and non-aggressive PCas (P=0.0203, 0.0284, and 0.0378, respectively, Wilcoxon rank sum test). The lower expression of NPY showed association with "aggressive" PCas based on a larger PCa patient cohort analysis (P=0.0037,univariate generalized linear model (GLM) analysis). Conclusion: Despite widely noted heterogeneous nature of PCa, gene expression alterations of AMACR, DD3, and GSTP1 in LCM-derived PCa epithelial cells suggest for common underlying mechanisms in the initiation of PCa. Lower NPY expression level is significantly associated with more aggressive clinical behavior of PCa; PTEN and AR may have potential in defining PCa with aggressive clinical behavior. Studies along these lines have potential to define PCa-associated gene expression alterations and likely co-regulation of genes/pathways critical in the biology of PCa onset/progression.  相似文献   

Visual Instruction to Enhance Teaching of Technical Subject to Design Students     

Siu‐Kit Lau  Noopur Joshi  Ming Fai Pang 《The International Journal of Art & Design Education》2021,40(1):165-183

Visual instruction complementing verbal lectures is known to promote learning among students. In this study, the role of visual instruction in engaging learners effectively via the simplification of technical concepts was examined. Different aspects of visualisation, such as order of presenting and dimensionality, were tested to observe their effect on students’ approach to learning and learning outcomes. In this mixed‐method quasi‐non‐experimental explanatory study, visual instruction was applied in one of the undergraduate architecture modules that teaches fundamentals of building systems, which students often find difficult to comprehend. Three key variables, including spatial cognitive ability, approach to learning and learning outcomes, were measured using statistically valid instruments along with students’ feedback and interviews. These factors were also measured for the control group that did not receive visual instruction (n = 32), to assess the effect of the intervention. When taught with visualisation, students (n = 69), showed a significant increase in deep approach to learning (e.g., deep motive: t = 2.584, p = 0.011). In interviews, students expressed a deeper interest in the subject and reported that the topic was engaging in class. Visualisation favours students with a higher spatial ability and, thus, is useful for design students who receive spatial ability training in the course. Two‐dimensional visuals must be followed and preceded by three‐dimensional visuals to provide advanced organisation and the connection of new knowledge with known organisational models to be made.  相似文献   

Lipid abnormalities in chronic renal failure     

Rajesh Bhagwat  S. P. Joshi  Pradeep Salgia  Achal Sepaha 《Indian journal of clinical biochemistry : IJCB》1997,12(1):81-85

Lipid abnormalities remain to be a major cause of early mortality in patients with chronic renal failure (CRF). In present study, 114 (one hundred fourteen) CRF patients without any additional cause of dyslipidemia were divided into groups on the basis of etiologies of CRF. Blood samples from each group were analyzed for total cholesterol, triglyceride and HDL cholesterol along with blood urea nitrogen and serum creatinine. 25 healthy individuals without any obvious disease were taken as control. Patients from all the groups showed a marked hypertriglyceridemia of 232 (SD±77) mg/dl (P<0.001) as compared to control. Levels of HDL cholesterol were found to be significantly low 20 (±11) mg/dl (p<0.001) in all the groups. LDL cholesterol showed an increase 104 (±30) mg/dl as compared to control group which is not statistically significant. Present study reveals that, CRF patients show an uniform dyslipidemia irrespective of etiologies leading to CRF. This dyslipidemia is also independent of serum creatinine levels. Although, these lipid abnormalities may not solely cause mortality in CRF patients, they may act as modulators in accelerating atherogenesis which in turn cause early mortality in CRF patients.  相似文献   

Kaleidoscoping public understanding of science on hygiene, health and plague: a survey in the aftermath of a plague epidemic in India     

Raza G  Dutt B  Singh S 《Public understanding of science (Bristol, England)》1997,6(3):247-267

In September 1994 a plague epidemic hit a number of cities in India. Though the spread of the disease was controlled within a short period of about one month, its influences on various channels of information, on the functioning of government departments (especially health and sanitation), on the scientific community and on people's scientific information level were remarkable. This paper analyzes the responses of 1127 individuals interviewed in December 1994. The data indicates high levels of informedness about health, hygiene and plague, with little reference to extra-scientific explanations of the causes of the epidemic. Respondents expressed a high degree of confidence in the modern system of medicine. From this analysis we also infer that the public could not be described as 'superstitious', 'unscientific' or 'unhygienic': only when denied access to information and civic amenities did they show extra-scientific thinking or 'unhygienic' behaviour.  相似文献   

Fostering inclusive growth through e-Governance Embedded Rural Telecenters (EGERT) in India     

Gopal Naik  Siddharth Joshi  K.P. Basavaraj 《Government Information Quarterly》2012

In the recent years, two significant changes have taken place in an effort to address rural poor: Businesses have started recognizing potential of rural markets and governments have started using telecenters for providing G2C services to rural citizens. In India, the national and sub-national governments have supported businesses to establish telecenters in rural areas to provide information technology enabled services. However, the focus so far has been mostly on B2C services and viability of telecenters is being questioned. We argue that sustainability of these centers can be enhanced considerably if government services are embedded. Also, designing these telecenters with embedded G2C services would significantly improve effectiveness of their delivery and strengthen government information network, to foster inclusive growth.  相似文献   

Ability-grouping and problem behavior trajectories in childhood and adolescence: Results from a U.K. population-based sample     

Efstathios Papachristou  Eirini Flouri  Heather Joshi  Emily Midouhas  Glyn Lewis 《Child development》2022,93(2):341-358

Ability-grouping has been studied extensively in relation to children's academic, but not emotional and behavioral outcomes. The sample comprised 7259 U.K. children (50% male) with data on between-class and within-class ability-grouping at age 7. Peer, emotional, hyperactivity, and conduct problems were measured at ages 7, 11, and 14 years. Children in low within-class ability groups showed more hyperactivity and emotional problems across the study period compared to non-grouped children, after adjustments for the different types of ability grouping and confounding. Additionally, children in the middle within-class ability groups showed more, and those in the top within-class groups less, hyperactivity compared to non-grouped children, after adjustment. Children in lower within-class groups should be monitored closely to ensure that their well-being is not compromised.  相似文献