The Diploma in Information Technology with Distance Teaching Methods     

Francesco Lata  Enrichetta Librandi 《European Journal of Engineering Education》1995,20(2):211-218

The Consortium for Distance University was founded in 1984 to set up a distance teaching university system in Italy. Its activity started in 1986 with the foundation of the Special Purpose School of Information Technology based on distance teaching methods. In 1991 a university diploma was established according to the European educational system. The 3‐year programme includes 28 learning modules and a final apprenticeship. The modules have been developed through a number of learning units, in the form of printed materials and computer‐aided instruction packages that enable learners to organize their own learning autonomously. Assistance to learners takes place in study centres where students meet tutors and use the hardware equipment needed for the software materials. In the academic year 1994/95, an experimental delivery of the university diploma in information technology through the CMC technologies will begin at some Italian universities so that it will be possible to demonstrate how the new modern technologies help students to manage their learning process in real time.  相似文献   

Role of Oncofetal Protein CR-1 as a Potential Tumor Marker for Oral Squamous Cell Carcinoma     

Anu Jain  Sumanth Kumar Mallupattu  Reetu Thakur  Satyawati Mohindra  Amanjit Bal  Ashim Das  Sushmita Ghoshal  Arnab Pal 《Indian journal of clinical biochemistry : IJCB》2021,36(3):288

Cripto-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancer, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study, we have evaluated the role of soluble CR-1, in serum as a potential tumor marker for OSCC. CR-1 was estimated using sandwich ELISA in serum samples of 50 biopsy proven OSCC patients (pre and post treatment) along with age and gender matched healthy controls. Immunohistochemistry was also done in corresponding tumor tissue sections to check the expression of CR-1. Pre-treatment CR-1 was found to be 2.25-fold higher in serum of OSCC patients as compared to control (p < 0.0001***), which was reduced to 1.6 folds post treatment (p = 0.0006***). CR-1 levels were comparatively higher in early stage of disease. Upon IHC 80% of the cases were found to be positive for CR-1. This study provides evidence that serum levels of CR-1 are elevated in patients of Oral Squamous Cell Carcinoma, which decrease post treatment. Also, the association of expression of protein with tumor progression predicts CR-1 as a molecule that can be further evaluated as a potential tumor maker in OSCC.  相似文献   

Impairment of Mitochondrial–Nuclear Cross Talk in Neutrophils of Patients with Type 2 Diabetes Mellitus     

Saba Khan  Gorantla V. Raghuram  Neelam Pathak  Subodh K. Jain  Dolly H. Chandra  Pradyumna K. Mishra 《Indian journal of clinical biochemistry : IJCB》2014,29(1):38-44

Increased leukocyte apoptosis is intrinsically linked to disease patho-physiology, susceptibility to and severity of infections in type 2 diabetes mellitus (T2DM) patients. A consistent defect in neutrophil function is considered central to this increased risk for infections. Although redox imbalance is considered a potential mediator of these associated complications, detailed molecular evidence in clinical samples remains largely undetected. The study consisted of three groups (n = 50 each) of Asian Indians: early diagnosed diabetic patients, cases with late-onset diabetic complications and age and gender-matched healthy controls. We evaluated mitochondrial oxidative stress, levels of nuclear DNA damage and apoptosis in peripheral blood neutrophils isolated from T2DM patients. We observed that in both early and late diabetic subjects, the HbA1c levels in neutrophils were altered considerably with respect to healthy controls. Increased oxidative stress observed in both early and late diabetics imply the disentanglement of fine equilibrium of mitochondria-nuclear cross talk which eventually effected the augmentation of downstream nuclear γH2AX activation and caspase-3 expression. It would be overly naïve to refute the fact that mitochondrial deregulation in neutrophils perturbs immunological balance in type 2 diabetic conditions. By virtue of our data, we posit that maneuvering mitochondrial function might offer a prospective and viable method to modulate neutrophil function in T2DM. Nevertheless, similar investigations from other ethnic groups in conjunction with experimental evidences would be a preeminent need. Obviously, our study might aid to comprehend this complex interplay between mitochondrial dysfunction and neutrophil homeostasis in T2DM.  相似文献   

Hypoxic Stress Induced TREM-1 and Inflammatory Chemokines in Human Peripheral Blood Mononuclear Cells     

K. P. Mishra  Sonal Jain  Lilly Ganju  S. B. Singh 《Indian journal of clinical biochemistry : IJCB》2014,29(2):133-138

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Digital libraries initiatives in India     

P.K. Jain  Parveen Babbar 《International Information and Library Review》2013,45(3):161-169

Abstract

Digital libraries (DLs) have evolved, and developments in information technology have changed the concept of the library from one of print and paper media to digital media. The success of a DL depends upon the computers, communication skills, and knowledge of library professionals in connection with modern technology. In the present scenario, we stand at a transition from the traditional library to a global DL. The technology-based idea is to provide universal access to digital content available only in a DL environment.

Today the emergence of digital technology and computer networks has provided a means whereby information can be stored, retrieved, disseminated and duplicated in a fast and efficient manner. On a global level, DLs have made considerable advances both in technology and its application. India still has far to go if the nation is to benefit from this movement. Only sporadic and partial attempts have been made towards DL initiatives in India.

The basic objective of DL initiatives in India has been to preserve the art, culture and heritage of this country. All projects aimed at creating DLs concentrate only on specialized collections. The DL initiative in India is still at a nascent or embryonic stage. But with the initiative like DL policy, it can also be said that the nation is serious about DL implementation.  相似文献   

Study on Relation of Metabolic Syndrome with Menopause   总被引：1，自引：0，他引：1  

Sapna Goyal  Mriganka Baruah  Runi Devi  Kalpana Jain 《Indian journal of clinical biochemistry : IJCB》2013,28(1):55-60

This study is carried out to determine the prevalence of metabolic syndrome (MS) in 148 women between 36 to 65 years using the International Diabetes Federation criteria in the North-Eastern part of India. The prevalence of MS and all its individual components were found to be significantly higher among postmenopausal as compared to premenopausal and perimenopausal women. Various components of MS except waist circumference shows a significant increase and homeostasis model assessment index for insulin resistance also showed significant differences between the three groups. All the MS diagnostic markers (except serum high density lipoprotein) showed a strong positive correlation with MS score among the groups. Further MS score correlated with indicators of insulin resistance evaluated. This study concluded that MS is highly prevalent among North-East Indian postmenopausal women seeking primary health care and its determinant factors related to age and sedentary habits. Thus recognizing and treating MS early with proper intervention can minimize complication.  相似文献   

Mathematics anxiety as a function of multidimensional self-regulation and self-efficacy     

Sachin Jain  Martin Dowson 《Contemporary educational psychology》2009

This study tested the veracity of a model of Mathematics Anxiety as the end-point of related self-regulatory and self-efficacy processes. Data were collected in India from 232, eighth grade students on the Motivated Strategies for Learning Questionnaire and the Mathematics Anxiety Scale. Demographic information such as student’s gender, age, marks scored in last mathematics exam and occupation of both parents was also collected. The measures in the study were tested to ascertain their psychometric properties, including any effect that gender had on these properties. A Structural Equation Model of Mathematics Anxiety was then constructed and evaluated based in the measures tested in the related measurement models.  相似文献   

Role of heat stable fraction of alkaline phosphatase as an adjunct to ca 125 in monitoring patients of epithelial ovarian carcinoma     

P. K. Nigam  A. Jain  P. Goyal  R. Chitra 《Indian journal of clinical biochemistry : IJCB》2005,20(2):43-47

Heat stable fraction (HSF) of alkaline phosphatase (ALP) was evaluated as an adjunct to CA 125 as a tumour marker for epithelial ovarian cancer in a follow-up study. In our study group 63.4% of patients had elevated HSF levels (≥10U/L) and 93.3% had elevated CA 125 levels (>35U/mL). The sensitivity of CA 125 and HSF was 93.3% and 63.3% respectively. The decline in the activity of HSF, over the pre-op levels was highly significant after the first (p=0.001) chemotherapy cycle and significant after the second and third cycles (p<0.029). Thereafter, HSF activity was almost undetectable. The decrease in CA 125 levels over the pre-op levels was significant after the first, second, third (p<0.001) and fourth (p<0.034) chemotherapy cycle. HSF can be used alone or as an adjunct to CA 125 in screening and monitoring patients of ovarian carcinoma especially in remote areas where sophisticated facilities are not available and in patients in which CA 125 levels are not raised preoperatively.  相似文献   

Study of Association of Leptin and Insulin Resistance Markers in Patients of PCOS     

Huma Nasrat  Surajeet K. Patra  Binita Goswami  Anju Jain  Chitra Raghunandan 《Indian journal of clinical biochemistry : IJCB》2016,31(1):104-107

Polycystic ovary syndrome (PCOS) is a common endocrinological disorder among women of the reproductive age group with long term sequelae which include diabetes mellitus, hypertension and CAD. The present study was conducted to evaluate the association of leptin—an adipokine playing an important role in carbohydrate metabolism and markers of insulin resistance among women with PCOS. Sixty diagnosed cases of PCOS as per Rotterdam criteria were enrolled in this study after informed written consent. Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR). HOMA-IR was calculated as the product of the fasting plasma insulin value (mU/ml) and the fasting plasma glucose value (mg/dl), divided by 405 and HOMA β was calculated as 360 × [insulin]/([glucose] − 63) % (glucose in mg/dl). Estimation of serum leptin levels was done by ELISA using leptin ELISA kit from (DRG). A positive correlation of serum leptin levels was observed with markers of insulin resistance. Multiple regression analysis with HOMA-IR as dependent variable demonstrated a statistically significant contribution of fasting insulin levels. This study highlights the role of leptin in alterations in carbohydrate metabolism in patients with PCOS.  相似文献   

Biochemical changes during exchange transfusion in hyperbilirubinemia in term newborn babies     

Amit Jain  D. Puri  M. M. A. Faridi 《Indian journal of clinical biochemistry : IJCB》1997,12(2):119-124

Double volume (170 ml/kg body weight) exchange transfusion was done in 52 term infants in the first week of life for neonatal hyperbilirubinemia. The M:F ratio was 1.08:1 and 37 (71.1%) babies were of low birth weight. Causes of jaundice were hemolytic in 46.2% and non-hemolytic in 41.3% cases; in 13.5% babies no cause of jaundice could be found. After exchange transfusion a fall of 14.6% and 47.4% was observed in the hemoglobin and serum bilirubin levels respectively. There was significant (p=0.0414) rise in the mean mid exchange and post-exchange serum sodium levels as compared to pre-exchange values and it was found to be due to higher donor's serum sodium levels (p=0.007). There was no effect on the serum potassium levels during or after ET. In general serum calcium levels significantly increased at mid-exchange period (p=0.0029) but post-exchange levels were same as pre-exchange. Donor's serum calcium level had no effect on the infant's serum calcium level (p=0.993). There was no change in the serum phosphate and blood urea levels during and after exchange-transfusion. The plasma glucose was significantly raised during and after ET and plasma glucose of the donors had significant effect on the infant's plasma glucose levels (p=0.043). Similarly plasma osmolality also showed significant increase during and after ET which was due to the effect of donor's plasma osmolality (p=0.007).  相似文献