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21.
Mala Mahto Mukunda Kumar Sushil Kumar Ayan Banerjee 《Indian journal of clinical biochemistry : IJCB》2021,36(2):235
Hyperkalemia is a life threatening electrolyte derangement that must be recognized and treated quickly. Pseudohyperkalemia is defined as a difference between serum and plasma potassium concentration of more than 0.4 meq/L with serum values on the higher side when both the samples are obtained at the same time, remain at room temperature and are tested within 1 h of sample collection. Given the implication of basing medical decisions on falsely elevated potassium levels, timely identification of the entity of pseudohyperkalemia and differentiating it from true hyperkalemia becomes utmost important. Here we present a case report of a 36 year old female admitted with a provisional diagnosis of pyrexia of unknown origin with hepatosplenomegaly and anaemia under evaluation. During hospital stay her potassium levels in whole blood, serum and plasma reportedly differed significantly. An abnormal WBC count beyond assay range was reported and during subsequent investigations this lead to a peripheral smear being advised and diagnosis revealed chronic lymphoblastic leukaemia with blast crisis and 86% blast cells. In patients with leukocytosis and thrombocytosis, pseudohyperkalemia may exist in the absence of electrocardiogram changes or other clinical manifestations of true hyperkalemia thus leading to reevaluation of potassium values in serum, plasma and whole blood to arrive at the true picture. 相似文献
22.
Information and communication technologies (ICTs) and farmers’ decision-making across the agricultural supply chain 总被引：1，自引：0，他引：1
Jabir AliAuthor Vitae Sushil KumarAuthor Vitae 《International Journal of Information Management》2011,31(2):149-159
Using a case study of the Indian Tobacco Company's (ITC) e-Choupal initiative, the paper empirically analyses the role of information delivery through information and communication technology (ICT) in enhancing decision-making capabilities of Indian farmers. Users of e-Choupal show significantly better decision-making aptitudes, as compared to non-users, on various agricultural practices across the agricultural supply chain. Further, socio-demographic background's of the users such as education levels, the social category they belong to, income level's, and landholding size also play a significant role in impacting decision-making aptitudes. The impact is particularly prominent in production planning and post-harvest and marketing related decisions. Policy implications of these findings are discussed. The study emphasizes the importance of designing ICT enabled information systems to suit the socio-demographic profile of the user groups. 相似文献
23.
Rathore SS Agarwal SK Pande S Singh SK Mittal T Mittal B 《Indian journal of clinical biochemistry : IJCB》2011,26(3):222-229
Coumarinic oral-anticoagulants (COAs) are commonly used for treatment of thromboembolic events. However, these medications
have a narrow therapeutic range and there are large inter-individual variations in drug response. This is especially important
in the initial phases of oral-anticoagulant therapy. Recent advancements in pharmacogenetics have established that clinical
outcomes in oral-anticoagulant therapy are affected by genetic factors. The allelic variants of genes like cytochrome P450
2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) are closely associated with maintenance dose of oral
anti-coagulants. In addition, GGCX (Gamma-glutamyl carboxylase) polymorphism at position 12970 (rs11676382), CYP4F2 (rs2108622;
V433M; 1347 C > T) and Apolipoprotein E (APOE) variants have been shown to explain a small but significant influence on dose
requirements. There are large differences in the frequencies of these polymorphisms between different world populations which
are also related to the requirements of oral anticoagulants. However, the final drug dosage in an individual is determined
by complex sets of genetic and environmental factors and several dosing algorithms which combine clinical and genetic parameters
to predict therapeutic COA doses have also been developed. The algorithm based dose prediction shows the importance of pharmacogenetic
testing in patients undergoing oral anticoagulant therapies. 相似文献
24.
Bharosay A Saxena K Varma M Bharosay VV Pandey A 《Indian journal of clinical biochemistry : IJCB》2011,26(3):279-282
Stroke being the third leading cause of death and foremost cause of disability, if potential diagnostic utility of blood borne
protein biomarkers in predicting acute stroke is established, it would be a substantial adjunct to computerized tomography
and magnetic resonance imaging which have their own limitations. This study was done to correlate serum Interleukin 6, high
sensitivity C reactive protein at the time of admission with neurological worsening assessed by NIHSS at the time of admission
and 7 days after admission. 46 Patients admitted in neurology department SAIMS, Indore with first ever ischemic stroke within
72 h of onset were included in the study. All patients with history of stroke of more than 72 h onset, Infection & peripartum
stroke were excluded from the study. Disability scoring was done by NIHSS and their serum samples assayed for hsCRP, IL6 by
commercially available quantitative sandwich enzyme-linked immunoadsorbent assay kits. Serum samples of 50 control cases which
included healthy volunteers and staff from SAIMS were also analyzed for hsCRP, IL6 for comparative study. A significant correlation
was observed between NIHSS scoring and serum hsCRP and IL6 at the time of admission. Patients with initial high serum IL6
and hsCRP also showed significant clinical deterioration as assessed by NIHSS scoring 7 days after admission. Elevated hsCRP
and IL6 within 72 h of admission strongly correlated with functional disability in study population in India and may serve
as useful adjunct to CT Scan in emergency setting. 相似文献
25.
S. Pandey A. Sharma S. Dahia V. Shah V. Sharma R. M. Mishra Sw. Pandey R. Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(2):191-195
Blood biochemistry has significant effect on pathophysiology of human body. Recently few studies found the association of biochemical abnormalities in sickle cell patients. Sickle cell disease showed clinical variability where African ancestors have severe phenotype than Indian sicklers. Our aim was to evaluate the biochemicals in sickle cell patients and their effect on severity. Here we present the comparative biochemical levels in sickle cell patients as well as controls. Sickle cell patients diagnosed by HPLC and biochemical analysis done by Beckman-auto analyzer. T test applied for statistical analysis. Result showed the renal abnormality lesser in patients and related biochemical within the normal range and statistically not significant. Electrolytes, hepatic enzymes, alkaline phosphatase and glucose were elevated and statistically significant (P value <0.05). Observation of the study concludes the biochemical abnormality play a significant role in sickle cell patient’s physiopathology and can be used to management of the disease. 相似文献
26.
S. K. Pandey S. Pandey R. M. Mishra M. Indurkar 《Indian journal of clinical biochemistry : IJCB》2017,32(1):103-105
Normal iron levels are required to prevent thrombocytosis by inhibiting thrombopoiesis. Thrombocytosis is usually associated with a mild iron deficiency and is the result of a lack of inhibition of thrombopoiesis. Study participants were 430 iron deficiency anemia (IDA) patients. Ten (10) mL of venous blood were collected for the subjects. Ferritin analysis was done by ELISA method while Hemogram analysis was done by auto-analyzer. Factor V Leiden, PRTG20210A, and MTHFR C677T genotype analysis was performed by PCR–RFLP method. Among the patients, 9 were heterozygous (G>A) and 2 were homozygous (A>A) carrier of FV Leiden; while 20 were heterozygous (C>T) and 3 were homozygous (T>T) for MTHFR polymorphism. None of the patient was identified with PT mutation. Patients with thrombosis gene marker had lower hemoglobin, mean corpuscular volume, mean corpuscular haemoglobin levels, and mean corpuscular hemoglobin concentration than patients without thrombosis gene marker. Serum ferritin was elevated in subject with the absence of thrombosis gene markers. Our data suggest a high impact of inherited hypercoagulability risk factors in the pathogenesis of IDA and its complications. 相似文献
27.
K. K. Mishra H. P. Pandey R. H. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):26-28
Present study, involved two groups of chronic stress disorders, e.g. bronchial asthma and rheumatoid arthritis. Clinical investigations were launched on the blood samples of human subjects in which the levels of plasma cortisol, blood glucose, total plasma protein and serum cholesterol were assayed in diseased and normal control subjects. Observations in-vitro exhibited a notable change in the levels of all the biochemical parameters in patients of chronic disorders with respect to those of normal controls. The biochemical changes in asthmatics were comparatively more pronounced than those of rheumatoid arthritis patients. It reveals that bronchial asthma is an acute and early onset disorder because with chronicity of stressful events, there is a decline in stress response since hypothalamo-pituitary-adrenal (HPA) axis is not so competent to undergo major remodelling of its circuitry necessary for homeostatic maintanence. 相似文献
28.
Harbans Lai Rajesh Pandey S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2000,15(1):158-168
The past two decades have witnessed new facets in vitamin D metabolism. Free vitamin D3 till now considered to be limited to animal sources, has been shown to occur in plants. Further, the extrarenal synthesis of active vitamin D3 or calcitriol has been documented in physiological as well as in certain pathological conditions. At the cellular level, calcitriol acts through a dual mechanism. The genomic pathway involves the vitamin D receptor (VDR) which is of ubiquitous distribution and linked with various diseases. Besides, a nongenomic VDR—independent pathway also exists. The biological effects of calcitriol can no longer be dismissed by merely referring to calcium/bone homeostasis. It enhances the perinatal growth and suppresses the abnormal growth, as well. The effects on the endocrine, immune, cardiovascular, reproductive and nervous systems have also been characterized. It is compelling to believe that calcitriol and/or its analogues will find extensive applications at least in the treatment of osteoporosis, perinatal growth retardation, neoplasia, psoriasis, insulin resistance and transplantation. 相似文献
29.
The discovery of new drugs is often propelled by the increasing resistance of parasites to existing drugs and the availability of better technology platforms. The area of microfluidics has provided devices for faster screening of compounds, controlled sampling/sorting of whole animals, and automated behavioral pattern recognition. In most microfluidic devices, drug effects on small animals (e.g., Caenorhabditis elegans) are quantified by an end-point, dose response curve representing a single parameter (such as worm velocity or stroke frequency). Here, we present a multi-parameter extraction method to characterize modes of paralysis in C. elegans over an extended time period. A microfluidic device with real-time imaging is used to expose C. elegans to four anthelmintic drugs (i.e., pyrantel, levamisole, tribendimidine, and methyridine). We quantified worm behavior with parameters such as curls per second, types of paralyzation, mode frequency, and number/duration of active/immobilization periods. Each drug was chosen at EC75 where 75% of the worm population is responsive to the drug. At equipotent concentrations, we observed differences in the manner with which worms paralyzed in drug environments. Our study highlights the need for assaying drug effects on small animal models with multiple parameters quantified at regular time points over an extended period to adequately capture the resistance and adaptability in chemical environments. 相似文献
30.
Phenotypic Heterogeneity of Asian Indian Inversion Deletions Gγ(Aγδβ)0 Breakpoint A and Breakpoint B
Sanjay Pandey Sweta Pandey Ravi Ranjan Rahasyamani Mishra Monica Sharma Renu Saxena 《Indian journal of clinical biochemistry : IJCB》2013,28(1):98-101
Asian Indian inversion deletion Gγ (Aγδβ)0-thalassemia is a rare entities characterized by high HbF. Due to interaction with various genetic factors, patients with Gγ (Aγδβ)0-thalassemia showed clinical variability. Here we are presenting the phenotypic expression of Gγ(Aγδβ)0 thalassemia under influence of various co-inherited factors. Patient with α-globin gene deletion had mild phenotype than the patient with β-globin mutations. Patient with alpha gene deletion were presenting clinical character like thalassemia intermedia while Gγ (Aγδβ)0-thalassemia patients with co- presence of beta thalssemia mutation clinically behaved like thalassemia major. 相似文献