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31.
S. Pandey R. M. Mishra A. Suhail S. Rahul K. Ravi Sw. Pandey T. Seth R. Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(3):270-273
Usually sickle cell traits are asymptomatic but co-existence of various factrors may alter the clinical as well as biochemical levels. In India sickle cell traits are neglected condition. Here we are presenting the alpha deletion in association with low serum iron and increased HbF level with Xmn-1 carriers in sickle cell traits. Sickle traits with alpha deletions had significantly low level of serum iron (P-value <0.05) with low level of reticulocytes and red cell indices while Xmn-1 polymorphism associated with increased HbF level. Study concludes low serum iron associated with alpha deletions and high level of HbF associated with Xmn-1 polymorphism in sickle cell traits. 相似文献
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Tapasyapreeti Mukhopadhyay Arulselvi Subramanian Shivam Pandey Nirupam Madaan Anjan Trikha Rajesh Malhotra 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(2)
IntroductionThe COVID-19 pandemic has posed several challenges to clinical laboratories across the globe. Amidst the outbreak, errors occurring in the preanalytical phase of sample collection, transport and processing, can further lead to undesirable clinical consequences. Thus, this study was designed with the following objectives: (i) to determine and compare the blood specimen rejection rate of a clinical laboratory and (ii) to characterise and compare the types of preanalytical errors between the pre-pandemic and the pandemic phases.Materials and methodsThis retrospective study was carried out in a trauma-care hospital, presently converted to COVID-19 care centre. Data was collected from (i) pre-pandemic phase: 1st October 2019 to 23rd March 2020 and (ii) pandemic phase: 24th March to 31st October 2020. Blood specimen rejection rate was calculated as the proportion of blood collection tubes with preanalytical errors out of the total number received, expressed as percentage.ResultsTotal of 107,716 blood specimens were screened of which 43,396 (40.3%) were received during the pandemic. The blood specimen rejection rate during the pandemic was significantly higher than the pre-pandemic phase (3.0% versus 1.1%; P < 0.001). Clotted samples were the commonest source of preanalytical errors in both phases. There was a significant increase in the improperly labelled samples (P < 0.001) and samples with insufficient volume (P < 0.001), whereas, a significant decline in samples with inadequate sample-anticoagulant ratio and haemolysed samples (P < 0.001).ConclusionIn the ongoing pandemic, preanalytical errors and resultant blood specimen rejection rate in the clinical laboratory have significantly increased due to changed logistics. The study highlights the need for corrective steps at various levels to reduce preanalytical errors in order to optimise patient care and resource utilisation. 相似文献
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Phenotypic Heterogeneity of Asian Indian Inversion Deletions Gγ(Aγδβ)0 Breakpoint A and Breakpoint B
Sanjay Pandey Sweta Pandey Ravi Ranjan Rahasyamani Mishra Monica Sharma Renu Saxena 《Indian journal of clinical biochemistry : IJCB》2013,28(1):98-101
Asian Indian inversion deletion Gγ (Aγδβ)0-thalassemia is a rare entities characterized by high HbF. Due to interaction with various genetic factors, patients with Gγ (Aγδβ)0-thalassemia showed clinical variability. Here we are presenting the phenotypic expression of Gγ(Aγδβ)0 thalassemia under influence of various co-inherited factors. Patient with α-globin gene deletion had mild phenotype than the patient with β-globin mutations. Patient with alpha gene deletion were presenting clinical character like thalassemia intermedia while Gγ (Aγδβ)0-thalassemia patients with co- presence of beta thalssemia mutation clinically behaved like thalassemia major. 相似文献
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The discovery of new drugs is often propelled by the increasing resistance of parasites to existing drugs and the availability of better technology platforms. The area of microfluidics has provided devices for faster screening of compounds, controlled sampling/sorting of whole animals, and automated behavioral pattern recognition. In most microfluidic devices, drug effects on small animals (e.g., Caenorhabditis elegans) are quantified by an end-point, dose response curve representing a single parameter (such as worm velocity or stroke frequency). Here, we present a multi-parameter extraction method to characterize modes of paralysis in C. elegans over an extended time period. A microfluidic device with real-time imaging is used to expose C. elegans to four anthelmintic drugs (i.e., pyrantel, levamisole, tribendimidine, and methyridine). We quantified worm behavior with parameters such as curls per second, types of paralyzation, mode frequency, and number/duration of active/immobilization periods. Each drug was chosen at EC75 where 75% of the worm population is responsive to the drug. At equipotent concentrations, we observed differences in the manner with which worms paralyzed in drug environments. Our study highlights the need for assaying drug effects on small animal models with multiple parameters quantified at regular time points over an extended period to adequately capture the resistance and adaptability in chemical environments. 相似文献
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Gaurav Pandey Zhaochun Ren Shuaiqiang Wang Jari Veijalainen Maarten de Rijke 《Information Retrieval》2018,21(6):481-506
We address the feature extraction problem for document ranking in information retrieval. We then propose LifeRank, a Linear feature extraction algorithm for Ranking. In LifeRank, we regard each document collection for ranking as a matrix, referred to as the original matrix. We try to optimize a transformation matrix, so that a new matrix (dataset) can be generated as the product of the original matrix and a transformation matrix. The transformation matrix projects high-dimensional document vectors into lower dimensions. Theoretically, there could be very large transformation matrices, each leading to a new generated matrix. In LifeRank, we produce a transformation matrix so that the generated new matrix can match the learning to rank problem. Extensive experiments on benchmark datasets show the performance gains of LifeRank in comparison with state-of-the-art feature selection algorithms. 相似文献
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Rama Devi Mittal Amita Pandey Balraj Mittal Kailash Nath Agarwal 《Indian journal of clinical biochemistry : IJCB》2003,18(1):111-116
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet
(18–20 mg/kg) did not significantly change the gross body, weight and tissue weights of brain and liver. Packed cell volume
(PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly
(p<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain
decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (p<0.001) in synaptic vesicular membranes from iron-deficient
rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding
was reduced by 63% in the vesicular membranes of iron deficient animals. These studies indicate that iron plays important
functional role in both excitatory and inhibitory neurotransmitter receptors. 相似文献
38.
Naturalistic Language Recordings Reveal “Hypervocal” Infants at High Familial Risk for Autism 
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下载免费PDF全文 Meghan R. Swanson Mark D. Shen Jason J. Wolff Brian Boyd Mark Clements James Rehg Jed T. Elison Sarah Paterson Julia Parish‐Morris J. Chad Chappell Heather C. Hazlett Robert W. Emerson Kelly Botteron Juhi Pandey Robert T. Schultz Stephen R. Dager Lonnie Zwaigenbaum Annette M. Estes Joseph Piven the IBIS Network 《Child development》2018,89(2):e60-e73
Children's early language environments are related to later development. Little is known about this association in siblings of children with autism spectrum disorder (ASD), who often experience language delays or have ASD. Fifty‐nine 9‐month‐old infants at high or low familial risk for ASD contributed full‐day in‐home language recordings. High‐risk infants produced more vocalizations than low‐risk peers; conversational turns and adult words did not differ by group. Vocalization differences were driven by a subgroup of “hypervocal” infants. Despite more vocalizations overall, these infants engaged in less social babbling during a standardized clinic assessment, and they experienced fewer conversational turns relative to their rate of vocalizations. Two ways in which these individual and environmental differences may relate to subsequent development are discussed. 相似文献
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Rama Devi Mittal Amita Pandey Balraj Mittal Kailash Nath Agarwal 《Indian journal of clinical biochemistry : IJCB》2002,17(2):1-6
Eight weeks of latent iron deficiency in weaned female rats of Sprague Dawley strain maintained on experimental low-iron diet
(18–20 mg/Kg) did not significantly change the gross body weight and tissue weights of brain and liver. Packed cell volume
(PCV) and hemoglobin concentration remained unaltered. However, non-heme iron content in liver and brain decreased significantly
(P<0.001). The activities of glutamate dehydrogenase, glutamic acid decarboxylase, and GABA-transaminase (GABA-T) in brain
decreased by 15%, 11.4% and 25.7% respectively. However, this decrease was not statistically significant. Binding of3H Muscimol at pH 7.5 and 1 mg protein/assay increased by 143% (P<0.001) in synaptic vesicular membranes from iron-deficient
rats as compared to the controls.3H glutamate binding to the synaptic vesicles was also carried out under similar condition. However, the L-glutamate binding
was reduced by 63% in the vesicular membranes of iron deficient animals. These studies in dicate that iron plays an important
functional role in both excitatory and inhibitory neurotransmitter receptors. 相似文献
40.
V. K. Verma V. Ramesh Satyendra Tewari R. K. Gupta Nakul Sinha C. M. Pandey 《Indian journal of clinical biochemistry : IJCB》2005,20(2):68-74
A study has been carried out on 250 CAD patients to see how the serum levels of three antioxidants i.e., Vitamin C, Bilirubin
and Ceruloplasmin are related to the CAD risk factors and characteristics in these patients. The number of severe category
CAD patients declined by 7–18% with increasing serum levels of the three antioxidants and, triple vessel disease declined
by 14–20%. A decline of 39% in Myocardial Infarction (MI) occurred with increasing serum Ceruloplasmin. Serum Ceruloplasmin
was significantly lower in the MI group compared to the non MI group CAD patients. There was a steady and a significant decline
in the mean values of serum levels of cholesterol, Triglyceride, VLDL cholesterol along with BMI with increasing serum level.
The study indicates that with increasing serum levels of the three antioxidants studied, the % MI along with % Triple vessel
disease and severity of CAD goes down suggesting that the modifiable risk factors have to be suitably modified in order to
maintain a reasonably high level of these antioxidants, as the risk factors are inversely related to the serum antioxidant
levels. 相似文献