A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats     

He XL  Yin HL  Wu J  Zhang K  Liu Y  Yuan T  Rao HL  Li L  Yang G  Zhang XM 《Journal of Zhejiang University. Science. B》2011,12(1):32-39

Radiation therapy has been widely applied in cancer treatment. However, it often causes thrombocytopenia (deficiency of white blood cells) as an adverse effect. Recombinant human interleukin-6 (rhIL-6) has been found to be a very effective way against this thrombocytopenia, but IL-6 has low stability in blood, which reduces its efficacy. To increases the stability and half-life of rhIL-6, it was modified by polyethylene glycol (PEG). The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled with ¹²⁵I were examined after subcutaneous injection in rats. The pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics, and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption, t _{1/2K a}) and 19.77–21.53 h (elimination, t _1/2Ke), and peak concentrations at 20.51–21.96 h (t _peak) in rats. Half-lives and t _peak of PEG-rhIL-6 were longer than those of rhIL-6 previously reported. In the present study, for deposition of PEG-rhIL-6 in rats, the tissue distribution examination showed that blood was the major organ involved, rather than liver. However, as to the elimination of PEG-rhIL-6, the major organ was the kidney. The excretion fraction of the injection dose recovered from urine was 23.32% at 192 h after subcutaneous administration. Less than 6% of PEG-rhIL-6 was eliminated via the feces at 192 h. These results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer.  相似文献   

Nuclear magnetic resonance     

B. D. Nageswara Rao 《Resonance》2015,20(11):969-985

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Role of MRI in medical diagnostics     

Rashmi Rao  Ramesh Venkatesan  Sairam Geethanath 《Resonance》2015,20(11):1003-1011

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Education policy borrowing and mediation across and within countries     

Yusuf Sayed  Paul Morris  Nitya Rao 《Compare》2015,45(6):836-839

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Privacy risk quantification in education data using Markov model     

Dinusha Vatsalan  Thierry Rakotoarivelo  Raghav Bhaskar  Paul Tyler  Djazia Ladjal 《British journal of educational technology : journal of the Council for Educational Technology》2022,53(4):804-821

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Socioscientific Issues Thinking and Action in the Midst of Science-in-the-Making     

Herman  Benjamin C.  Clough  Michael P.  Rao  Asha 《Science & Education》2022,31(5):1105-1139

Science & Education - Like all SSI, the COVID-19 pandemic requires decisions that are contentious, involve scientific thinking, and vary across social groups. This investigation determined how...  相似文献   

The Integration of Prelaboratory Assignments within Neuroanatomy Augment Academic Performance,Increase Engagement,and Enhance Intrinsic Motivation in Students     

Venugopala Rao Bhagavathula  Viswakanth Bhagavathula  Rohan S. Moinis  Joydeep Dutta Chaudhuri 《Anatomical sciences education》2022,15(3):576-586

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少数民族流动人口子女思想政治教育问题的原因及对策探析     

饶丽红  吕成云 《科教文汇》2014,(20):15-16

加强流动人口中少数民族的思想政治教育,对于构建社会主义和谐社会具有重要而深远的意义。当前流动人口中少数民族子女思想政治教育工作存在很多问题,究其原因主要有宗教思想的根深蒂固、家庭和学校教育的影响等。如何加强少数民族流动人口子女的思想政治教育问题,需要国家、学校、社会以及家庭共同的努力。  相似文献   

Science education for empowerment and social change: A case study of a teacher educator in urban Pakistan     

Rubina Zahur  Angela Calabrese Barton  Bhaskar Raj Upadhyay 《International Journal of Science Education》2013,35(9):899-917

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Education policy reforms: problems and prospects     

Yusuf Sayed  Nitya Rao  Paul Morris 《Compare》2012,42(1):1-4

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