排序方式： 共有21条查询结果，搜索用时 15 毫秒
11.
12.
The incidence of cardiovascular and cerebrovascular disease is steadily increasing in South East Asian countries including
Indian sub continent. Many lipids, apolipoproteins and Lp (a) except HDL-C and apo A-I, A-II are implicated as risk factors
for coronary artery disease and cerebrovascular disease. There is great need to have national guidelines for each country
like the ATP III guidelines recommended for U.S. population. For recommending appropriate medical decision limits, it is mandatory
that each country establishes reference intervals pertaining to their population due to dietary, genetic and environmental
diversity. In the present study, reference intervals for serum lipids, apolipoproteins and Lp (a) were established in a total
of 1923 healthy Indian reference individuals comprising 1161 healthy men and 762 healthy women from Andhra Pradesh. For each
analyte viz., serum total cholesterol, HDL-C, LDL-C, triglycerides, Lp (a), Apo A-I, Apo A-II, B, C-II, C-III and E, mean,
two SD, median, confidence limits of mean, different percentile values are presented. The study also includes decade wise
changes in each analyte and comparison of lipids, lipoproteins and Lp (a) among few populations covering U.S., India, Japan,
Sweden, Finland and China. Reference Intervals for all lipid and lipoprotein parameters will immensely help in assessing associated
risk for cardiovascular and cerebrovascular diseases in India. Additionally, the results will be beneficial in formulating
our own guidelines pertaining to Indian population. 相似文献
13.
The present study deals with the evaluation and comparison of the tumor markers for prostatic carcinoma—The Total Acid Phosphatase
(ACP Total) and its Prostatic Fraction (ACP PF) estimated by the enzyme kinetic method, an immunoreactive Prostatic Acid Phosphatase
(PAP) and Prostate Specific Antigen (PSA) estimated by enzyme immunoassay. The comparison of all four markers revealed that
there was no perfect positive correlation between any of these four markers. PSA had shown a better correlation with ACP Total
and its prostatic fraction ACP PF. No correlation was observed between PSA and PAP. Of the four markers PAP exhibited a very
low sensitivity, positive and negative predictive values. PSA had shown an absolute specificity, sensitivity, positive and
negative predictive values for adenocarcinoma prostate. PSA levels in all phases of disease showed a 100% correlation with
disease status. Being a marker with very high tissue specificity and sensitivity, it is revolutionizing the diagnosis of prostatic
carcinoma. Hence, it could be used effectively for screening of elderly people over 50 years of age who are at high risk for
developing prostatic carcinoma for early diagnosis of this disease. 相似文献
14.
Pradeep Naik S. Indira R. M. Pitchappan T. Malati 《Indian journal of clinical biochemistry : IJCB》1991,6(2):119-123
Antibodies against human leucocyte antigens (HLA) in sera from uni and multiparous women are the potential source of HLA reagent.
The present study was undertaken to screen 169 sera from pregnant women for the presence of HLA antibodies employing 26 panel
cells (Peripheral blood lymphocytes) having known HLA phenotypes. 20.7% (35/169) sera were found to be positive for HLA class-1
antibodies. Present study generated one monospecific, (r=0.6 for A32) the duospecific sera (r=0.5 for A2 B35, r=0.47 A1 DR6
and r=0.7 A28 B51), and rest multispecific sera (r=below 0.4). These positive sera will be utilized as HLA reagents in future
studies for tissue typing. 相似文献
15.
T. Malati 《Indian journal of clinical biochemistry : IJCB》2009,24(2):111-122
Reference Intervals denote normative values related to laboratory parameters/analytes used by diagnostic centers for clinical
diagnosis. International guidelines recommend that every country must establish reference intervals for healthy individuals
belonging to a group of homogeneous population. Considering enormous racial and ethnic diversity of Indian population, it
is mandatory to establish reference intervals specific to Indian population. The overview on reference interval describes
why the national organizations in India need to initiate nationwide efforts to establish its own laboratory standards for
apparently healthy reference individuals belonging to our polygenetic, polyethnic, polyracial, multilinguistic and multicultural
predominantly rural and appreciable urban Indian population with varied dietary habits. 相似文献
16.
R. Dhananjayan K. S. Srivani Koundinya T. Malati Vijay Kumar Kutala 《Indian journal of clinical biochemistry : IJCB》2016,31(4):372-379
Endothelial dysfunction is an imbalance in the production of vasodilator factors and when this balance is disrupted, it predisposes the vasculature towards pro-thrombotic and pro-atherogenic effects. This results in vasoconstriction, leukocyte adherence, platelet activation, mitogenesis, pro-oxidation, impaired coagulation and nitric oxide production, vascular inflammation, atherosclerosis and thrombosis. Endothelial dysfunction is focussed as it is a potential contributor to the pathogenesis of vascular disease in diabetes mellitus. Under physiological conditions, there is a balanced release of endothelial-derived relaxing and contracting factors, but this delicate balance is altered in diabetes mellitus and atherosclerosis, thereby contributing to further progression of vascular and end-organ damage. This review focuses on endothelial dysfunction in atherosclerosis, insulin resistance, metabolic syndrome, oxidative stress associated with diabetes mellitus, markers and genetics that are implicated in endothelial dysfunction. 相似文献
17.
T. Malati B. Yadagiri D. Murali Mohan Krishna V. Shantaram D. Raghunadharao K. Subbarao 《Indian journal of clinical biochemistry : IJCB》2001,16(1):52-59
In the present study, monoclonal gammapathy was identified in a total of 245 patients of plasma cell dyscrasias during period
of 1987 to 2000. The monoclonal band was identified in serum by agar gel electrophoresis in all the cases and in urine in
a few cases. Characterization of paraprotein (monoclonal immunoglobulin class and light chain type) was carried out by employing
immunoelectrophoresis and/or immunofixation electrophoresis using heavy chain specific gamma, alpha, mu, delta and epsilon
and light chain specific kappa (K), lambda (λ) antisera. Serum immunoglobulins Ig G, Ig A, and Ig M were estimated by immunoturbidometry.
Serum urea, creatinine, uric acid, alkaline phosphatase, total proteins, albumin, calcium and phosphorus were estimated by
using routine biochemical methods. Among the 245 cases, 73.1% monoclonal gammapathies were of secretory type and 7.3% were
non-secretory. Monoclonal gammapathies were associated with 80.4% of multiple myeloma, 8.9% of solitary plasmacytoma, 4.1%
of extra-medullary plasmacytoma, 3.3% of lymphoma and 2.9% of plasma cell leukemia. Classification of secretory monoclonal
immunoglobulin revealed monoclonal immunoglobulin Ig G in 74%, Ig A 15% and Ig M in 2.9% cases. 相似文献
18.
In this study tumor markers CA 125, CEA and CA 19-9 were evaluated to assess the best tumor marker for epithelial ovarian carcinomas in diagnosis, prognosis and management. The results indicated that CA 125 is the best and the most superior marker today for the epithelial ovarian malignancies irrespective of the histologic type. CA 125 has the highest positivity rate in mucinous tumors compared to CEA and CA 19-9. Combined assay of either CEA or CA 19-9 or both along with CA 125 did not increase diagnostic sensitivity compared to sensitivity achieved by CA 125 alone for epithelial tumors of the ovary. Serum CA 125 concentration correlated well with pretherapy, stable course and recurrence of ovarian carcinoma. CA 125 could be used effectively for diagnosis, prognosis and monitoring of the ovarian malignancies as evident from long term follow up of adenocarcinoma ovary. 相似文献
19.
Tangirala Malati Ph. D. D. Murali Mohan Krishna B. Sadasivudu 《Indian journal of clinical biochemistry : IJCB》1991,6(1):51-57
Serum fructosamine (SFRC) was estimated using single colour reading procedure in 50 normals and 160 adult onset random diabetics.
Serum fructosamine levels were observed to be 1.86±0.321 m moles/L (Range 1.0 to 2.4) and 3.44±0.671 (Range 2.0 to 5.7) in
normal and diabetic subjects respectively. Serum fructosamine levels as determined by the method adapted, were found to be
unaffected by a transient rise in serum glucose levels during an oral glucose tolerance test. Significantly elevated SFRC
concentration was also seen in diabetic groups in spite of different combinations of antidiabetic treatment. Attempts to correlate
SFRC with duration and secondary complications of diabetes did show significant elevation in all the groups irrespective of
duration and complications thus indicating poor glycemic control. 相似文献
20.
The present preliminary study was performed to find out stability of total prostate specific antigen (PSA) and free prostate
specific antigen (FPSA) in serum of healthy males as well as in patients of benign and malignant disorders of prostate at
various freezing and nonfreezing temperatures and at different duration of time.
The results of our study indicated long-term stability of both the analytes in frozen serum. Serum total and free PSA were
stable only for three to four days in regular refrigerators in unfrozen states. Clotted blood kept at room temperature (25°C–30°C)
did not cause change in concentrations of both the analytes for twenty four hours. 相似文献