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11.
Andrea Teija Kuna Milena Hanek Ines Vukasovi Nora Nikolac Gabaj Valentina Vidranski Ivana elap Marijana Miler Nevenka Stan
in Brankica imac Marcela
ivkovi Marko
arak Marta Kmet Marijana Jovanovi Sanja Tadinac Sandra upraha Goreta Josipa Peria Ivan amija Mario tefanovi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(1)
IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests have been suggested as an additional diagnostic tool in highly suspected cases with a negative molecular test and determination of seroprevalence in population. We compared the diagnostic performance of eight commercial serological assays for IgA, IgM, and IgG antibodies to the SARS-CoV-2 virus.Materials and methodsThe comparison study was performed on a total of 76 serum samples: 30 SARS-CoV-2 polymerase chain reaction (PCR)-negative and 46 SARS-CoV-2 PCR-positive patients with asymptomatic to severe disease and symptoms duration from 3-30 days. The study included: three rapid lateral flow immunochromatographic assays (LFIC), two enzyme-linked immunosorbent assays (ELISA), and three chemiluminescence immunoassays (CLIA).ResultsAgreement between IgM assays were minimal to moderate (kappa 0.26 to 0.63) and for IgG moderate to excellent (kappa 0.72 to 0.92). Sensitivities improved with > 10 days of symptoms and were: 30% to 89% for IgM; 89% to 100% for IgG; 96% for IgA; 100% for IgA/IgM combination; 96% for total antibodies. Overall specificities were: 90% to 100% for IgM; 85% to 100% for IgG; 90% for IgA; 70% for IgA/IgM combination; 100% for total antibodies. Diagnostic accuracy for IgG ELISA and CIA assays were excellent (AUC ≥ 0.90), without significant difference. IgA showed significantly better diagnostic accuracy than IgM (P < 0.001).ConclusionThere is high variability between IgM assays independently of the assay format, while IgG assays showed moderate to perfect agreement. The appropriate time for testing is crucial for the proper immunity investigation. 相似文献
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This article examines the problem of specification error in 2 models for categorical latent variables; the latent class model and the latent Markov model. Specification error in the latent class model focuses on the impact of incorrectly specifying the number of latent classes of the categorical latent variable on measures of model adequacy as well as sample reallocation to latent classes. The results show that the clarity of remaining latent classes, as measured by the entropy statistic depends on the number of observations in the omitted latent class—but this statistic is not reliable. Specification error in the latent Markov model focuses on the transition probabilities when a longitudinal Guttman process is incorrectly specified. The findings show that specifying a longitudinal Guttman process that is not true in the population impacts other transition probabilities through the covariance matrix of the logit parameters used to calculate those probabilities. 相似文献
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Tihomir Asparouhov 《Structural equation modeling》2013,20(4):495-508
This article presents a new method for multiple-group confirmatory factor analysis (CFA), referred to as the alignment method. The alignment method can be used to estimate group-specific factor means and variances without requiring exact measurement invariance. A strength of the method is the ability to conveniently estimate models for many groups. The method is a valuable alternative to the currently used multiple-group CFA methods for studying measurement invariance that require multiple manual model adjustments guided by modification indexes. Multiple-group CFA is not practical with many groups due to poor model fit of the scalar model and too many large modification indexes. In contrast, the alignment method is based on the configural model and essentially automates and greatly simplifies measurement invariance analysis. The method also provides a detailed account of parameter invariance for every model parameter in every group. 相似文献