Co‐Curation and the Public History of Science and Technology     

Tim Boon 《Curator: The Museum Journal》2011,54(4):383-387

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Do R&D subsidies affect SMEs’ access to external financing?     

Miguel Meuleman  Wouter De Maeseneire 《Research Policy》2012,41(3):580-591

Many countries spend sizeable sums of public money on R&D grants to alleviate debt and equity gaps for small firms’ innovation projects. In making such awards, knowledgeable government officials may certify firms to private financiers. Using a unique Belgian dataset of 1107 approved requests and a control group of denied requests for a specific type of R&D grant, we examine the impact of subsidies on small firms’ access to external equity, short term and long term debt financing. We find that obtaining an R&D subsidy provides a positive signal about SME quality and results in better access to long-term debt.  相似文献   

GearSketch: an adaptive drawing-based learning environment for the gears domain     

Frank A. J. Leenaars  Wouter R. van Joolingen  Hannie Gijlers  Lars Bollen 《Educational technology research and development : ETR & D》2014,62(5):555-570

GearSketch is a learning environment for the gears domain, aimed at students in the final years of primary school. It is designed for use with a touchscreen device and is based on ideas from drawing-based learning and research on cognitive tutors. At the heart of GearSketch is a domain model that is used to transform learners’ strokes into gears and chains, animate the turning of the gears and check whether learners’ solutions to practice problems satisfy the given constraints. Additionally, this domain model is the basis for GearSketch’s learner model and item generation an selection mechanisms. The learner model is used to track learners’ knowledge and adaptively select items as they progress through the practice problems. Two experimental evaluation studies show that GearSketch’s interface and animations lead to improved learning outcomes, but that its adaptive features do not significantly affect posttest results.  相似文献   

Rapid microfluidic solid-phase extraction system for hyper-methylated DNA enrichment and epigenetic analysis     

Arpita De  Wouter Sparreboom  Albert van den Berg  Edwin T. Carlen 《Biomicrofluidics》2014,8(5)

Genetic sequence and hyper-methylation profile information from the promoter regions of tumor suppressor genes are important for cancer disease investigation. Since hyper-methylated DNA (hm-DNA) is typically present in ultra-low concentrations in biological samples, such as stool, urine, and saliva, sample enrichment and amplification is typically required before detection. We present a rapid microfluidic solid phase extraction (μSPE) system for the capture and elution of low concentrations of hm-DNA (≤1 ng ml⁻¹), based on a protein-DNA capture surface, into small volumes using a passive microfluidic lab-on-a-chip platform. All assay steps have been qualitatively characterized using a real-time surface plasmon resonance (SPR) biosensor, and quantitatively characterized using fluorescence spectroscopy. The hm-DNA capture/elution process requires less than 5 min with an efficiency of 71% using a 25 μl elution volume and 92% efficiency using a 100 μl elution volume.  相似文献   

Stakeholder interaction within research consortia on emerging technologies: Learning how and what?     

Anneloes Roelofsen  Wouter P.C. BoonRoy R. Kloet  Jacqueline E.W. Broerse 《Research Policy》2011,40(3):341-354

One of the challenges for public-private R&D collaborations in emerging scientific fields is to actively include the demand side. Insight in how to facilitate learning between stakeholders is, however, lacking. In this paper we present an approach to facilitate and analyse learning processes in multi-stakeholder interactions within public-private research consortia working on new science and technologies. The learning processes that took place during dialogue meetings within the framework of the Dutch Ecogenomics Consortium were analysed, including a reflection on the actual effects. The results show that a carefully structured dialogue method facilitates learning between researchers, users and policy-related participants, and that this learning to some extent is anchored within the Ecogenomics Consortium. At the same time, the results point to the challenges of translating learning into action.  相似文献   

Book reviews     

Joel H. Wiener  Pamela K. Gilbert  J. James Mancuso  Gustavo Verdesio  J. Kendrick Noble  David A. Kronick  Thomas L. Boon  John Tebbel  Sally P. Bennett  J. James Mancuso  Gretchen V. Douglas  Richard W. Clement  Nat Bodian 《Publishing Research Quarterly》1996,12(2):64-86

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Exploring vocational and academic fields of study: development and validation of the Flemish SIMON Interest Inventory (SIMON-I)     

Lot Fonteyne  Bart Wille  Wouter Duyck  Filip De Fruyt 《International Journal for Educational and Vocational Guidance》2017,17(2):233-262

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Structural and physiological changes of the human body upon SARS-CoV-2 infection     

Wu  Zhonglin  Zhang  Qi  Ye  Guo  Zhang  Hui  Heng  Boon Chin  Fei  Yang  Zhao  Bing  Zhou  Jing 《Journal of Zhejiang University. Science. B》2021,22(4):310-317

Since December 2019, the novel coronavirus(severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)) has spread to many countries around the world, developing into a global pandemic with increasing numbers of deaths reported worldwide. To data, although some vaccines have been developed, there are no ideal drugs to treat novel coronavirus pneumonia(coronavirus disease 2019(COVID-19)). By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide, this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2. We observed that the most prominent pathological changes in COVID-19 patients are diffuse alveolar damage(DAD) of the lungs and microthrombus formation,resulting in an imbalance of the ventilation/perfusion ratio and respiratory failure. Although direct evidence of viral infection can also be found in other organs and tissues, the viral load is relatively small. The conclusion that the injuries of the extrapulmonary organs are directly caused by the virus needs further investigation.  相似文献   

Does Aristotle believe that habituation is only for children?     

Wouter Sanderse 《Journal of moral education》2020,49(1):98-110

ABSTRACT

Full virtue and practical wisdom comprise the end of neo-Aristotelian moral development, but wisdom cannot be cultivated straight away through arguments and teaching. Wisdom is integrated with, and builds upon, habituation: the acquisition of virtuous character traits through the repeated practice of corresponding virtuous actions. Habit formation equips people with a taste for, and commitment to, the good life; furthermore it provides one with discriminatory and reflective capacities to know how to act in particular circumstances. Unfortunately, habituation is often understood primarily as a method suitable only for children. This article examines whether Aristotle limited habituation to children and, if not, what the relationship between habituation and wisdom beyond childhood might look like. This article concludes that wisdom-guided habituation is also possible for adults who continue and confirm their already established virtuous habits. The implications of this for professional moral education are subsequently discussed.  相似文献   

Short-term memory for order but not for item information is impaired in developmental dyslexia     

Wibke M. Hachmann  Louisa Bogaerts  Arnaud Szmalec  Evy Woumans  Wouter Duyck  Remo Job 《Annals of dyslexia》2014,64(2):121-136

Recent findings suggest that people with dyslexia experience difficulties with the learning of serial order information during the transition from short- to long-term memory (Szmalec et al. Journal of Experimental Psychology: Learning, Memory, & Cognition 37(5): 1270-1279, 2011). At the same time, models of short-term memory increasingly incorporate a distinction of order and item processing (Majerus et al. Cognition 107: 395-419, 2008). The current study is aimed to investigate whether serial order processing deficiencies in dyslexia can be traced back to a selective impairment of short-term memory for serial order and whether this impairment also affects processing beyond the verbal domain. A sample of 26 adults with dyslexia and a group of age and IQ-matched controls participated in a 2?×?2?×?2 experiment in which we assessed short-term recognition performance for order and item information, using both verbal and nonverbal material. Our findings indicate that, irrespective of the type of material, participants with dyslexia recalled the individual items with the same accuracy as the matched control group, whereas the ability to recognize the serial order in which those items were presented appeared to be affected in the dyslexia group. We conclude that dyslexia is characterized by a selective impairment of short-term memory for serial order, but not for item information, and discuss the integration of these findings into current theoretical views on dyslexia and its associated dysfunctions.  相似文献