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11.
Bishnubrata Patra Yu-Sheng Peng Chien-Chung Peng Wei-Hao Liao Yu-An Chen Keng-Hui Lin Yi-Chung Tung Chau-Hwang Lee 《Biomicrofluidics》2014,8(5)
We developed a microfluidic device to culture cellular spheroids of controlled sizes and suitable for live cell imaging by selective plane illumination microscopy (SPIM). We cocultured human umbilical vein endothelial cells (HUVECs) within the spheroids formed by hepatocellular carcinoma cells, and studied the distributions of the HUVECs over time. We observed that the migration of HUVECs depended on the size of spheroids. In the spheroids of ∼200 μm diameters, HUVECs migrated outwards to the edges within 48 h; while in the spheroids of ∼250 μm diameters, there was no outward migration of the HUVECs up to 72 h. In addition, we studied the effects of pro-angiogenic factors, namely, vascular endothelial growth factor (VEGF) and fibroblast growth factor (β-FGF), on the migration of HUVECs in the carcinoma cell spheroid. The outward migration of HUVECs in 200 μm spheroids was hindered by the treatment with VEGF and β-FGF. Moreover, some of the HUVECs formed hollow lumen within 72 h under VEGF and β-FGF treatment. The combination of SPIM and microfluidic devices gives high resolution in both spatial and temporal domains. The observation of HUVECs in spheroids provides us insight on tumor vascularization, an ideal disease model for drug screening and fundamental studies. 相似文献
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Haiyan Hua Peichi Tung 《高教发展与评估》2002,(3):5-11
本刊特约美国哈佛大学教育研究生院高级研究员花海燕博士及其研究生撰写介绍哈佛的系列学术文章。这组文章以哈佛教研院为入切点 ,鸟瞰哈佛教育的方方面面。这无疑对我国加入WTO后 ,高校将如何应对教育国际化的形势大有裨益。您读完这组系列的开篇之作 ,有何感想、建议和要求 ,请函告编辑部 相似文献
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This paper extends the concept of a reproducing kernel resolution space to a Banach space setting. The resultant reproducing kernel resolution space, however, remains a Hilbert space thereby permitting a number of problems in mathematical system theory to be transformed from Banach space to Hilbert space. Particular emphasis is given to the study of Banach space valued random variables and the scattering operator formalism for an electric network. 相似文献
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踏莎行 送殿兒赴英倫
絕崤分携,危樓獨佇.萋萋草綠王孫去.
老來别易見應難,臨歧忍作傷心語.病掩孤檠,夢回疏杵.千山萬水愁風雨.東西南北總天涯,離魂隨汝知何處!
這是香港詞人番禺劉景堂(1887-1963)一九六○年所作,時年七十四歲. 相似文献
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Yin Cheong Cheng Mo Ching Magdalena Mok Kwok Tung Tsui 《Educational Research for Policy and Practice》2002,1(1-2):7-21
When Hong Kong is moving towards a knowledge society in the new millennium, research is clearly necessary to provide a knowledge
base for educational development and reform to meet the challenges of globalization and high technology in the world. This
report aims to review the education policy environment in Hong Kong and see whether research can be encouraged to support
policy development and practice improvement. Particularly, the report will give a brief introduction to the recent initiatives
in Hong Kong school education since the establishment of the Special Administrative Region in 1997 and discusses the potential
research agenda to support the ongoing education reforms at the school system.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Tung‐hsien He 《Journal of Research in Reading》2008,31(2):224-242
This study explored the effects of achievement goals on English as a foreign language (EFL) college students' reading strategy use and reading comprehension from the perspective of multiple goals. Fifty‐seven participants verbalised their thoughts while reading an English expository essay. They also completed assessments on their reading goal profiles and reading proficiency. The results of stimulated recall indicated that participants with profiles characterised by strong mastery and strong performance goals used intra‐sentential, inter‐paragraph, intra‐paragraph and monitoring/evaluating strategies significantly more frequently than did their counterparts. In contrast, participants with profiles characterised by strong mastery but weak performance goals utilised these strategies more often than those participants with weak mastery but strong performance goals. The strong‐mastery–strong‐performance goal profile served as a significant, positive predictor for degrees of reading comprehension. In line with these findings, suggestions for EFL reading pedagogy are provided. 相似文献
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人体动态稳定性理论及防跌倒扰动性训练进展 总被引：1，自引：0，他引：1
随着世界范围内老龄化社会问题的日益严重,以及一些有运动障碍的特殊群体的扩大,致使跌倒成为了一个严重的社会问题。人体动态稳定性理论是防跌倒研究的理论基础,目前已经取得了有价值的进展。人体动态稳定性理论不同于静态稳定性理论,后者给出的是人体质心位置与支撑面之间的相对位置关系,而前者增加了人体质心速度的因素,给出的是人体质心位置—速度状态与动态稳定区域之间的关系,可利用稳度来判定人体所处的稳定状态,甚至定量评价人体的动态稳定程度。影响跌倒的主要因素有二:稳度为负和支撑不力。在防跌倒的研究中进行适应性练习可显著地提高滑前稳度和滑后稳度,分别体现了前馈控制和反馈控制对人体动态稳定性的神经生理影响。 相似文献
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Siva Sankaran Kris Sankaran Tung Bui 《Decision Sciences Journal of Innovative Education》2023,21(2):68-82
Applying Herzberg's motivation-hygiene theory, we studied the determinants of student satisfaction in using R in a Decision Support Systems course that previously used Excel to teach Data Mining and Business Analytics (DMBA). The course is a degree requirement, and prior programming experience is not a prerequisite. We hypothesized that motivators for student satisfaction with R would include: (i) an intrinsic interest in DMBA, (ii) a perception that R is a better tool than Excel for DMBA, and (iii) a favorable view of R as a facilitator of career advancement. We postulated that the hygiene factor was the compulsory course requirement to learn R, a new and challenging language to students in this study. Data from 120 students, analyzed using Principal Component Analysis (PCA) and Generalized Additive Modeling (GAM), showed that motivators were positively related to satisfaction while hygiene factors were neutral. Students showed willingness to take on a harder challenge in exchange for intrinsic and future career benefits. The model can be useful in curriculum design or career advisement to increase student satisfaction in learning new software skills while meeting market demands. 相似文献
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