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991.
Farrokhi E Shayesteh F Asadi Mobarakeh S Roghani Dehkordi F Ghatreh Samani K Hashemzadeh Chaleshtori M 《Indian journal of clinical biochemistry : IJCB》2011,26(3):244-248
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations
in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH
has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran.
The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related
Iranian possible FH subjects were studied. Diagnosis of FH was based on the Dutch Lipid Clinic Network diagnostic criteria.
All samples were initially tested for three common APOB gene mutations including R3500Q, R3500 W and R3531C using PCR-RFLP
assay. Subsequently, promoter and coding region of the LDLR gene was screened by PCR-SSCP analysis and positive results were
confirmed by DNA sequencing. Four previously reported polymorphisms 1413G > A, 1725C > T, 1773T > C and 2140 + 5G > A were
found in ~17% (5/30) of population studied. Moreover, no variation was found in APOB gene. Our data indicated that LDLR and
APOB gene mutations have not contribution to possible FH in Iranian population studied here. However, we examined three common
APOB mutations and LDLR in only 30 patients, and to determine the role of these genes in developing FH in Iran, more FH samples
and populations needed to be investigated for the mutations of the related genes. 相似文献
992.
Dash P Pati S Mangaraj M Sahu PK Mohapatra PC 《Indian journal of clinical biochemistry : IJCB》2011,26(2):182-186
Now a days measurement of molecular forms of PSA has gained importance in clinical practice. Several studies have demonstrated
the production of PSA in female tissues, such as breast. The present piece of work has been undertaken with an objective to
estimate the relative proportion of the molecular forms of PSA in serum along with serum testosterone in benign and malignant
breast tumor cases and to analyze their association with the severity of the disease process 34 malignant and 26 benign breast
disease cases along with 33 healthy controls of same age group were enrolled in this study for evaluation. Serum testosterone
was measured by ELISA, whereas serum total PSA (TPSA) and free PSA (FPSA) were estimated by electrochemiluminescence immunoassay.
A significant rise of fasting plasma glucose along with prominent dyslipidemia was observed in breast tumor cases. Marked
rise in serum testosterone as well as TPSA and FPSA was documented in both benign and malignant breast tumor cases. Serum
testosterone revealed a significant positive association with both TPSA and FPSA pointing towards an etiological association
between them. However, surgical removal of tumor mass resulted in a marked decline of presurgical value of both TPSA and FPSA
with a non-significant fall in serum testosterone revealing tumor tissue as the source of FPSA and TPSA. Thus, estimation
of PSA provides prognostic information that may assist in future treatment. 相似文献
993.
994.
Gupta S Verma M Gupta AK Kaur A Kaur V Singh K 《Indian journal of clinical biochemistry : IJCB》2011,26(2):178-181
Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines
recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism
and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and
the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples
(87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently
as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests.
77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7%
in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction
and order the appropriate test in a rational and cost effective manner. 相似文献
995.
996.
997.
我小时候,家住在村头。我很喜欢睡在房顶上,在这里什么都可以听得见,还可以看得很远。村子左边是一片光秃秃的荒沙地;右边和后面都是果园;正面是一条很深的山沟,山沟里奔流着—道溪水。
一天,天还不亮流水声就把我唤醒了。我望着外面,忽然发现山沟那边有什么东西闪了一下。 相似文献
998.
贯彻落实科学发展观的首要任务是保护环境与资源,实现经济社会发展和生态建设、资源节约、环境保护的统一,因而与构建循环经济模式之间具有密切的协同关系。主要分析和探讨了科学发展观视野下的循环经济模式构建方法。 相似文献
999.
抓好高校辅导员队伍建设对加强和改进大学生思想政治教育工作具有重要的现实意义。当前高校辅导员队伍普遍存在配备欠合理、非专业化程度高、思想不稳定等问题,为改变这一现状,提高辅导员的综合素质和能力,高校应不断完善辅导员队伍建设、完善辅导员绩效考评及考核机制、重视对辅导员的培训等。 相似文献
1000.
概述德国电子图书市场的现状,重点论述德国电子阅读设备的传播和电子图书的市场容量。指出电子图书和电子阅读器市场的最重要驱动力和市场壁垒,并对2015年的电子图书和阅读器市场状况进行预测。 相似文献